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Abstract
Four potent angiotensin converting enzyme (ACE) inhibitory peptides, IY, RIY, VW and
VWIS, were isolated from subtilisin digest of rapeseed protein. Among them RIY and
VWIS are new peptides with IC(50) 28 and 30 microM, respectively. All isolated peptides
lowered blood pressure of spontaneously hypertensive rats (SHR) following oral administration.
The maximum effect in the case of RIY was observed 4h after administration, while
maximum effect of other peptides on blood pressure occurred 2h after administration.
Furthermore, the antihypertensive effect of RIY was observed even in old rats, in
which ACE inhibitors become less effective, suggesting that a different mechanism
other than ACE inhibition is also involved in lowering blood pressure by this peptide.
Subtilisin digest of rapeseed protein also significantly lowered blood pressure of
SHR after oral administration of a single dosage 0.15 g/kg, exerting maximum antihypertensive
effect 4h after administration. This digest appears promising as a functional food,
which may be useful in the prevention and treatment of hypertension.