AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Blocking of the autophagy-signaling has the potential to improve cancer therapy. In the present study, the role of autophagy for radioresistance of human tumor cells was tested under clinically relevant hypoxia (1% O2).

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Radiother Oncol

Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Publisher: Elsevier BV

ISSN (Electronic): 1879-0887

ISSN (Print): 0167-8140

Publication date (Electronic): Sep 2015

Volume: 116

Issue: 3

Affiliations

[1 ] Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany; Department of Radiation Oncology, Technische Universität München (TUM), and HMGU CCG - Innate Immunity in Tumor Biology, Germany; Section of Radiation Oncology, Vetsuisse Faculty, University of Zürich, Switzerland.

[2 ] Department of Dermatology, University of Tuebingen, Germany.

[3 ] Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany.

[4 ] Department of Radiation Oncology, Technische Universität München (TUM), and HMGU CCG - Innate Immunity in Tumor Biology, Germany.

[5 ] Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany. Electronic address: hans-peter.rodemann@uni-tuebingen.de.

Article

Publisher Item ID: S0167-8140(15)00437-5

DOI: 10.1016/j.radonc.2015.08.012

PubMed ID: 26318663

SO-VID: e17a1185-667b-413c-828c-445d58b19639

History

Keywords: Autophagy,Clinical relevant hypoxia,Ionizing radiation,Solid tumor cells

Data availability:

Keywords: Autophagy, Clinical relevant hypoxia, Ionizing radiation, Solid tumor cells

AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.

Read this article at

Abstract

Related collections

Universal stem cells

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 56

Cited by 14