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      Disruption of the Blood-Aqueous Barrier following Retinal Laser Photocoagulation and Cryopexy in Pigmented Rabbits


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          Disruption of the blood-aqueous barrier (BAB) induced by retinal photocoagulation and cryopexy in pigmented rabbits was evaluated by laser flare photometry. A significant increase in flare values after retinal photocoagulation was measured from the 1st postoperative day, with values returning to baseline levels by day 7. Cryopexy induced consistently high flare values for 14 days. Intravitreal injection of interleukin (IL) 1, IL-6 and prostaglandin (PG) E<sub>2</sub> induced a significant increase in flare values. Following these treatments, introduction of a PG synthetase inhibitor can partially ameliorate BAB disruption. IL-1, IL-6 and PGE<sub>2</sub> may be involved in BAB disruption following retinal photocoagulation and cryopexy.

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          Studies on intraocular inflammation produced by intravitreal human interleukins in rabbits.

          Recombinant human interleukin-1 alpha, interleukin-1 beta (10, 80 or 200 units), interleukin-8 (10 or 40 units) or endotoxin was injected intravitreally into rabbit eyes. Twenty-four hours thereafter aqueous humor protein, leukocyte number, prostaglandin E2, leukotriene B4 and rabbit interleukin-1 beta were measured. In addition, synthesis of prostaglandin E2 and leukotriene B4 in iris-ciliary body and myeloperoxidase (MPO) activity were determined. Recombinant human interleukins 1 alpha and 1 beta, but not interleukin-8 induced signs of uveitis, i.e. protein and leukocytic infiltration into aqueous humor. At 200 unit activities, human interleukin-1 beta was significantly greater than interleukin-1 alpha in causing leukocyte infiltration response. Interleukin-1 alpha did not stimulate the release of prostaglandin E2 or leukotriene B4. In fact, interleukin-1 beta significantly inhibited the synthesis of prostaglandin E2 in iris-ciliary body. Both of these human interleukins caused a release of rabbit interleukin-1 beta in aqueous achieving a level significantly higher than observed after endotoxin injection. This study demonstrates that intravitreal injections of human IL-1 alpha and IL-1 beta induce uveitis by releasing rabbit interleukin-1 beta within the eye.

            Author and article information

            Ophthalmic Res
            Ophthalmic Research
            S. Karger AG
            February 2001
            13 December 2000
            : 33
            : 1
            : 37-41
            Department of Ophthalmology, Kobe University School of Medicine, Kobe, Japan
            55639 Ophthalmic Res 2001;33:37–41
            © 2001 S. Karger AG, Basel

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            Page count
            Figures: 6, References: 27, Pages: 5
            Original Paper

            Vision sciences,Ophthalmology & Optometry,Pathology
            Prostaglandin synthetase inhibitor,Cryopexy,Laser flare photometry,Interleukin,Prostaglandin,Photocoagulation


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