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Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study.
Scott D Corley
1 ,
Andrew E Epstein ,
John P DiMarco ,
Michael J Domanski ,
Nancy Geller ,
H Leon Greene ,
Richard A Josephson ,
Joyce C Kellen ,
Richard C Klein ,
Andrew D Krahn ,
Mary Mickel ,
L Brent Mitchell ,
Joy Dalquist Nelson ,
Yves Rosenberg ,
Eleanor Schron ,
Lynn Shemanski ,
Albert L Waldo ,
D George Wyse
Mar 30 2004
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Abstract
The AFFIRM Study showed that treatment of patients with atrial fibrillation and a high risk for stroke or death with a rhythm-control strategy offered no survival advantage over a rate-control strategy in an intention-to-treat analysis. This article reports an "on-treatment" analysis of the relationship of survival to cardiac rhythm and treatment as they changed over time.