Pyrrolo-dC and pyrrolo-C: fluorescent analogs of cytidine and 2′-deoxycytidine for the study of oligonucleotides

Berry, David A.; Jung, Kee-Yong; Wise, Dean S.; Pearson, William H.; Somers, Robert L.; Randolph, John B.; Mackie, Hugh; Sercel, Anthony D

doi:10.1016/j.tetlet.2004.01.108

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Pyrrolo-dC and pyrrolo-C: fluorescent analogs of cytidine and 2′-deoxycytidine for the study of oligonucleotides

Author(s): David A. Berry , Kee-Yong Jung , Dean S. Wise , Anthony D. Sercel , William H. Pearson , Hugh Mackie , John B. Randolph , Robert L. Somers

Publication date Created: March 2004

Publication date (Print): March 2004

Journal: Tetrahedron Letters

Publisher: Elsevier BV

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A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara (1975)

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Replacing the nucleobases in DNA with designer molecules.

Eric T. Kool (2002)

DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.