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      Association between renin-angiotensin system antagonist use and mortality in heart failure with severe renal insufficiency: a prospective propensity score-matched cohort study.

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          Abstract

          In heart failure (HF) with reduced ejection fraction (EF), renin-angiotensin receptor (RAS) antagonists reduce mortality. However, severe renal insufficiency was an exclusion criterion in trials. We tested the hypothesis that RAS antagonists are associated with reduced mortality also in HF with severe renal insufficiency.

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          Author and article information

          Journal
          Eur. Heart J.
          European heart journal
          Oxford University Press (OUP)
          1522-9645
          0195-668X
          Sep 07 2015
          : 36
          : 34
          Affiliations
          [1 ] Department of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.
          [2 ] Department of Clinical Science and Education, SöS, Karolinska Institutet, 11883 Stockholm, Sweden.
          [3 ] Division of Cardiovascular Medicine, Faculty of Health Sciences, Department of Medicine and Health Sciences, Department of Cardiology UHL, Linköping University, County Council of Östergötland, 58191 Linköping, Sweden.
          [4 ] Department of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden Department of Cardiology, N3:06, Karolinska University Hospital, 17176 Stockholm, Sweden lars.lund@alumni.duke.edu.
          Article
          ehv268
          10.1093/eurheartj/ehv268
          26069212

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