DBS of Thalamic Centromedian Nucleus for Lennox–Gastaut Syndrome ( ESTEL Trial)

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Abstract

Prior uncontrolled studies have reported seizure reductions following deep brain stimulation (DBS) in patients with Lennox-Gastaut syndrome (LGS), but evidence from randomized controlled studies is lacking. We aimed to formally assess the efficacy and safety of DBS to the centromedian thalamic nucleus (CM) for the treatment of LGS.

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Contributors

Linda J. Dalic: (View ORCID Profile)

Journal

Title: Annals of Neurology

Abbreviated Title: Annals of Neurology

Publisher: Wiley

ISSN (Print): 0364-5134

ISSN (Electronic): 1531-8249

Publication date Created: February 2022

Publication date (Electronic): December 28 2021

Publication date (Print): February 2022

Volume: 91

Issue: 2

Pages: 253-267

Affiliations

[1 ]Department of Medicine (Austin Health) University of Melbourne Heidelberg VIC Australia

[2 ]Department of Neurology Austin Health Heidelberg VIC Australia

[3 ]The Florey Institute of Neuroscience and Mental Health Heidelberg VIC Australia

[4 ]Murdoch Children's Research Institute Parkville VIC Australia

[5 ]Bionics Institute East Melbourne VIC Australia

[6 ]Department of Neurosurgery Austin Health Heidelberg VIC Australia

[7 ]Department of Surgery University of Melbourne Parkville VIC Australia

[8 ]Department of Medicine University of Melbourne, and Department of Neurology, The Royal Melbourne Hospital Parkville VIC Australia

Article

DOI: 10.1002/ana.26280

PubMed ID: 34877694

SO-VID: e3c039a0-38e0-4ac4-b43b-1e3a72be3a1a

License:

http://creativecommons.org/licenses/by-nc-nd/4.0/

http://doi.wiley.com/10.1002/tdm_license_1.1

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