Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice.

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Abstract

Previous work provided indirect evidence that the neurotrophic factor neurturin (NRTN) is required for normal cholinergic innervation of the heart. This study used nrtn knockout (KO) and wild-type (WT) mice to determine the effect of nrtn deletion on cardiac cholinergic innervation and function in the adult heart.

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Journal

Journal ID (iso-abbrev): Cardiovasc. Res.

Title: Cardiovascular research

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1755-3245

ISSN (Print): 0008-6363

Publication date (Electronic): Apr 01 2009

Volume: 82

Issue: 1

Affiliations

[1 ] Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.

Article

Publisher Item ID: cvp029

DOI: 10.1093/cvr/cvp029

PubMed ID: 19176599

SO-VID: ee01a357-e242-4b74-bfc4-52d1e3dac493

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