Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans.

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Abstract

Alcohol-related liver disease (ALD) is a global healthcare problem with limited treatment options. Alpha-1 antitrypsin (AAT, encoded by SERPINA1) shows potent anti-inflammatory activities in many preclinical and clinical trials. In our study, we aimed to explore the role of AAT in ALD.

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Journal

Journal ID (iso-abbrev): Gut

Title: Gut

Publisher: BMJ

ISSN (Electronic): 1468-3288

ISSN (Print): 0017-5749

Publication date (Electronic): Mar 2021

Volume: 70

Issue: 3

Affiliations

[1 ] Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Innsbruck, Austria.

[2 ] Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

[3 ] INNPATH, Institute of Pathology, University Hospital of Innsbruck, Innsbruck, Austria.

[4 ] Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Innsbruck, Austria herbert.tilg@i-med.ac.at.

Article

Publisher Item ID: gutjnl-2020-321375

DOI: 10.1136/gutjnl-2020-321375

PubMed ID: 32699098

SO-VID: efe06dd2-2479-4819-9732-bd7ad92365c6

History

Keywords: LIVER CIRRHOSIS,ALCOHOLIC LIVER DISEASE

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Keywords: LIVER CIRRHOSIS, ALCOHOLIC LIVER DISEASE

Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans.

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