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[Genetic variants of the complement components and HLA-antigens associated in patients with psoriasis vulgaris in Japanese].

Author(s): Y Ishibashi, Hiroshi Nakagawa, K Tokunaga, K Matsuki, K Omoto, T Juji, G Dewald

Publication date: 1988-12-31

Journal: Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology

Keywords: Asian Continental Ancestry Group, Complement System Proteins, genetics, Female, HLA Antigens, Humans, Japan, Male, Polymorphism, Genetic, Psoriasis, Risk

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Abstract

Genetic polymorphisms of the serum complement components (C2, C4, C6, and C7) and HLA-antigens were studied in Japanese patients with psoriasis vulgaris. Among these complement components, positive associations with C4A4 and C4B2 were obtained. In addition to the previously reported haplotypes HLA-Cw6-B13 and Cw6-Bw57-DR7, the extended haplotype HLA-Cw11-Bw46-C4A4. 4B2-BFS-C2C-DRw8 may be a high risk haplotype in Japanese patients with psoriasis vulgaris.

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PubMed ID:: 2746964

ScienceOpen disciplines: Chemistry

Keywords: Asian Continental Ancestry Group,Complement System Proteins,genetics,Female,HLA Antigens,Humans,Japan,Male,Polymorphism, Genetic,Psoriasis,Risk

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ScienceOpen disciplines: Chemistry

Keywords: Asian Continental Ancestry Group, Complement System Proteins, genetics, Female, HLA Antigens, Humans, Japan, Male, Polymorphism, Genetic, Psoriasis, Risk

[Genetic variants of the complement components and HLA-antigens associated in patients with psoriasis vulgaris in Japanese].

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