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      Associations between Anxiety and Depression Symptoms and Medical Care Avoidance during COVID-19

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      , PhD, MSW 1 , , , MD, MPH 2 , , MD 3 , 4 , , MD, MSc 5
      Journal of General Internal Medicine
      Springer International Publishing

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          Abstract

          INTRODUCTION Since the outbreak of the novel coronavirus disease 2019 (COVID-19) pandemic, emergency health care utilization has acutely declined by 23% for heart attacks, 20% for strokes, and 10% for hyperglycemic crises. 1 Ambulatory visits have also declined by nearly 60%. 2 The lack of health care utilization is concerning as it may result in significant medical complications resulting from untreated medical problems. 1 Little is known about what is driving these declines in health care utilization. A study from Italy suggested that fear of COVID-19 infection may be one such factor. 3 Recent research has documented pervasive anxiety and depression during the COVID-19 pandemic. 4, 5 We conducted this study to estimate the association between mental health symptoms and medical care avoidance among US adults. METHODS We analyzed data from June 11–June 16, 2020, of the weekly, cross-sectional Household Pulse Survey (HPS; n = 73,472) which is conducted by the US Census Bureau in collaboration with five other federal agencies to produce data on the social and economic impacts of COVID-19 among adults in the USA. The HPS questionnaire was reviewed by independent experts at the Center for Behavioral Science Methods, as well as the Demographic Directorate and subject matter representatives from the five partner federal agencies. To gather the sample, HPS used the Census Bureau’s Master Address File as the primary sampling frame to collect responses from a large sample that is sufficient for the anticipated low responses rates. The Census Bureau used the online platform Qualtrics as the primary data collection method. See the Census Bureau website (https://www.census.gov/householdpulsedata) for more information and access to publicly available data. We fitted modified multivariable Poisson regression models to estimate the associations between four mental health symptoms (nervous, anxious, or on edge; not being able to stop or control worrying; little interest or pleasure in doing things; feeling down, depressed, or hopeless) in the past 7 days and medical care avoidance (delayed medical care; needed non-coronavirus medical care but did not get it) due to the coronavirus pandemic in the past 4 weeks. The use of robust estimates of variance permits straightforward interpretation of the exponentiated regression coefficients as risk ratios. We adjusted for potential confounding by age, sex, race/ethnicity, income, education, employment loss, and marital status. Nonresponse sample weighing was applied. Analyses were conducted using Stata 15.1. RESULTS Demographic and descriptive results are displayed in Table 1. Individuals who experience all four symptoms of anxiety and depression had higher adjusted relative risk ratios of delayed medical care and not receiving needed non-coronavirus medical care, after adjustment for potential confounders (Table 2). Individuals who were nervous, anxious, or on edge in the past 7 days had the highest adjusted relative risk ratio of delayed medical care (1.95, 95% CI 1.83–2.09) and the highest adjusted relative risk ratio of not receiving needed non-coronavirus medical care (2.08, 95% CI 1.93–2.25). Table 1 Weighted Sample Characteristics of Week 7 of US Census Household Pulse Survey (n = 73,472) Mean ± SE/% Age 48.09 ± 0.20 Sex   Female 51.6 Race/ethnicity   Hispanic or Latino (may be of any race) 16.9   White alone, not Hispanic 62.8   Black alone, not Hispanic 11.2   Asian alone, not Hispanic 5.0   Two or more races + other races, not Hispanic 4.1 Income   Less than $25,000 16.5   $25,000–$34,999 12.0   $35,000–$49,999 12.5   $50,000–$74,999 18.1   $75,000–$99,999 12.9   $100,000–$149,999 14.8   $150,000–$199,999 6.4   $200,000 and above 6.7 Education   Bachelor’s degree or higher 30.4 Employment loss, past 7 days   Yes 47.8 Marital status   Not married 55.1 Medical care avoidance Delayed medical care due to coronavirus, 4 weeks†   Yes 41.0 Needed non-coronavirus medical care but did not get it, past 4 weeks‡   Yes 32.2 Mental health symptoms Nervous, anxious, or on edge, past 7 days§   Any days 65.0 Not being able to stop or control worrying, past 7 days‖   Any days 56.1 Little interest or pleasure in doing things, past 7 days¶   Any days 53.3 Feeling down, depressed, or hopeless, past 7 days#   Any days 52.2 June 11–June 16, 2020 †“At any time in the last 4 weeks, did you DELAY getting medical care because of the coronavirus pandemic?” ‡“At any time in the last 4 weeks, did you need medical care for something other than coronavirus, but DID NOT GET IT because of the coronavirus pandemic?” §“Over the last 7 days, how often have you been bothered by the following problems ... Feeling nervous, anxious, or on edge?” ‖“Over the last 7 days, how often have you been bothered by the following problems ... Not being able to stop or control worrying?” ¶“Over the last 7 days, how often have you been bothered by ... having little interest or pleasure in doing things?” #“Over the last 7 days, how often have you been bothered by ... feeling down, depressed, or hopeless?” Table 2 Adjusted Relative Risk Ratios of Mental Health Symptoms and Medical Care Avoidance Delayed medical care* p Did not get medical carea p Adjusted relative risk ratio (95% CI) Adjusted relative risk ratio (95% CI) Nervous, anxious, or on edge, past 7 days 1.95 (1.83–2.09) 0.001 2.08 (1.93–2.25) 0.001 Not being able to stop or control worrying, past 7 days 1.83 (1.73–1.94) 0.001 2.05 (1.92–2.00) 0.001 Little interest or pleasure in doing things, past 7 days 1.69 (1.60–1.79) 0.001 1.90 (1.78–2.03) 0.001 Feeling down, depressed, or hopeless, past 7 days 1.67 (1.58–1.76) 0.001 1.89 (1.77–2.02) 0.001 *Each column displays estimates from a single multivariable Poisson regression model with additional covariate adjustment for age, sex, race/ethnicity, income, education, employment loss, and marital status. As described by Zou (Am J Epidemiol. 2004;159:702–706), the modified Poisson model permits interpretation of the exponentiated regression coefficients as risk ratios rather than incidence rate ratios. DISCUSSION In this population-based study of US adults from June 11–16, 2020, we show that mental health symptoms are strongly correlated with medical care avoidance amidst the COVID-19 pandemic. Our results revealed significantly higher adjusted relative risk ratios of medical care avoidance among US adults who experience common symptoms of anxiety and depression. Importantly, our results show that individuals who experience these symptoms are more likely to avoid seeking non-coronavirus medical care despite needing it, which is concerning as delayed medical care may result in significant adverse short- and long-term health outcomes for many conditions. 1 Our results provide support for accurate and effective translation of knowledge to the public about the risks and benefits of seeking needed medical care during the ongoing COVID-19 pandemic. Of particular importance is the expansion of health insurance policies to cover telehealth services 6 and continued efforts to implement telehealth services to address non-emergency medical concerns. Additionally, a continued increase in telepsychiatry and telemental health services is needed to assist US adults in managing mental health symptoms for the duration of the COVID-19 pandemic.

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          The outbreak of COVID-19 coronavirus and its impact on global mental health

          The current outbreak of COVID-19 coronavirus infection among humans in Wuhan (China) and its spreading around the globe is heavily impacting on the global health and mental health. Despite all resources employed to counteract the spreading of the virus, additional global strategies are needed to handle the related mental health issues. Published articles concerning mental health related to the COVID-19 outbreak and other previous global infections have been considered and reviewed. This outbreak is leading to additional health problems such as stress, anxiety, depressive symptoms, insomnia, denial, anger and fear globally. Collective concerns influence daily behaviors, economy, prevention strategies and decision-making from policy makers, health organizations and medical centers, which can weaken strategies of COVID-19 control and lead to more morbidity and mental health needs at global level.
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            Telehealth for global emergencies: Implications for coronavirus disease 2019 (COVID-19)

            The current coronavirus (COVID-19) pandemic is again reminding us of the importance of using telehealth to deliver care, especially as means of reducing the risk of cross-contamination caused by close contact. For telehealth to be effective as part of an emergency response it first needs to become a routinely used part of our health system. Hence, it is time to step back and ask why telehealth is not mainstreamed. In this article, we highlight key requirements for this to occur. Strategies to ensure that telehealth is used regularly in acute, post-acute and emergency situations, alongside conventional service delivery methods, include flexible funding arrangements, training and accrediting our health workforce. Telehealth uptake also requires a significant change in management effort and the redesign of existing models of care. Implementing telehealth proactively rather than reactively is more likely to generate greater benefits in the long-term, and help with the everyday (and emergency) challenges in healthcare.
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              Delayed access or provision of care in Italy resulting from fear of COVID-19

              During Italy's national lockdown for coronavirus disease 2019 (COVID-19), official hospital statistics in the period March 1–27, 2020, show substantial decreases—ranging from 73% to 88%—in paediatric emergency department visits compared with the same time period in 2019 and 2018 (figure ). Similarly, family paediatricians widely report a considerable reduction in clinic visits, although this is difficult to measure precisely. Figure Visits to paediatric emergency departments across five hospitals in Italy, March 1–27, 2020, compared with the same period in 2018 and 2019 Data are official hospital statistics (courtesy of the authors). Schools and sports activities have been closed since March 1 in Italy, so it is understandable that the numbers of acute infections and traumas among children are lower than usual. In addition, relatively few cases of COVID-19 among children have been reported. 1 As of April 2, the 1624 cases in the paediatric population ( 39°C) and the other presented with severe anaemia (haemoglobin 4·2 mg/dL) and respiratory distress after emergency department access was delayed. One of these patients died several days after hospital admission. One child presented with long-lasting convulsions after three previous episodes of convulsions had been treated at home without medical assistance; the patient was eventually diagnosed with bacterial pneumonia. A 3-year-old girl was admitted to hospital after 6 days at home with very high fever (>39°C), with a sepsis secondary to a pyelonephritis. A neonate was kept home despite vomiting for several days because of hypertrophic pyloric stenosis and arrived in the emergency department in hypovolaemic shock. Another child, aged 2 years, had been vomiting for several days and unable to eat before presenting with severe hypoglycaemia. One child arriving in the emergency department having been unable to pass faeces for more than a week was diagnosed with an abdominal mass of 15 cm diameter, later diagnosed as Wilm's tumour; the diagnosis by telephone from his paediatrician had been functional constipation. An adolescent with cerebral palsy and severe malnutrition got in touch with the hospital after 10 days of fever at home with increased oxygen needs, and died in the ambulance on the way to the hospital. The precise cause of fever and death was not ascertained but the adolescent was negative for COVID-19 infection. Another child with cerebral palsy, tracheotomy, and enteral nutrition died on route to the hospital after 3 days of bloody stools. A child with Mowat Wilson syndrome, in dialysis for chronic renal insufficiency, arrived at the hospital after 3 days of being “less active than usual” with capillary refill time of 4 s, heart rate of 50 beats per min, oxygen saturation level not detectable, mixed acidosis, and creatine 4 mg/dL; the child died after 4 days in the ICU. Of this small series of 12 cases, half of the children were admitted to an ICU and four died. In all cases, parents reported avoiding accessing hospital because of fear of infection with SARS-CoV-2. Furthermore, in five cases, the family had contacted health services before accessing care, but their health provider was unavailable because of the COVID-19 epidemic, or hospital access was discouraged because of the possible risk of infection. All cases were either negative for SARS-CoV-2 or had a clinical presentation (eg, diabetes) that did not justify a diagnostic test according to the national criteria. Notably, no death occurred in the same hospitals during the same period in 2019, and the total yearly number of paediatric deaths in these hospitals ranges from zero to three. These cases are clearly a small sample compared with the overall number of paediatric visits recorded in the five hospitals during this week (12 [2%] of 502). However, since delay in access to care was not monitored systematically, this small case series might underestimate the problem. We believe that further monitoring of access to routine clinical care is needed during the COVID-19 pandemic. There is a need to prevent delays in accessing hospital care and to increase provision of high-quality coordinated care by health-care providers. Both of these aspects should be considered as part of the overall public health impact of the COVID-19 pandemic, as evident in other epidemics,3, 4 and must be adequately monitored. Both the general population and health-care workers need clear guidance and information. Specifically, parents should be made fully aware that the risks of delayed access to hospital care for emergency conditions can be much higher than those posed by COVID-19. Specific duties and obligations of different types of health-care professionals should be clearly defined, taking into consideration the risk level of the working environment, the health-care worker's specialty, the probable harms and benefits of treatment, and competing obligations deriving from workers' multiple roles.4, 5
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                Author and article information

                Contributors
                kyle.ganson@utoronto.ca
                Journal
                J Gen Intern Med
                J Gen Intern Med
                Journal of General Internal Medicine
                Springer International Publishing (Cham )
                0884-8734
                1525-1497
                1 September 2020
                : 1-3
                Affiliations
                [1 ]GRID grid.17063.33, ISNI 0000 0001 2157 2938, Factor-Inwentash Faculty of Social Work, , University of Toronto, ; Toronto, ON Canada
                [2 ]GRID grid.266102.1, ISNI 0000 0001 2297 6811, Division of HIV, Infectious Diseases and Global Medicine, School of Medicine, , University of California, San Francisco, ; San Francisco, CA USA
                [3 ]GRID grid.32224.35, ISNI 0000 0004 0386 9924, Center for Global Health and Mongan Institute, , Massachusetts General Hospital, ; Boston, MA USA
                [4 ]GRID grid.38142.3c, ISNI 000000041936754X, Harvard Medical School, ; Boston, MA USA
                [5 ]GRID grid.266102.1, ISNI 0000 0001 2297 6811, Division of Adolescent and Young Adult Medicine, Department of Pediatrics, , University of California, San Francisco, ; San Francisco, CA USA
                Author information
                http://orcid.org/0000-0003-3889-3716
                Article
                6156
                10.1007/s11606-020-06156-8
                7462353
                32875507
                eec8d3e1-5ac4-46e6-98a8-ac7b90908e73
                © Society of General Internal Medicine 2020

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 20 July 2020
                : 14 August 2020
                Funding
                Funded by: Sullivan Family Foundation
                Award ID: N/A
                Award Recipient :
                Categories
                Concise Research Report

                Internal medicine
                Internal medicine

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