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      Management of severe crush injury in a front-line tent ICU after 2008 Wenchuan earthquake in China: an experience with 32 cases

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          Abstract

          Introduction

          The experience on management of crush injury after a devastating earthquake is lacking, and there are even less reports on the front-line critical care of these patients. A front-line intensive care unit (ICU) was set up in a tent after the disastrous Wenchuan earthquake (May, 12, 2008, China), where 32 patients suffering from crush injury were treated from May 12 to May 26. This study summarized our experience on management of 32 crush injury patients in a front-line tent ICU.

          Methods

          We retrospectively analyzed the clinical data of 32 crush injury patients treated in our frontline tent ICU. Using limited equipment, we observed the arterial blood gas parameters, blood routine, alanine aminotransferase, lactate dehydrogenase, creatine kinase, creatinine, blood urea nitrogen, and urine protein of patients. We also closely watched for changes in crush injury symptoms, urine output, and the dangerous complications of crush injury.

          Results

          Eighteen of the 32 patients developed traumatic shock, 9 had acute renal failure, 6 had acute heart failure, 2 had stress ulcers and 4 had multiple organ dysfunction syndrome (MODS). The symptoms of 17 patients met the criteria of crush syndrome; hemodialysis and prompt surgical intervention were given to them when necessary. Prompt treatment in our tent ICU improved the symptoms of patients to different degrees. The limb distension and sensory dysfunction were improved and the urine output was increased or even restored to the normal level in some patients. Serological parameters were improved in most patients after admission. Five (15.63%) patients underwent amputation due to severe infection in our group. Six (18.75%) patients died, 4 due to MODS and 2 due to acute renal failure.

          Conclusions

          Severe crushing injuries and life-threatening complications are major causes of death after major disasters like earthquakes. Prompt treatment and close monitoring of the severe complications are of great importance in saving patients' lives. Establishment of a well-equipped front-line ICU close to the epicentre of the earthquake allows for prompt on the spot rescue of critical patients with crush injury, greatly decreasing the mortality rate and complications and avoiding amputation. There should be sufficient equipment to meet the needs of more patients.

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          Most cited references37

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          Prognostic value of extravascular lung water in critically ill patients.

          Measurement of extravascular lung water (EVLW) as a clinical tool for the assessment of pulmonary function has been found to be more appropriate than oxygenation parameters or radiographic techniques. In this study, we analyzed the prognostic value of EVLW in critically ill patients. Retrospective analysis. Operative ICU of a university hospital. We retrospectively analyzed 373 critically ill patients (133 female and 240 male patients; age range, 10 to 89 years; mean +/- SD age, 53 +/- 19 years) who were treated in our ICU between 1996 and 2000. All these patients were hemodynamically monitored by the transpulmonary double-indicator (thermo-dye) dilution technique. Each patient received a femoral artery sheath through which a 4F flexible catheter with an integrated thermistor and fiberoptic was advanced into the infradiaphragmatic aorta. EVLW was calculated using a computer system. For each measurement, 15 to 17 mL of cooled 2% indocyanine green were injected central venously. In our results, maximum EVLW was significantly higher in nonsurvivors (n = 186) than in survivors (n = 187) [median, 14.3 mL/kg vs 10.2 mL/kg, respectively; p < 0.001]. In univariate logistic regression models, EVLW (r(2) = 0.024, p = 0.003) at baseline as well as simplified acute physiology score (SAPS) II (r(2) = 0.135, p < 0.0001) and APACHE (acute physiology and chronic health evaluation) II scores (r(2) = 0.050, p < 0.0001) were significant predictors of mortality. If SAPS II and APACHE II scores are combined, r(2) increases to 0.136, but the improvement over SAPS II alone is not significant. The addition of baseline EVLW further increases r(2) to 0.149 (p = 0.021 for the improvement), indicating that EVLW contributes independently to prognosis. EVLW correlated well with survival (ie, nonsurvivors had significantly higher EVLW values than survivors) and is an independent predictor of prognosis.
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            Management of crush-related injuries after disasters.

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              Accuracy of transpulmonary thermodilution versus gravimetric measurement of extravascular lung water.

              Pulmonary edema is a severe and often life-threatening condition. The diagnosis of pulmonary edema and its quantification have great clinical significance and yet can be difficult. A new technique based on thermodilution measurement using a single indicator has recently been developed (PiCCO, Pulsion Medical Systems, AG Germany). This method allows the measurement of extravascular lung water and thus can quantify degree of pulmonary edema. The technique has not been compared with a gold standard, gravimetric measurement of extravascular lung water. Therefore, the objective of this study was to determine the ability of extravascular lung water measurement with the PiCCO to reflect the extravascular lung water as measured with a gravimetric technique in a dog model of pulmonary edema. Prospective, randomized animal study. A university animal research laboratory. Fifteen mongrel dogs (n = 5/group) weighing 20-30 kg. The dogs were anesthetized and mechanically ventilated. Five dogs served as controls; in five dogs hydrostatic pulmonary edema was induced using inflation of a left atrial balloon combined with fluid administration to maintain a high pulmonary artery occlusion pressure; and in five dogs pulmonary edema was induced by intravenous injection of oleic acid. After a period of stabilization in a state of pulmonary edema, extravascular lung water was measured with the PiCCO monitor. The animals were then killed, and extravascular lung water was measured using a gravimetric technique. There was a very close (r =.967, p <.001) relationship between transpulmonary thermodilution and gravimetric measurements. The measurement with the PiCCO was consistently higher, by 3.01 +/- 1.34 mL/kg, than the gravimetric measurement. Measurement of extravascular lung water using transpulmonary thermodilution with a single indicator is very closely correlated with gravimetric measurement of lung water in both increased permeability and hydrostatic pulmonary edema.
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                Author and article information

                Journal
                Crit Care
                Crit Care
                Critical Care
                BioMed Central
                1364-8535
                1466-609X
                2009
                6 November 2009
                : 13
                : 6
                : R178
                Affiliations
                [1 ]Emergency Department, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China
                [2 ]Intensive Care Unit, The People's Hospital of Jiangyou, No. 346 middle Jinlun Road, Jiangyou City, Sichuan Province, 621700, China
                Article
                cc8160
                10.1186/cc8160
                2811944
                19895693
                e4837b03-44c1-443d-9696-74305c963fb1
                Copyright ©2009 Li et al.; licensee BioMed Central Ltd.

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 22 March 2009
                : 6 May 2009
                : 4 October 2009
                : 6 November 2009
                Categories
                Research

                Emergency medicine & Trauma
                Emergency medicine & Trauma

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