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      Audit of physical health monitoring in children and adolescents receiving antipsychotics in neurodevelopmental clinics in Northumberland

      research-article
      ,
      World Journal of Psychiatry
      Baishideng Publishing Group Inc
      Antipsychotic, Children, Physical health, Guidelines

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          Abstract

          AIM

          To ascertain performance against the standards set by National Institute for Clinical Excellence (NICE) guidelines on physical health monitoring of thirty children and adolescents prescribed antipsychotics in neurodevelopmental clinics in Northumberland and identifying areas for improvement in practice.

          METHODS

          The audit involved a review of recorded documentation pertaining to physical health monitoring in patient electronic records pertaining to children and adolescents attending neurodevelopmental clinics in Northumberland prescribed antipsychotics. Clients were also contacted by telephone if relevant documentation could not be identified or retrieved to confirm the details. 32 case notes were perused of which 2 were excluded as they had refused to have venepuncture which was documented in the electronic records.

          RESULTS

          The overall audit results demonstrated partial compliance with NICE guidelines on physical health monitoring in children and adolescents prescribed antipsychotics. Bi-annual recording of height, weight, blood pressure, pulse rate and review of side effects was completed in 100% of subjects. However, annual monitoring for blood tests including liver function, renal function full blood count as well as biannual monitoring of serum prolactin, serum lipid profile was completed only in 56% of subjects. Comparative baseline characteristics between the two groups (compliant and non-compliant with guidelines) found no differences based on any socio-demographic or clinical variables. However, the proportion of patients in the group compliant to guidelines was higher in the age group of 12-17 years as compared to < 12 years (70.58% vs 38.46%), though not statistically significant (χ 2 = 1.236; P = 0.24).

          CONCLUSION

          Development of tailored and specific guidelines for physical health monitoring in children and adolescents prescribed antipsychotics taking into consideration clinical effectiveness and safety profile is likely to improve adherence rates.

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          Most cited references17

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          Treatment recommendations for the use of antipsychotics for aggressive youth (TRAAY). Part II.

          To develop treatment recommendations for the use of antipsychotic medications for children and adolescents with serious psychiatric disorders and externalizing behavior problems. Using a combination of evidence- and consensus-based methodologies, recommendations were developed in six phases as informed by three primary sources of information: (1) current scientific evidence (published and unpublished), (2) the expressed needs for treatment-relevant information and guidance specified by clinicians in a series of focus groups, and (3) consensus of clinical and research experts derived from a formal survey and a consensus workshop. Fourteen treatment recommendations on the use of atypical antipsychotics for aggression in youth with comorbid psychiatric conditions were developed. Each recommendation corresponds to one of the phases of care (evaluation, treatment, stabilization, and maintenance) and includes a brief clinical rationale that draws upon the available scientific evidence and consensus expert opinion derived from survey data and a consensus workshop. Until additional research from controlled trials becomes available, these evidence- and consensus-based treatment recommendations may be a useful approach to guide the use of antipsychotics in youth with aggression.
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            Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study.

            To evaluate weight gain associated with olanzapine, risperidone, and haloperidol treatment and its clinical risk factors in adolescent patients. The study was conducted at three adolescent psychiatric departments in two mental health centers in the Tel Aviv area. All patients were Jewish Israelis. Weight and body mass index (BMI) of hospitalized adolescents treated with olanzapine (n = 21), risperidone (n = 21), or haloperidol (n = 8) were prospectively monitored on a weekly basis for the first 12 weeks of treatment. Various clinical risk factors were tested for association with weight gain. The olanzapine and risperidone groups experienced significant weight gain between baseline and endpoint (p 7%) was recorded in 19 patients (90.5%), 9 patients (42.9%), and 1 (12.5%) patient, respectively Gender (males), low concern about gaining weight (females), low baseline BMI, and paternal BMI were positively correlated with weight gain, whereas previous neuroleptic history, neuroleptic dosage, response to treatment, and illness duration were not. Olanzapine and risperidone are associated with extreme weight gain in adolescents, much higher than that reported in adults. This side effect should be taken into consideration before prescribing these medications, especially in patients at high risk.
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              • Article: not found

              Cognitive effects of risperidone in children with autism and irritable behavior.

              The objective of this research was to explore the effects of risperidone on cognitive processes in children with autism and irritable behavior. Thirty-eight children, ages 5-17 years with autism and severe behavioral disturbance, were randomly assigned to risperidone (0.5 to 3.5 mg/day) or placebo for 8 weeks. This sample of 38 was a subset of 101 subjects who participated in the clinical trial; 63 were unable to perform the cognitive tasks. A double-blind placebo-controlled parallel groups design was used. Dependent measures included tests of sustained attention, verbal learning, hand-eye coordination, and spatial memory assessed before, during, and after the 8-week treatment. Changes in performance were compared by repeated measures ANOVA. Twenty-nine boys and 9 girls with autism and severe behavioral disturbance and a mental age >or=18 months completed the cognitive part of the study. No decline in performance occurred with risperidone. Performance on a cancellation task (number of correct detections) and a verbal learning task (word recognition) was better on risperidone than on placebo (without correction for multiplicity). Equivocal improvement also occurred on a spatial memory task. There were no significant differences between treatment conditions on the Purdue Pegboard (hand-eye coordination) task or the Analog Classroom Task (timed math test). Risperidone given to children with autism at doses up to 3.5 mg for up to 8 weeks appears to have no detrimental effect on cognitive performance.
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                Author and article information

                Contributors
                Journal
                World J Psychiatry
                WJP
                World Journal of Psychiatry
                Baishideng Publishing Group Inc
                2220-3206
                22 March 2018
                22 March 2018
                : 8
                : 1
                : 27-32
                Affiliations
                Child and Adolescent Mental Health Services, Tyne and Wear NHS Foundation Trust, Morpeth NE61 3BP, United Kingdom
                Child and Adolescent Mental Health Services, Tyne and Wear NHS Foundation Trust, Morpeth NE61 3BP, United Kingdom
                Author notes

                Author contributions: Gnanavel S collected data and prepared manuscript; Hussain S was the sponsor for the audit, contributed to designing the audit, did a quality check and proof read the manuscript.

                Correspondence to: Dr. Sundar Gnanavel, MD, Child and Adolescent Mental Health Services, Tyne and Wear NHS Foundation Trust, Villa No 9, Morpeth NE61 3BP, United Kingdom. sundar.gnanavel@ 123456ntw.nhs.uk

                Telephone: +44-73-41672503

                Article
                jWJP.v8.i1.pg27
                10.5498/wjp.v8.i1.27
                5862652
                29568729
                e47fe087-7a96-4c76-96b8-0c872746f112
                ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

                This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

                History
                : 26 October 2017
                : 29 December 2017
                : 16 January 2018
                Categories
                Clinical Practice Study

                antipsychotic,children,physical health,guidelines
                antipsychotic, children, physical health, guidelines

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