Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) aptasensors combined with rolling circle amplification and bio-bar-coded AuNP enhancement have been applied to detect the human α-thrombin for the first time. The assay platform exhibited excellent selectivity and sensitivity with detection limit as low as 0.78 aM.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Chem. Commun. (Camb.)

Title: Chemical communications (Cambridge, England)

ISSN (Electronic): 1364-548X

ISSN (Print): 1359-7345

Publication date (Electronic): Feb 11 2014

Volume: 50

Issue: 12

Affiliations

[1 ] Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China.

Article

DOI: 10.1039/c3cc48223e

PubMed ID: 24365778

SO-VID: e8930486-4602-4ede-bb38-a539252f4e1f

History

Data availability:

Comments

Comment on this article

scite_

Cited by 17

See all cited by