The Consensus Hepatitis C Cascade of Care: Standardized Reporting to Monitor Progress Toward Elimination

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Cascade-of-care (CoC) monitoring is an important component of the response to the global hepatitis C virus (HCV) epidemic. CoC metrics can be used to communicate, in simple terms, the extent to which national and subnational governments are advancing on key targets, and CoC findings can inform strategic decision-making regarding how to maximize the progression of individuals with HCV to diagnosis, treatment, and cure. The value of reporting would be enhanced if a standardized approach were used for generating CoCs. We have described the Consensus HCV CoC that we developed to address this need and have presented findings from Denmark, Norway, and Sweden, where it was piloted. We encourage the uptake of the Consensus HCV CoC as a global instrument for facilitating clear and consistent reporting via the World Health Organization (WHO) viral hepatitis monitoring platform and for ensuring accurate monitoring of progress toward WHO's 2030 hepatitis C elimination targets.

Related collections

Most cited references 30

Record: found
Abstract: found
Article: found

Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

Sarah Blach, Stefan Zeuzem, Michael Manns … (2017)

The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update of-and expansion on-the 2014 analysis, which reported 80 million (95% CI 64-103) viraemic infections in 2013.

0 comments Cited 405 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Historical epidemiology of hepatitis C virus (HCV) in selected countries.

P Bruggmann, Mark T. Berg, A L H Øvrehus … (2014)

Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. For some countries, data from centralized registries were used to estimate diagnosis and treatment rates. Data for the number of liver transplants and the proportion attributable to HCV were obtained from centralized databases. Viremic prevalence estimates varied widely between countries, ranging from 0.3% in Austria, England and Germany to 8.5% in Egypt. The largest viremic populations were in Egypt, with 6,358,000 cases in 2008 and Brazil with 2,106,000 cases in 2007. The age distribution of cases differed between countries. In most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use. Diagnosis, treatment and transplant levels also differed considerably between countries. Reliable estimates characterizing HCV-infected populations are critical for addressing HCV-related morbidity and mortality. There is a need to quantify the burden of chronic HCV infection at the national level.

0 comments Cited 83 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

The Treatment Cascade for Chronic Hepatitis C Virus Infection in the United States: A Systematic Review and Meta-Analysis

Baligh Yehia, Asher J. Schranz, Craig A Umscheid … (2014)

Background Identifying gaps in care for people with chronic hepatitis C virus (HCV) infection is important to clinicians, public health officials, and federal agencies. The objective of this study was to systematically review the literature to provide estimates of the proportion of chronic HCV-infected persons in the United States (U.S.) completing each step along a proposed HCV treatment cascade: (1) infected with chronic HCV; (2) diagnosed and aware of their infection; (3) with access to outpatient care; (4) HCV RNA confirmed; (5) liver fibrosis staged by biopsy; (6) prescribed HCV treatment; and (7) achieved sustained virologic response (SVR). Methods We searched MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews for articles published between January 2003 and July 2013. Two reviewers independently identified articles addressing each step in the cascade. Studies were excluded if they focused on specific populations, did not present original data, involved only a single site, were conducted outside of the U.S., or only included data collected prior to 2000. Results 9,581 articles were identified, 117 were retrieved for full text review, and 10 were included. Overall, 3.5 million people were estimated to have chronic HCV in the U.S. Fifty percent (95% CI 43–57%) were diagnosed and aware of their infection, 43% (CI 40–47%) had access to outpatient care, 27% (CI 27–28%) had HCV RNA confirmed, 17% (CI 16–17%) underwent liver fibrosis staging, 16% (CI 15–16%) were prescribed treatment, and 9% (CI 9–10%) achieved SVR. Conclusions Continued efforts are needed to improve HCV care in the U.S. The proposed HCV treatment cascade provides a framework for evaluating the delivery of HCV care over time and within subgroups, and will be useful in monitoring the impact of new screening efforts and advances in antiviral therapy.

0 comments Cited 66 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Jeffrey V Lazarus: (View ORCID Profile)

Journal

Title: Clinical Infectious Diseases

Publisher: Oxford University Press (OUP)

ISSN (Print): 1058-4838

ISSN (Electronic): 1537-6591

Publication date Created: December 15 2019

Publication date Created: November 27 2019

Publication date Created: July 28 2019

Publication date Other: December 15 2019

Publication date (Print): November 27 2019

Publication date (Electronic): July 28 2019

Volume: 69

Issue: 12

Pages: 2218-2227

Affiliations

[1 ]Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain

[2 ]Center for Disease Analysis Foundation, Lafayette, Colorado, USA

[3 ]Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden

[4 ]Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

[5 ]Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark

[6 ]Department of Infectious Diseases, Imperial College London, London, United Kingdom

[7 ]Department of Infectious Diseases, Akershus University Hospital, Lørenskog, Norway

[8 ]Institute of Clinical Medicine, University of Oslo, Oslo, Norway

[9 ]Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom

[10 ]The Kirby Institute, UNSW Sydney, Sydney, Australia

[11 ]Department of Infectious Diseases, School of Medical Sciences, Örebro University, Örebro, Sweden

[12 ]Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Brumunddal, Norway

[13 ]Department of Gastroenterology, Oslo University Hospital, Oslo, Norway

[14 ]Institute for Global Health, University College London, London, United Kingdom

[15 ]School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada

[16 ]Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

[17 ]CHIP, World Health Organization Collaborating Centre on HIV and Viral Hepatitis, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Article

DOI: 10.1093/cid/ciz714

PubMed ID: 31352481

SO-VID: e90981ac-a875-437a-9019-90be0ab5477f

License:

https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

The Consensus Hepatitis C Cascade of Care: Standardized Reporting to Monitor Progress Toward Elimination

Read this article at

Abstract

Related collections

UCL: UN SDG 03 Good Health and Well-Being

Most cited references 30

Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

Historical epidemiology of hepatitis C virus (HCV) in selected countries.

The Treatment Cascade for Chronic Hepatitis C Virus Infection in the United States: A Systematic Review and Meta-Analysis

Author and article information

Contributors

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 81

Cited by 23

Most referenced authors 844