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      Disruption of the Blood-Aqueous Barrier following Retinal Laser Photocoagulation and Cryopexy in Pigmented Rabbits

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          Abstract

          Disruption of the blood-aqueous barrier (BAB) induced by retinal photocoagulation and cryopexy in pigmented rabbits was evaluated by laser flare photometry. A significant increase in flare values after retinal photocoagulation was measured from the 1st postoperative day, with values returning to baseline levels by day 7. Cryopexy induced consistently high flare values for 14 days. Intravitreal injection of interleukin (IL) 1, IL-6 and prostaglandin (PG) E<sub>2</sub> induced a significant increase in flare values. Following these treatments, introduction of a PG synthetase inhibitor can partially ameliorate BAB disruption. IL-1, IL-6 and PGE<sub>2</sub> may be involved in BAB disruption following retinal photocoagulation and cryopexy.

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          Studies on intraocular inflammation produced by intravitreal human interleukins in rabbits.

          P S Kulkarni, M Mancino (1993)
          Recombinant human interleukin-1 alpha, interleukin-1 beta (10, 80 or 200 units), interleukin-8 (10 or 40 units) or endotoxin was injected intravitreally into rabbit eyes. Twenty-four hours thereafter aqueous humor protein, leukocyte number, prostaglandin E2, leukotriene B4 and rabbit interleukin-1 beta were measured. In addition, synthesis of prostaglandin E2 and leukotriene B4 in iris-ciliary body and myeloperoxidase (MPO) activity were determined. Recombinant human interleukins 1 alpha and 1 beta, but not interleukin-8 induced signs of uveitis, i.e. protein and leukocytic infiltration into aqueous humor. At 200 unit activities, human interleukin-1 beta was significantly greater than interleukin-1 alpha in causing leukocyte infiltration response. Interleukin-1 alpha did not stimulate the release of prostaglandin E2 or leukotriene B4. In fact, interleukin-1 beta significantly inhibited the synthesis of prostaglandin E2 in iris-ciliary body. Both of these human interleukins caused a release of rabbit interleukin-1 beta in aqueous achieving a level significantly higher than observed after endotoxin injection. This study demonstrates that intravitreal injections of human IL-1 alpha and IL-1 beta induce uveitis by releasing rabbit interleukin-1 beta within the eye.
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            Author and article information

            Journal
            Journal ID (publisher-id): ORE
            Journal ID (nlm-ta): Ophthalmic Res
            Journal ID (doi): 10.1159/issn.0030-3747
            Title: Ophthalmic Research
            Publisher: S. Karger AG
            ISSN (Print): 0030-3747
            ISSN (Electronic): 1423-0259
            Publication date Subscription-year: 2001
            Publication date (Print): February 2001
            Publication date (Electronic): 13 December 2000
            Volume: 33
            Issue: 1
            Pages: 37-41
            Affiliations
            Department of Ophthalmology, Kobe University School of Medicine, Kobe, Japan
            Article
            Publisher ID: 55639 Other ID: Ophthalmic Res 2001;33:37–41
            DOI: 10.1159/000055639
            PubMed ID: 11114603
            SO-VID: eda6ff32-74ee-4486-ae49-c59764743ffc
            Copyright © © 2001 S. Karger AG, Basel
            License:

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Figures: 6, References: 27, Pages: 5
            Categories
            Subject: Original Paper

            ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
            Keywords: Prostaglandin synthetase inhibitor,Cryopexy,Laser flare photometry,Interleukin,Prostaglandin,Photocoagulation
            Data availability:
            ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
            Keywords: Prostaglandin synthetase inhibitor, Cryopexy, Laser flare photometry, Interleukin, Prostaglandin, Photocoagulation

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