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      Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on fluid distribution: A comparison study with furosemide and tolvaptan.

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          Abstract

          Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic properties. We recently reported that an SGLT2 inhibitor ameliorated extracellular fluid expansion with a transient increase in urinary Na+ excretion. However, the effects of SGLT2 inhibitors on fluid distribution in comparison to conventional diuretics remain unclear.

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          Author and article information

          Journal
          Nephrology (Carlton)
          Nephrology (Carlton, Vic.)
          Wiley
          1440-1797
          1320-5358
          Dec 22 2018
          Affiliations
          [1 ] Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
          [2 ] Department of Surgery, Nasu Minami Hospital, Tochigi, Japan.
          [3 ] Department of Internal Medicine, Nasu Minami Hospital, Tochigi, Japan.
          Article
          10.1111/nep.13552
          30578654
          e2e9a24f-e941-4ffb-bf6d-f6ccf466f34c
          History

          bioimpedance analysis,SGLT2 inhibition,fluid distribution,natriuresis,osmotic diuretic

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