DRAMP 2.0, an updated data repository of antimicrobial peptides

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Data Repository of Antimicrobial Peptides (DRAMP, http://dramp.cpu-bioinfor.org/) is an open-access comprehensive database containing general, patent and clinical antimicrobial peptides (AMPs). Currently DRAMP has been updated to version 2.0, it contains a total of 19,899 entries (newly added 2,550 entries), including 5,084 general entries, 14,739 patent entries, and 76 clinical entries. The update covers new entries, structures, annotations, classifications and downloads. Compared with APD and CAMP, DRAMP contains 14,040 (70.56% in DRAMP) non-overlapping sequences. In order to facilitate users to trace original references, PubMed_ID of references have been contained in activity information. The data of DRAMP can be downloaded by dataset and activity, and the website source code is also available on dedicatedly designed download webpage. Although thousands of AMPs have been reported, only a few parts have entered clinical stage. In the paper, we described several AMPs in clinical trials, including their properties, indications and clinicaltrials.gov identifiers. Finally, we provide the applications of DRAMP in the development of AMPs.

Related collections

Most cited references 49

Record: found
Abstract: found
Article: not found

Cyclic peptide therapeutics: past, present and future.

Alessandro Zorzi, Kaycie Deyle, Christian Heinis (2017)

Cyclic peptides combine several favorable properties such as good binding affinity, target selectivity and low toxicity that make them an attractive modality for the development of therapeutics. Over 40 cyclic peptide drugs are currently in clinical use and around one new cyclic peptide drug enters the market every year on average. The vast majority of clinically approved cyclic peptides are derived from natural products, such as antimicrobials or human peptide hormones. New powerful techniques based on rational design and in vitro evolution have enabled the de novo development of cyclic peptide ligands to targets for which nature does not offer solutions. A look at the cyclic peptides currently under clinical evaluation shows that several have been developed using such techniques. This new source for cyclic peptide ligands introduces a freshness to the field, and it is likely that de novo developed cyclic peptides will be in clinical use in the near future.

0 comments Cited 180 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

M. Zasloff (1987)

0 comments Cited 158 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

Jiajun Wang, Xiujing Dou, Jing Song … (2018)

Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely distributed throughout the animal and plant kingdoms. They can protect against a broad array of infection-causing agents, such as bacteria, fungi, parasites, viruses, and tumor cells, and also exhibit immunomodulatory activity. AMPs exert antimicrobial activities primarily through mechanisms involving membrane disruption, so they have a lower likelihood of inducing drug resistance. Extensive studies on the structure-activity relationship have revealed that net charge, hydrophobicity, and amphipathicity are the most important physicochemical and structural determinants endowing AMPs with antimicrobial potency and cell selectivity. This review summarizes the recent advances in AMPs development with respect to characteristics, structure-activity relationships, functions, antimicrobial mechanisms, expression regulation, and applications in food, medicine, and animals.

0 comments Cited 154 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Xingzhen Lao: lao@cpu.edu.cn

Heng Zheng: zhengh18@hotmail.com

Journal

Journal ID (nlm-ta): Sci Data

Journal ID (iso-abbrev): Sci Data

Title: Scientific Data

Publisher: Nature Publishing Group UK (London )

ISSN (Electronic): 2052-4463

Publication date (Electronic): 13 August 2019

Publication date PMC-release: 13 August 2019

Publication date Collection: 2019

Volume: 6

Electronic Location Identifier: 148

Affiliations

[1 ]ISNI 0000 0000 9776 7793, GRID grid.254147.1, School of Life Science and Technology, , China Pharmaceutical University, ; Nanjing, 211100 P.R. China

[2 ]ISNI 0000 0004 1761 0489, GRID grid.263826.b, State Key Laboratory of Bioelectronics, , Southeast University, ; Nanjing, 210096 P.R. China

[3 ]ISNI 0000 0001 0348 3990, GRID grid.268099.c, School of Pharmaceutical Sciences, , Wenzhou Medical University, ; Wenzhou, 325000 P.R. China

[4 ]ISNI 0000 0000 9776 7793, GRID grid.254147.1, The Engineering Research Center of Peptide Drug Discovery and Development, , China Pharmaceutical University, ; Nanjing, 211100 P.R. China

Article

Publisher ID: 154

DOI: 10.1038/s41597-019-0154-y

PMC ID: 6692298

PubMed ID: 31409791

SO-VID: eb0276d7-7a1e-424f-b65a-b23a8bf306d2

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 23 April 2019

Date accepted : 17 July 2019

Funding

Funded by: the Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. KYCX19_0665, No. SJKY19_0697 and No. SJCX18_0270), National Found for Fostering Talents of Basic Science (NFFTBS) (No. J1310032), and Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).