Blog
About

35
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [ n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5- β-D-glucofuranosyl (2→1)- β-D-glucopyranosyl-(2→1)- β-D-glucopyranoside]] and nige-labdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl- β-D-glucopyranosyl (2→1)- β-D-glucopyranosyl (2→1)- β-D-glucopyrano-side], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract. The structures of these new glycosides were elucidated by detailed spectroscopic analyses.

          Related collections

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2018
          : 16
          : 2
          : 125-130
          Affiliations
          1College of Pharmacy and Dentistry, Buraydah Colleges, Buraydah, Al-Qassim, P.O. 31717, Kingdom of Saudi Arabia
          2Phytopharmaceuticals Research Lab, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research (Formerly Faculty of Pharmacy), Jamia Hamdard, POHamdard Nagar, New Delhi-110062, India
          Author notes
          *Corresponding author: Showkat R. Mir, Tel: 91-11-26059688; Fax: 91-11-26059663; E-mail: showkatrmir@ 123456gmail.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30038-4
          10.1016/S1875-5364(18)30038-4
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Ministry of Agriculture for providing New Application for Herbal Research Grant Scheme (NRGS)
          Award ID: NH1014D040
          Funded by: Council for Scientific and Industrial Research (CSIR)
          Award ID: SRF/2012
          This work was supported by the Ministry of Agriculture for providing New Application for Herbal Research Grant Scheme (NRGS) (No. NH1014D040) and the Council for Scientific and Industrial Research (CSIR) (No. SRF/2012).

          Comments

          Comment on this article