Dissociating frontal regions that co-lateralize with different ventral occipitotemporal regions during word processing ^☆

Highlights

• •

  Co-variation in lateralization during word reading dissociated three subsystems.

• •

  Posterior ventral occipito-temporal cortex (vOT) with precentral gyrus.

• •

  Middle vOT with pars opercularis, pars triangularis and supramarginal gyrus.

• •

  Anterior vOT with pars orbitalis, middle frontal gyrus and thalamus.

Abstract

The ventral occipitotemporal sulcus (vOT) sustains strong interactions with the inferior frontal cortex during word processing. Consequently, activation in both regions co-lateralize towards the same hemisphere in healthy subjects. Because the determinants of lateralisation differ across posterior, middle and anterior vOT subregions, we investigated whether lateralisation in different inferior frontal regions would co-vary with lateralisation in the three different vOT subregions. A whole brain analysis found that, during semantic decisions on written words, laterality covaried in (1) posterior vOT and the precentral gyrus; (2) middle vOT and the pars opercularis, pars triangularis, and supramarginal gyrus; and (3) anterior vOT and the pars orbitalis, middle frontal gyrus and thalamus. These findings increase the spatial resolution of our understanding of how vOT interacts with other brain areas during semantic categorisation on words.