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Systematic review of lymphoma in oral cavity and maxillofacial region

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      Abstract

      The aim of this paper is to determine, compare and summarize presentation characteristics of patients with lymphoma of the oral cavity and maxillofacial region using the results of different primary studies. Articles from the PubMed database published between 1990 and 2010 were reviewed. The key words “Lymphoma” and “Oral” were used to search for titles, identifying 215 articles, of which 178 were excluded and 37 were used for this review. After evaluation, the researchers agreed to include 15 of the papers in the study. This paper describes the author, year published, number of cases, sex, age, location, signs and symptoms, classification, diagnosis, staging and treatment reported in each of the 15 studies. A total 714 patients are described. In 11 out of 13 studies, there were more cases in males than females. Ages ranged from 3 to 96 years. Presentation was most frequently the gingiva and the main sign was swelling. Staging was described for only 177 cases and treatment was described for only 110 cases. It is concluded that the presentation of most of the lymphomas of the oral cavity and maxillofacial region is extranodal, non-Hodgkin’s. The most common locations are gingiva in the oral activity and Waldeyers’s ring in the maxillofacial region. Although these lymphomas are rare pathological entities, it is important to describe the complete manifestation of their natural history in order to provide knowledge of their development.

      Translated abstract

      El objetivo del presente trabajo fue determinar, las características de presentación de pacientes con linfoma en la cavidad oral y la región maxilofacial para comparar estas presentaciones y permitir sintetizar los resultados provenientes de diversos estudios primarios. Fueron incluidos artículos de la base de datos PubMed desde el año 1990 hasta el año 2010. Se incluyeron como palabras claves en el título de los artículos: “Lymphoma” y “Oral”. Se identificaron 215 artículos de los que fueron excluidos 178 estudios quedando para este estudio 37 artículos. Los investigadores evaluaron estos artículos alcanzando un acuerdo para la inclusión de 15 artículos para este estudio. Se describe de los 15 estudios autor, año de publicación del estudio, número de casos, sexo, edad, localización, signos y síntomas, clasificación, diagnóstico, estadiaje y tratamiento. Un total de 714 pacientes se describen siendo en 11 de 13 estudios el mayor número de casos en hombres que mujeres; la edad estuvo en un rango de 3 a 96 años. La localización de mayor presentación fue la gingiva y el aumento de volumen fue el principal signo. Solo de 177 casos fueron descritos su estadiaje y solo de 110 casos su tratamiento. Se concluye que los linfomas de la cavidad oral y la región maxilofacial son de mayor presentación del tipo no Hodgkin, a nivel extranodal. La gingiva en la cavidad oral y el anillo de Waldeyer en la región maxilofacial son las localizaciones más comunes. Son entidades patológicas raras, pero la descripción de la historia natural de esta patología en su completa manifestación es importante para el conocimiento del desarrollo de esta enfermedad.

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      Most cited references 38

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      A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.

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        Updated Kiel classification for lymphomas.

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          Oral non-Hodgkin's lymphoma: review of the literature and World Health Organization classification with reference to 40 cases.

          Forty cases of oral cavity non-Hodgkin's lymphoma (NHL) were evaluated for sex, age, location, clinical presentation, and World Health Organization (WHO) histological subtype. Fifty-three percent were female and the mean age was 71. The upper jaw (maxilla or palatal bone), mandible, palatal soft tissue, and vestibule and gingivae (maxillary or mandibular soft tissue involvement only) were, respectively, the most common locations. Swelling, ulceration, and radiographic destruction of bone were the most frequent signs. Most of the lymphomas were of B cell lineage (98%), and the majority of these B cell lymphomas (58%) were histologically subtyped as diffuse large B cell lymphoma, which is considered to have an aggressive clinical course. An immunohistochemical panel was used in the majority of cases to confirm the lineage and to help characterize the subtype. B and T cell specific markers were used to show lineage of the neoplastic cells. Additional markers were used to help confirm specific subtypes that characteristically show specific positivity to some of these antibodies. Molecular studies to detect monoclonal immunoglobulin heavy chain (IgH) gene rearrangements and Bcl-1 and Bcl-2 gene translocations were performed in cases in which the diagnosis was in question. The current WHO classification is also reviewed in detail.
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            Author and article information

            Affiliations
            Lima orgnamePeruvian University Cayetano Heredia Peru
            Minas Gerais orgnameFederal University of Juiz de Fora Brazil
            Lima orgnameUniversity of San Martín de Porres Peru
            Contributors
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Journal
            aol
            Acta Odontológica Latinoamericana
            Acta odontol. latinoam.
            Sociedad Argentina de Investigación Odontológica (Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina )
            1852-4834
            December 2011
            : 24
            : 3
            : 245-251
            S1852-48342011000300005

            This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

            Counts
            Figures: 0, Tables: 0, Equations: 0, References: 38, Pages: 7
            Product
            Product Information: SciELO Argentina

            Linfoma, Oral, Revisión, Lymphoma, Mouth, Review

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