Lei Xiong: Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
SoftwareRole: VisualizationRole: Writing – original draftRole: Writing – review &
editing
Xiancheng Chen: Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: Writing – review & editing
Ning Liu: Role: Data curationRole: ResourcesRole: SoftwareRole: Writing – review & editing
Zhen Wang: Role: Data curationRole: MethodologyRole: Writing – review & editing
Baolei Miao: Role: SoftwareRole: Writing – review & editing
Weidong Gan:
ORCID: http://orcid.org/0000-0001-7144-3106
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: Supervision
Dongmei Li: Role: ConceptualizationRole: Formal analysisRole: Project administrationRole: ResourcesRole:
ValidationRole: Writing – review & editing
Hongqian Guo: Role: Resources
Donald P. Bottaro: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
26
September
2017
Publication date Collection: 2017
Volume: 12
Issue: 9
Electronic Location Identifier: e0185337
Affiliations
[1
]
Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University,
Institute of Urology, Nanjing University, Nanjing, China
[2
]
Department of Critical Care Medicine, Nanjing Drum Tower Hospital, Medical School
of Nanjing University, Nanjing, China
[3
]
Immunology and Reproductive Biology Laboratory & State Key Laboratory of Analytical
Chemistry for Life Science, Medical School of Nanjing University, Nanjing, China
[4
]
Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, China
National Institute of Health, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-17-07703
DOI: 10.1371/journal.pone.0185337
PMC ID: 5614571
PubMed ID: 28949976
SO-VID: eb41175f-316e-4892-96c5-bbcab8ba786a
Copyright © © 2017 Xiong et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 81572512
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7144-3106
Weidong Gan
Funded by: funder-id http://dx.doi.org/10.13039/501100004608, Natural Science Foundation of Jiangsu Province;
Award ID: BK20131281
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7144-3106
Weidong Gan
This research was supported by the National Natural Science Foundation of China (ID:
81572512) and Natural Science Foundation of Jiangsu Province (ID: BK20131281). The
websites of the program are
http://www.nsfc.gov.cn/ and
http://www.jstd.gov.cn/. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Carcinomas
Subject:
Renal Cell Carcinoma
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Genitourinary Tract Tumors
Subject:
Renal Cell Carcinoma
Subject:
Research and Analysis Methods
Subject:
Cytogenetic Techniques
Subject:
Fluorescent in Situ Hybridization
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Molecular Probe Techniques
Subject:
Probe Hybridization
Subject:
Fluorescent in Situ Hybridization
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Molecular Probe Techniques
Subject:
Probe Hybridization
Subject:
Fluorescent in Situ Hybridization
Subject:
Research and Analysis Methods
Subject:
Histochemistry and Cytochemistry Techniques
Subject:
Immunohistochemistry Techniques
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunohistochemistry Techniques
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Fusion
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
DNA-binding proteins
Subject:
Transcription Factors
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Gene Regulation
Subject:
Transcription Factors
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Regulatory Proteins
Subject:
Transcription Factors
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Cancer Detection and Diagnosis
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Detection and Diagnosis
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Metastasis
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Basic Cancer Research
Subject:
Metastasis
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Reverse Transcriptase-Polymerase Chain Reaction
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Reverse Transcriptase-Polymerase Chain Reaction