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Colchicine prophylaxis in familial Mediterranean fever: Reappraisal after 15 years
February 1991
February 1991
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Abstract
As determined in this study of 45 patients, the prolonged use of colchicine therapy
in familial Mediterranean fever (FMF) is safe and effective in preventing flares of
FMF and amyloidosis. It has acceptable adverse effect profile and can be used in children
and pregnant women. Its discontinuation predisposes patients to acute FMF attacks
and the development of amyloidosis. Articular involvement is less responsive to colchicine
and may require therapy with nonsteroidal antiinflammatory drugs.