Role of tumor-associated macrophages in the Hexim1 and TGFβ/SMAD pathway, and their influence on progression of prostatic adenocarcinoma.

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Abstract

Hexamethylene bisacetamide-inducible protein 1 (Hexim1) regulates transforming growth factor-β (TGFβ) activity and turnover of SMAD proteins in a cyclin-dependent kinase 9-dependent way. It does so specifically through inhibiting function of this enzyme and by inhibiting the transcriptional activity of positive transcription elongation factor b (P-TEFb). Tumor-associated macrophages (TAMs) play a role in the progression of prostate adenocarcinomas. We investigated the clinicopathological significance of Hexim1, TGFβ, SMAD2, and SMAD7 expression in prostate adenocarcinoma cells, and assessed associations between TAMs density and these proteins.

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Journal ID (iso-abbrev): Pathol. Res. Pract.

Title: Pathology, research and practice

Publisher: Elsevier BV

ISSN (Electronic): 1618-0631

ISSN (Print): 0344-0338

Publication date (Electronic): Feb 2016

Volume: 212

Issue: 2

Affiliations

[1 ] Baskent University Faculty of Medicine, Department of Pathology, 79.sok. No: 7/4 Bahçelievler, 06490 Ankara, Turkey. Electronic address: potkala@hotmail.com.

[2 ] Baskent University Faculty of Medicine, Department of Pathology, 79.sok. No: 7/4 Bahçelievler, 06490 Ankara, Turkey. Electronic address: handan27@hotmail.com.

[3 ] Baskent University Faculty of Medicine, Department of Pathology, 79.sok. No: 7/4 Bahçelievler, 06490 Ankara, Turkey. Electronic address: edaakcay@gmail.com.

[4 ] Baskent University Faculty of Medicine, Department of Pathology, 79.sok. No: 7/4 Bahçelievler, 06490 Ankara, Turkey. Electronic address: ozlem-ataol@hotmail.com.

[5 ] Baskent University Faculty of Medicine, Department of Biostatistics, Bağlıca Kampüsü Eskişehir Yolu 20.km Bağlıca, 06810 Ankara, Turkey. Electronic address: matekindal@gmail.com.

[6 ] Baskent University Faculty of Medicine, Department of Urology, 79.sok. No: 7/4 Bahçelievler, 06490 Ankara, Turkey. Electronic address: ozkardes@baskent.edu.tr.

Article

Publisher Item ID: S0344-0338(15)30030-3

DOI: 10.1016/j.prp.2015.10.011

PubMed ID: 26608417

SO-VID: eb42abf7-9034-409e-ad27-3e3fc80f6014

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Keywords: SMAD7,SMAD2,Hexim1,Tumor-associated macrophages (TAMs),TGFβ/SMAD pathway

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Keywords: SMAD7, SMAD2, Hexim1, Tumor-associated macrophages (TAMs), TGFβ/SMAD pathway

Role of tumor-associated macrophages in the Hexim1 and TGFβ/SMAD pathway, and their influence on progression of prostatic adenocarcinoma.

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