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      Localization of 8-Methoxypsoralen in Ocular Tissues

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          Abstract

          UVA radiation results in the generation of 8-methoxypsoralen (8-MOP) photoproducts which can be permanently retained in the rat and dogfish lenses and retinas as demonstrated by phosphorescence and EPR spectroscopy, autoradiography and radioactivity of labeled products in these tissues. 8-MOP photoproducts also develop in the corneal epithelium but these cells are replaced within 3–4 days. These experiments suggest that photobound 8-MOP products could accumulate in human lenses and in aphakic or young retinas. Such photoproducts can be prevented by proper UV filtering glasses worn for at least 24 h after ingestion of 8-MOP.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1981
          1981
          04 December 2009
          : 13
          : 2
          : 106-116
          Affiliations
          Department of Ophthalmology and Pathology, Emory University, and Division of Dermatology, Veterans Administration Hospital, Atlanta, Ga., USA
          Article
          265138 Ophthalmic Res 1981;13:106–116
          10.1159/000265138
          ee8b0906-d8c3-4965-9740-9f8bc97c228c
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 22 March 1980
          : 23 June 1980
          Page count
          Pages: 11
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Retina,UV radiation,8-Methoxypsoralen,Photosensitizer,Aphakic,Lens

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