Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials.

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Abstract

Following a drug repurposing approach, we aimed to investigate and compare the antibacterial and antibiofilm activities of different classes of phosphate prodrugs (HepDirect, cycloSal, SATE and mix SATE) of antiviral and anticancer FDA-approved nucleoside drugs [zidovudine (AZT), floxouridine (FUDR) and gemcitabine (GEM)] against a variety of pathogenic Gram-positive and -negative bacteria.

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Journal

Journal ID (iso-abbrev): J Antimicrob Chemother

Title: The Journal of antimicrobial chemotherapy

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2091

ISSN (Print): 0305-7453

Publication date (Electronic): Oct 01 2020

Volume: 75

Issue: 10

Affiliations

[1 ] School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.

[2 ] Public Health Wales Microbiology Cardiff, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK.

[3 ] Centre of Microbial and Plant Genetics, Kasteelpark Arenberg 20, bus 2460, B-3001 Leuven, Belgium.

[4 ] Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49-box 1043, Leuven 3000, Belgium.

Article

Publisher Item ID: 5874080

DOI: 10.1093/jac/dkaa268

PubMed ID: 32688391

SO-VID: ed9081bb-0125-486a-a1a9-a149ddcbcd74

Copyright © © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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