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      Primary adenocarcinoma of the seminal vesicle

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          Abstract

          Primary adenocarcinoma of the seminal vesicle is a rare condition with only about 60 cases described in the literature. The unusual characteristics of this disease makes diagnosis difficult and treatment strategies differ as there are no specific guidelines available. This report presents a case of adenocarcinoma of the seminal vesicle with lung metastases in which surgical and chemotherapeutic treatments have been carried out. The MVAC dose dense regimen following local resection seems effective in this scenario and may be used in the treatment of this disease.

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          Primary adenocarcinoma of the seminal vesicles.

          Ralf Thiel, Peter Effert (2002)
          We provide an overview of seminal vesicle carcinoma, a rare entity that is difficult to diagnose and traditionally has been associated with a poor prognosis. A literature search for seminal vesicle carcinoma was performed, and current concepts related to the diagnosis and clinical management were reviewed. Two unpublished additional cases recently treated at our institution were added to the international experience. Special attention was given to new developments in diagnostic methods. Histopathological changes and biomarker criteria are provided to allow accurate diagnosis of this condition. Early diagnosis of seminal vesicle carcinoma has often been difficult due to a lack of immunohistochemical markers that distinguish this entity from invasive adenocarcinoma of adjacent organs. A total of 49 documented cases of seminal vesicle carcinoma in men between 19 and 90 years old has been reported in the current literature. Two additional cases that were diagnosed and treated at our institution are incorporated into this review. Recently the tissue marker CA 125 has substantially increased the accurate diagnosis of seminal vesicle carcinoma. In addition, increased serum CA 125 in patients with this disease has been reported and serum levels correlate well with the clinical course of the disease. Radical surgery in combination with adjuvant radiotherapy or androgen deprivation has resulted in long-term palliation in some patients with advanced disease. Including seminal vesicle carcinoma in the differential diagnosis of lower urinary tract symptoms will improve detection. Improved imaging tools and the availability of a serum marker will undoubtedly enhance detection at the earliest stages. More defined histopathological criteria will allow diagnosis even with small biopsy specimens. Radical surgery appears to offer the best chance for cure but hormonal manipulation and radiotherapy seem to be effective as adjuvant treatment modalities.
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            DNA methylation of GSTP1 as biomarker in diagnosis of prostate cancer.

            Gully A. P. C. Burns, Marianne T Hopkins, Michael N Routledge (2006)
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              Carcinoma of the seminal vesicle.

              R C Benson, W Clark, G Farrow (1984)
              Strict criteria were applied to 12 cases of carcinoma of the seminal vesicle in the Mayo Clinic tumor registry. Diagnosis was carcinoma of the seminal vesicle if the neoplasm was a papillary or anaplastic carcinoma localized primarily to the seminal vesicle and no other primary tumors were demonstrated. In addition, some degree of mucin production was required, especially when prostatic involvement was present. Only 2 of our cases and 35 cases reported previously were judged acceptable or probable cases of carcinoma of the seminal vesicle. Prognosis for patients with this tumor is poor. A combination of extirpative surgery and hormonal therapy appears to provide the best opportunity for extended survival, although this remains to be proved.
              Article 0 comments Cited 12 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Rare Tumors
                Journal ID (publisher-id): RT
                Title: Rare Tumors
                Publisher: PAGEPress Publications, Pavia, Italy
                ISSN (Print): 2036-3605
                ISSN (Electronic): 2036-3613
                Publication date (Electronic): 03 October 2017
                Publication date Collection: 03 October 2017
                Volume: 9
                Issue: 3
                Electronic Location Identifier: 7074
                Affiliations
                [1 ] Department of Medical Oncology, Hôpital Saint-Louis, APHP, Paris, France
                [2 ] Paris Diderot University , Sorbonne Paris Cité, Paris, France
                [3 ] Servicio de Oncologia Clinica. Hospital de Clinicas, Montevideo, Uruguay
                [4 ] Department of Anatomic-Pathology, Hopital Saint-Louis, APHP, Paris, France
                [5 ] Department of Urology, Hôpital Saint-Louis, APHP, Paris, France
                Author notes
                Correspondence: Safae Terrisse, Hôpital Saint Louis, Service d’Oncologie Médicale 1, Claude Vellefaux 75010 Paris, France. +33.142.49.42.47 - +33.142.49.98.95. safae.terrisse@ 123456gmail.com

                Contributions: the authors contributed equally.

                Conflict of interest: the authors declare no potential conflict of interest.

                Article
                DOI: 10.4081/rt.2017.7074
                PMC ID: 5643883
                PubMed ID: 29081928
                SO-VID: dfb42ca6-630e-418a-a9da-a0eb7ed6e6ae
                Copyright © ©Copyright S. Terrisse et al., 2017
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 31 January 2017
                Date revision received : 17 August 2017
                Date accepted : 17 August 2017
                Page count
                Figures: 0, Tables: 1, Equations: 0, References: 11, Pages: 2
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: carcinoma,seminal vesicle,chemotherapy,lung metastasis,remission
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: carcinoma, seminal vesicle, chemotherapy, lung metastasis, remission

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