For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
42
views
178
references
 Top references
cited by
15
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      141
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.

          Related collections

          Most cited references178

          • Record: found
          • Abstract: found
          • Article: not found

          G-protein-coupled receptors and signaling networks: emerging paradigms.

          Maria Julia Marinissen, J.Silvio Gutkind (2001)
          G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules involved in signal transmission. These receptors play key physiological roles and their dysfunction results in several diseases. Recently, it has been shown that many of the cellular responses mediated by GPCRs do not involve the sole stimulation of conventional second-messenger-generating systems, but instead result from the functional integration of an intricate network of intracellular signaling pathways. Effectors for GPCRs that are independent of G proteins have now also been identified, thus changing the conventional view of the GPCR-heterotrimeric-G-protein-associated effector. The emerging information is expected to help elucidate the most basic mechanism by which these receptors exert their numerous physiological roles, in addition to determining why the perturbation of their function results in many pathological conditions.
          Article 0 comments Cited 175 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.

            Keijo T Mäkelä, Ismo Virtanen, Tomi P Mäkelä … (2002)
            Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption, and also serve as a major route for tumor metastasis in many types of cancer. We found that isolated human primary lymphatic and blood vascular endothelial cells (LECs and BECs, respectively) show interesting differences in gene expression relevant for their distinct functions in vivo. Although these phenotypes are stable in vitro and in vivo, overexpression of the homeobox transcription factor Prox-1 in the BECs was capable of inducing LEC-specific gene transcription in the BECs, and, surprisingly, Prox-1 suppressed the expression of approximately 40% of the BEC-specific genes. Prox-1 did not have global effects on the expression of LEC-specific genes in other cell types, except that it up-regulated cyclin E1 and E2 mRNAs and activated the cyclin e promoter in various cell types. These data suggest that Prox-1 acts as a cell proliferation inducer and a fate determination factor for the LECs. Furthermore, the data provide insights into the phenotypic diversity of endothelial cells and into the possibility of transcriptional reprogramming of differentiated endothelial cells.
            Article 0 comments Cited 124 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial.

              Alan Maisel, Christian R. Mueller, Richard Nowak … (2010)
              Our purpose was to assess the diagnostic utility of mid-regional pro-atrial natriuretic peptide (MR-proANP) for the diagnosis of acute heart failure (AHF) and the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with AHF. There are some caveats and limitations to natriuretic peptide testing in the acute dyspneic patient. The BACH (Biomarkers in Acute Heart Failure) trial was a prospective, 15-center, international study of 1,641 patients presenting to the emergency department with dyspnea. A noninferiority test of MR-proANP versus B-type natriuretic peptide (BNP) for diagnosis of AHF and a superiority test of MR-proADM versus BNP for 90-day survival were conducted. Other end points were exploratory. MR-proANP (> or =120 pmol/l) proved noninferior to BNP (> or =100 pg/ml) for the diagnosis of AHF (accuracy difference 0.9%). In tests of secondary diagnostic objectives, MR-proANP levels added to the utility of BNP levels in patients with intermediate BNP values and with obesity but not in renal insufficiency, the elderly, or patients with edema. Using cut-off values from receiver-operating characteristic analysis, the accuracy to predict 90-day survival of heart failure patients was 73% (95% confidence interval: 70% to 77%) for MR-proADM and 62% (95% confidence interval: 58% to 66%) for BNP (difference p < 0.001). In adjusted multivariable Cox regression, MR-proADM, but not BNP, carried independent prognostic value (p < 0.001). Results were consistent using NT-proBNP instead of BNP (p < 0.001). None of the biomarkers was able to predict rehospitalization or visits to the emergency department with clinical relevance. MR-proANP is as useful as BNP for AHF diagnosis in dyspneic patients and may provide additional clinical utility when BNP is difficult to interpret. MR-proADM identifies patients with high 90-day mortality risk and adds prognostic value to BNP. (Biomarkers in Acute Heart Failure [BACH]; NCT00537628). Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
              Article 0 comments Cited 119 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Curr Hypertens Rev
                Journal ID (iso-abbrev): Curr Hypertens Rev
                Journal ID (publisher-id): CHR
                Title: Current Hypertension Reviews
                Publisher: Bentham Science Publishers
                ISSN (Print): 1573-4021
                ISSN (Electronic): 1875-6506
                Publication date (Print): December 2011
                Publication date (Electronic): December 2011
                Volume: 7
                Issue: 4
                Pages: 228-239
                Affiliations
                [1 ]Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
                [2 ]Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
                Author notes
                [* ]Address correspondence to this author at the The University of North Carolina at Chapel Hill, 111 Mason Farm Road, 6330 MBRB, Chapel Hill, North Carolina 27599; Tel: 919-966-5193; Fax: 919-966-5230; E-mail: kathleen_caron@ 123456med.unc.edu
                [#]

                Authors contributed equally to this work

                Article
                Publisher ID: CHR-7-228
                DOI: 10.2174/157340211799304761
                PMC ID: 3349984
                PubMed ID: 22582036
                SO-VID: ef288919-c4ef-4753-aa91-256a10151c83
                Copyright © © 2011 Bentham Science Publishers
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 6 June 2011
                Date revision received : 18 August 2011
                Date accepted : 21 August 2011
                Categories
                Subject: Article

                ScienceOpen disciplines: Cardiovascular Medicine
                Keywords: endothelial,clr,angiogenesis,permeability,lymphangiogenesis,ramps.,adrenomedullin,mouse model
                Data availability:
                ScienceOpen disciplines: Cardiovascular Medicine
                Keywords: endothelial, clr, angiogenesis, permeability, lymphangiogenesis, ramps., adrenomedullin, mouse model

                Comments

                Comment on this article

                scite_

                Similar content141

                See all similar

                Cited by13

                See all cited by

                Most referenced authors1,758

                See all reference authors