- Record: found
- Abstract: found
- Article: not found
Treatment of HCV infection by targeting microRNA.
Harry L A Janssen
1 ,
Hendrik W Reesink ,
Eric J Lawitz ,
Stefan Zeuzem ,
Maribel Rodriguez-Torres ,
Keyur Patel ,
Adriaan J van der Meer ,
Amy K Patick ,
Alice Chen ,
Yi Zhou ,
Robert Persson ,
Barney D King ,
Sakari Kauppinen ,
Arthur A Levin ,
Michael R Hodges
May 02 2013
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The stability and propagation of hepatitis C virus (HCV) is dependent on a functional interaction between the HCV genome and liver-expressed microRNA-122 (miR-122). Miravirsen is a locked nucleic acid-modified DNA phosphorothioate antisense oligonucleotide that sequesters mature miR-122 in a highly stable heteroduplex, thereby inhibiting its function.