Information for ICRR2015

Abstract

1. List of invited speakers at ICRR2015 May 25, 2015 Plenary Lecture Shinya Yamanaka (Japan), Recent Progress in iPS Cell Research and Applications. Akito Arima (Japan), The Accident at the Fukushima Dai-ichi Nuclear Power Station, Radiation, and the Future of Energy in the World. May 26, 2015 Eye Opener Wolfgang Doerr (Austria), Radiobiology of Normal Tissue Effects in Radiation Oncology—Progress and Perspectives. Kotaro Ozasa (Japan), Epidemiological Research on Radiation-induced Cancer in Atomic Bomb Survivors. Seiichi Tagawa (Japan), The Cutting Edge of Radiation Chemistry: the Game Changer of Semiconductor Manufacturing. Kenshi Komatsu (Japan), Cloning of NBS1 and DNA Repair Genes: Strand Break Repair Is Linked to Cellular DNA Damage Responses. Nagara Tamaki (Japan), Tumor Hypoxia: A New PET Imaging Marker for Treatment Planning. Fumio Hanaoka (Japan), Forty Years of DNA Damage Tolerance. W Gillies McKenna (UK), High-throughput Screens for Targets to Modify Radiosensitivity. Robert Bristow (Canada), Translating Tumor Heterogeneity Analyses of Hypoxia and Genomics to Prostate Cancer Medicine. Congress Lecture Marco Durante (Germany and Italy), Charged Particles. Catherine Booth (UK), The Response of The Small Intestine To Radiation Damage. Werner Ruehm (Germany), Dose Rate Effects in Radiation Biology and Radiation Protection. James F. Wishart (USA), Recent Progress in Pulse Radiolysis. Keigo Endo (Japan), Targeted Radionuclide Therapy—Recent Advances and Information About The Health Effects of Radioactive Materials Released by The Nuclear Accident Ashok Venkitaraman (UK), Tumor Suppressor Mechanisms in The Control of Genome Stability and Radiation Responsiveness. Jan HJ Hoeijmakers (Netherlands), DNA Damage Repair and the Impact on Aging. Christopher H Crane (USA), The Role of Dose Escalation Using Hypofractionation, IMRT and IGRT in Patients with Locally Advanced Pancreatic Cancer. Jean Bourhis (Switzerland), Recent Advances in Radiation Therapy for Head and Neck Cancer. Fei Fei Liu (Canada), Complexity of Micro-RNAs in Human Cancers JRRS [Award Lecture] 2015 Yoshiya Shimada (Japan), Critical Age at Exposure and Underlying Biological Mechanisms for Radiation Carcinogenesis in Experimental Animal Models. Takako Yasuda (Japan), Efficient Elimination of Radiation-induced Apoptotic Cells by Microglia During Tissue Repair in the Developing Medaka Brain. Tokuhisa Hirouchi (Japan), Murine Myeloid Leukemia Induced by Chronic Exposure to Low-dose-rate Radiation Is Qualitatively Different from High-dose-rate Radiation–induced Myeloid Leukemia. Symposium: Tissue Stem Cells and Radiation Carcinogenesis Chairpersons: Mary Helen Barcellos-Hoff (USA), Tatsuhiko Imaoka (Japan) Jolyon H Hendry (UK), A New ICRP Report: Stem Cell Biology with Respect to Carcinogenesis—Aspects of Radiological Protection. Christian Streffer (Germany), Genomic Instability and Carcinogenesis and Consideration of Prenatal Radiation Exposures. Barry R Stripp (USA), Epithelial Progenitor Cells of the Conducting Airway and Their Response to Ionizing Radiation. Kensuke Otsuka (Japan), Radiation Response for Various Dose Rates on Intestinal Stem Cells. Mary Helen Barcellos-Hoff (USA), Dysregulation of Mammary Stem Cells in Response to Radiation Promotes Triple Negative Breast Cancer. Symposium: Radiation Response in Differentiated Cells and Non-cancer Disease Chairpersons: Seiji Kodama (Japan), Fiona Stewart (The Netherlands) Hiroshi Mitani (Japan), Radiation-induced Apoptosis and Testis–Ova in p53-deficient Fish Testis. Naoki Takemura (Japan), Innate Immune Responses in Radiation-induced Intestinal Injury. Jacqueline P Williams (USA), Factors Affecting Normal Tissue Responses: The Role of Age, Organ, Dose and Dose Rate in Development and Progression of Early and Late Effects. Charles Limoli (USA), From The Clinic to Space: Causes and Consequences of Radiation-induced Cognitive Dysfunction. Symposium: Environmental and Health Effects of the Fukushima Nuclear Accident: the Distribution and Environmental Effects of Radioactive Materials Chairpersons: Toshimitsu Homma (Japan), Wolfgang Weiss (Germany) Tsuyoshi Yaita (Japan), New Interpretation of Cs Sorption Behaviors on Clay Minerals in Fukushima by Multiple Utilization of the Quantum Beam. Toshimitsu Homma (Japan), Implications of Radiological Consequences From Contamination of the Environment Due to The Fukushima Daiichi Accident. Tomoko M Nakanishi (Japan), Agricultural Implications of the Fukushima Nuclear Accident. Tatsuo Aono (Japan), Effects of Marine Pollution from Radionuclides After the Fukushima Daiichi Nuclear Power Station Accident. Symposium: Environmental and Health Effects of the Fukushima Nuclear Accident: Dose Estimation and Health Risk Chairpersons: Makoto Akashi (Japan), Carl-Magnus Larsson (Australia) Keiichi Akahane (Japan), Dose Estimations to Fukushima Residents After the Fukushima Nuclear Power Plant Accident. Osamu Kurihara (Japan), Estimation of Internal Thyroid Doses to Fukushima Residents and Remaining Issues. Shinji Tokonami (Japan), Overview of the Radiation Exposure Situation in the Initial Phase of the Fukushima Nuclear Accident. Ryugo Hayano (Japan), Internal Radiation Exposures of Fukushima Children—The Risk Is Low, But The Anxiety Is Still High Carl-Magnus Larsson (Australia), Health Implications of Radiation Exposure From The 2011 Nuclear Accident in Japan: The UNSCEAR 2013 Report. Symposium: Long-term Epidemiological Studies of the A-bomb Survivors and Their Offspring: Past, Present and Future Chairpersons: Martha S. Linet (USA), Toshiteru Okubo (Japan) Dale L Preston (USA), ABCC/RERF Atomic Bomb Survivor Studies and the Evolution of Statistical Methods for Characterization of Radiation Health Effects. Kyoji Furukawa (Japan), Statistical Modeling Issues for Risk Estimation in the Low-Dose Range. Atsuko Sadakane (Japan), Cancer Risk of Those Who Were Exposed as Children. Waka Ohishi (Japan), Studies Utilizing Clinical Information and Other Research Materials Obtained From the AHS Participants. Misa Imaizumi (Japan), Studies of Thyroid Diseases among AHS Participants Eric J Grant (Japan), Cancer and Non-cancer Disease Mortality among the Offspring of A-bomb Survivors. Symposium: New Aspects of Biological Responses to Low-dose/Low-dose-rate 1.1.1.1 Radiation Chairpersons: Michael J. Atkinson (Germany), Jun-ichiro Komura (Japan) Anna Saran (Italy), Cardiovascular Effects of Low-dose/Low-dose-rate Radiation: New Insights From Mouse Models. Michael J Atkinson (Germany), The Non-coding Transcriptome Is a Key Regulator of the Response to Low-dose Radiation. Sarah Baatout (Belgium), Potential Risks From an Exposure of Germ Cells or Embryos to Ionizing Radiation: Recent Scientific Data. Tomohisa Hirobe (Japan), Effects of Low-dose Radiations on Mouse Embryonic Development and on Melanocyte Differentiation in the Epidermis and Hair Bulb. Satoshi Tanaka (Japan), Transgenerational Effects in Male Mice Exposed to Continuous Low-dose-rate Gamma-rays. Symposium: Radiation Chemistry and Science in the 21st Century Chairperson: Simon M. Pimblott (UK) Yoichi Yoshida (Japan), Attosecond and Femtosecond Pulse Radiolysis. Jai P Mittal (India), Radiation Chemistry and Some 21st Century Challenges. Gerard Baldacchino (France), OH Radical Distribution Revealed in Ionization Tracks of Heavy Ions at Elevated Temperature. Jay A LaVerne (USA), From a Cell to a Nuclear Reactor—Radiation Chemistry in the 21st Century. Maolin Zhai (China), Radiation-induced Synthesis and Characteristics of Metal Nanocomposites. Symposium: Pulse Radiolysis in the 21st Century Chairperson: Mehran Mostafavi (France) Jinfeng Yang (Japan), Ultrafast Electron Microscopy/Difffraction for Radiation Chemistry. Kenji Takahashi (Japan), Spectra and Solvation Dynamics of Excess Electron in Ionic Liquids. Yusa Muroya (Japan), Observation of Solvated Electrons at Elevated Temperatures Up to Supercritical Condition by the Newly Improved ps Pulse-probe System. Dipak K Palit (India), Investigation of The Dynamics of Hydrogen Bonds in the Solvation of Electrons, Anions and Proteins in Protic Solvents Using Ultrafast Electron Pulses. Takafumi Kondoh (Japan), Ultrafast Electron Transfer in Dodecane Studied by Femtosecond Pulse Radiolysis. Symposium: Molecular Imaging Using Radioisotopes in Clinical Oncology Chairpersons: Tsuneo Saga (Japan), Ursula Nestle (Germany) Ursula Nestle (Germany), Applications of Molecular Imaging in Radiation Oncology. Richard L Wahl (USA), Quantitative In Vivo Phenotyping of Cancer Using PET, SPECT Molecular Imaging and PERCIST 1.0 to Personalize Oncologic Therapies. Hiroaki Kurihara (Japan), 64Cu-DOTA-trastuzumab PET Imaging in HER2-positive Breast Cancer Patients. David J. Yang (USA), Hexosamine Pathway–directed Theranostic for Cancers. Tsuneo Saga (Japan), Molecular Imaging of Cancer Hypoxia and Development of Internal Radiotherapy Targeting Hypoxic Microenvironment. Symposium: Recent Advances in Targeted Radionuclide Therapy Chairpersons: Seigo Kinuya (Japan), Yaming Li (China) Seigo Kinuya (Japan), Toward Individualized Radionuclide Theranostics. Yaming Li (China), Application of PET/CT in China. Andreas K Buck (Germany), Recent Developments in Peptide Radioreceptor Therapy (PRRT) for Neuroendocrine Tumors: Improving Therapeutic Effectiveness, Reducing Toxicity. Makoto Hosono (Japan), Update and Prospects of Alpha-emitters in Targeted Radionuclide Therapy. Symposium: Pathways and Players in DNA Repair Chairpersons: John Rouse (UK), Shinichiro Nakada (Japan) Fabrizio d'Adda di Fagagna (Italy), The Role of Transcription in the Control of DNA Damage Response Modulation. John Rouse (UK), Dissecting the Roles and Regulation of DNA Repair Nucleases. Shinichiro Nakada (Japan), DNA Damage–induced Ubiquitination Affects DNA Repair Pathway Choice. Seth J. Field (USA), GOLPH3 Links The Golgi, DNA Damage, and Cancer. Symposium: Human Diversity Affecting Biological Responses to Radiation Chairpersons: Martin F. Lavin (Australia), Minoru Takata (Japan) Martin F. Lavin (Australia), Investigating Genetic Disorders to Understand Diversity of Radiation Response. Roger A. Greenberg (USA), Genetic Interactions Within the BRCA Tumor Suppressor Network. Qiang Pan Hammarstrom (Sweden), Hypomorphic Mutations in DNA Repair Genes are Associated with Human Primary Immunodeficiency. Kaoru Sugasawa (Japan), Molecular Mechanism of DNA Damage Recognition in Mammalian Nucleotide Excision Repair. Symposium: Non-ionizing Radiation and Risk for Human Health: Comparison of Ultraviolet Radiation and Ionizing Radiation Chairpersons: Todd Washington (USA), Takeshi Todo (Japan) Todd Washington (USA), Architecture and Dynamics of Protein Complexes Containing Proliferating Cell Nuclear Antigen. Hiroshi Hashimoto (Japan), Structure and Function of REV7 as the Adaptor Protein of REV1 and REV3 Polymerases. Yoshiki Murakumo (Japan), Suppression of REV7 Enhances Cisplatin Sensitivity in Ovarian Clear Cell Carcinoma Cells. Kei-ichi Takata (USA), The POLQ/ HELQ/ POLN Family in DNA Damage Tolerance. Symposium: Genetic and Epigenetic Mechanisms of Environmental Stress Chairpersons: YoungRok Seo (Korea), Akira Tachibana (Japan) Pei Hsin Chou (Taiwan), Characterization of Contaminants in Sewage Wastewater Using Biological Assays and Liquid Chromatography Tandem Mass Spectrometry. Young Rok Seo (Korea), A Novel Mechanism for Heavy Metal–induced Mutagenicity and Carcinogenicity via Integrative Approaches Using Molecular Toxicology and Toxicogenomics in an In Vivo System. Yuko Ibuki (Japan), Histone Modifications Induced by Chemicals and Change of Sensitivity to UV. Masanobu Kawanishi (Japan), Adduct Formation and Repair, and TLS across The Adducts in Human Cells Exposed to the Environmental Carcinogen 3-nitrobenzanthrone. Symposium: Combination of Molecular Targeting Agents and Radiation Chairpersons: Yoshihiro Takai (Japan), George Iliakis (Germany) Tetsuo Akimoto (Japan), Clinical Perspective of Combined Molecular Targeting Agents and Radiation Therapy. Kazushige Hayakawa (Japan), Combined Use of Molecular Targeting Drugs in Radiation Therapy for Locally Advanced Non–Small Cell Lung Cancer. George Iliakis (Germany), Inhibition of Homologous Recombination and Promotion of Mutagenic Repair of DNA Double-strand Breaks Underpins araA Radiosensitization. In Ah Kim (Korea), Targeting Prosurvival Signaling implicated in Radiation Response: Translation into Clinic. Hong Gyun Wu (Korea), Epidermal Growth Factor As a Potential Anti-cancer Agent and Radiosensitizer. Symposium: Radiation Oncology Update: Breast Cancer Chairpersons: Bruce G. Haffty (USA), Philip M.P. Poortmans (The Netherlands) Philip M.P. Poortmans (The Netherlands), What's Hot for Radiation Therapy in Breast Cancer in Europe? Helen H.W. Chen (Taiwan), Clinical Outcome, Prognosis and Tumor Characteristics of Breast Cancer with Brain Metastases Receiving Radiation Therapy. Bruce G Haffty (USA), Hot Topics for Breast Cancer in The USA. Naoto Shikama (Japan), Update of Radiotherapy for Breast Cancer in Japan. Silvia C Formenti (USA), Prone Accelerated Whole Breast Radiotherapy with a Daily Versus Weekly Boost to the Tumor Bed: Results for 800 Patients. Symposium: Dose Rate Effect in Brachytherapy Chairpersons: Michael C. Joiner (USA), Jun Itami (Japan) Michael C. Joiner (USA), Radiobiology Meets Physics in Brachytherapy. Atsunori Yorozu (Japan), LDR Prostate Brachytherapy—Permanent Prostate Brachytherapy Yasuo Yoshioka (Japan), Extremely Hypofractionated Radiotherapy for Prostate Cancer Using High-dose-rate Brachytherapy as Monotherapy. Tomoaki Tamaki (Japan), Dose Rate in Brachytherapy for Cervical Cancer. Junjie Wang (China), An Experimental Modal Investigation of The Dosimetry Parameters for the Self-expandable Esophageal Stent Loaded with 125i Seeds. Symposium: Predictive Assays for Radiotherapy: Biomarkers for Strategies for Selection of Radiotherapy and/or Radiotherapy-sensitive Phenotype Chairpersons: Christian Nicolaj Andreassen (Denmark), Yoko Harima (Japan) Christian Nicolaj Andreassen (Denmark), Tailoring of Radiotherapy Using Genetics—Recent Progress, Perspectives and Obstacles. Takashi Imai (Japan), Individual Sensitivity to Clinical Radiotherapy: Assessing Interactions among SNPs of Genes of the Radiation Response Pathways. Yoko Harima (Japan), Serum ApoC-II and MMP-1 as Biomarkers to Predict Outcome of Chemoradiation Therapy in Patients with Cervical Cancer. Kai Rothkamm (Germany), Can Functional Biomarkers of DNA Damage and Repair Predict the Individual Radiation Response? Jinsil Seong (Korea), Serum Interleukin-6 as a Prognosis Predictor in Patients Treated with Radiotherapy for Hepatocellular Carcinoma. Wednesday, May 27 Eye Opener Zhimin Yuan (USA), Low-dose Radiation Induces an Adaptive and Protective Metabolic Response. Andrzej Wojcik (Sweden), Biological Dosimetry in Large-scale Accidents. Mohamad I AlSheikhly (USA), An Eye Opener on the Bright Future of Radiation Chemistry and Radiation Processing, and Non-power Nuclear Applications. Kaori Togashi (Japan), Functional MR Imaging in Gynecologic Field. Shunichi Takeda (Japan), Genetic Analysis of Proteins Involved in The Initial Step of Double-strand Break Repair. Samuel H. Wilson (USA), Radiation-induced Effects Compromise the DNA Polymerase and Ligation Steps in DNA Repair. Boguslaw A Maciejewski (Poland), Overall Treatment Time in Fractionated Radiotherapy. Congress Lecture Ignacia Tanaka (Japan), Neoplasia in Mice Chronically Exposed to Very Low Dose-rates of Gamma-rays. Shunichi Yamashita (Japan), Lessons Learned from Radiation Health Risk Management around Chernobyl and in Fukushima. Gayle E Woloschak (USA), Molecular Responses to Low-Dose and Low-dose-rate Radiation. Mehran Mostafavi (France), Ultrafast Oxidation Reaction Induced by Radical Cation H22O+. Kazuhiro Katada (Japan), Development and Current Status of Area Detector CT. Markus Lobrich (Germany), Repair of DNA Double-strand Breaks by Homologous Recombination. Robert P Fuchs (France), An Integrated View of Induced Mutagenesis. Avraham Eisbruch (USA), IMRT for HN Cancer: Emphasis on Reducing Xerostomia and Dysphagia. Ritsuko Komaki (USA), Recent Advances in Radiation Therapy for Lung Cancer. Richard P Hill (Canada), Update on Cancer Stem Cells and Radioresistance. ICRR Special Lecture Kenji Kamiya (Japan), Health Effects of the Fukushima Nuclear Accident and Research on Low-dose Radiation. [Award Lecture]: LH Gray Medal (Gray Award) by ICRU Fiona Stewart (Netherlands), Mechanisms of Development of Cardiovascular Disease in Irradiated Cancer Patients and the Possible Influence of ErbB2 Blocking Agents. ERRS YIA Session Grainne Manning (UK), Tissue Specificity of Long-term mRNA and miRNA Expression after X-ray Exposure in Mouse Strains with Different Susceptibility to rAMI. Mieke Verslegers (Belgium), In vivo Characterization of Cell-specific DNA Damage, Cell Death and Cell Cycle Kinetics in the Prenatally Irradiated Mouse Brain. Johanna Mirsch (Germany), Dose Delivered by δ-electrons of High-LET Radiation Decreases with the Square of the Distance to the Ion Trajectory. Anne Graupner (Norway), Genotoxic Effects of Continuous Chronic Low-dose-rate Gamma Irradiation and Se Deficiency. Ravi S Narayan (Netherlands), Targeting The MAPK Pathway by MEK162 Sensitizes Glioma Spheroids to Radiotherapy. Ronja DiemerBiehs (Germany), A Canonical End-joining Pathway in G1-phase Involves a CtIP- and Artemis-dependent Resection. Monika A. Frenzel (France), Telomere Status a Long Time after Radiotherapy—a Low Dose Study on a French Haemangioma Cohort. Giorgio Baiocco (Italy), A Comprehensive Modeling Approach to Shedding Light on the Physical Origin of Neutron Biological Effectiveness. Symposium: Normal Tissue Response to Low-dose/Low-dose-rate Irradiation Chairpersons: Michele Martin (France), Keiji Suzuki (Japan) Claudia E. Ruebe (Germany), DNA Damage Accumulation in Normal Tissues after Very Low Doses of Ionizing Radiation. Michele T Martin (France), Dissecting Radiation Effects on Progenitors and Stem Cells from Human Skin. Keiji Suzuki (Japan), DNA Damage Response and Tissue Reaction in Mouse Tissues/Organs Exposed to Low-dose/Low-dose-rate Radiation. Tatsuhiko Imaoka (Japan), Response of the Normal Mammary Epithelium to Radiation and Its Relevance to Carcinogenesis. Symposium: Omics Approach to Low-dose/Low-dose-rate Radiation Studies Chairpersons: Sally A. Amundson (USA), Tetsuya Ono (Japan) Andrew J Wyrobek (USA), Simulated Space Radiation Induces Changes in CNS Proteomes Associated with Deficits in Neurocognitive Performance. Soile Tapio (Germany), The Effect of Low-dose-rate Irradiation on the Brain, Heart and Liver Proteome of ApoE (-/-) Mice. Keiji Ogura (Japan), Analysis of Transgenerational Effects on DNA Copy Number Aberrations Using Oligo-microarray CGH in Male Mice Exposed to Continuous Low-dose-rate Gamma-rays. Naohiro Tsuyama (Japan), Low-dose Radiation Metabolomics in Human Cells. Symposium: Environmental and Health Effects of the Fukushima Nuclear Accident Chairpersons: Shunichi Yamashita (Japan), Kenji Kamiya (Japan) Makoto Akashi (Japan), Lessons Learned from the Accident at the Fukushima Daiichi Nuclear Power Plant: From the Viewpoint of Radiation Emergency Medicine. Koichi Tanigawa (Japan), Emergency Medical Responses in the Fukushima Accident. Akira Ohtsuru (Japan), Thyroid Ultrasonography Screening after the Fukushima Nuclear Power Plant Accident: a Fukushima Health Management Survey. Masaharu Maeda (Japan), Psychosocial Consequences of Fukushima Disaster. Seiji Yasumura (Japan), Health Status Found in the Fukushima Health Management Survey and Countermeasures. Symposium: Lessons Learned in Health and Medical Aspects: From A-bomb and Chernobyl to Fukushima Chairpersons: Yuji Nagayama (Japan), Christoph Reiners (Germany) Kazunori Kodama (Japan), Lessons Learned from the Long-term Epidemiological Studies of the Atomic Bomb Survivors. Dimitry Bazyka (Ukraine), Health Effects and Biological Markers of Radiation Exposure in Cleanup Workers at the Chernobyl Accident. Mykola D Tronko (Ukraine), Results and Prospects of Long-Term Monitoring of Ukrainian–American Thyroid Cohort. Jacques Jean Lochard (France), Radiation Monitoring and Health Surveillance in the Service of Improving Living Conditions in Post-accident Situations: Some Lessons from Chernobyl. Noboru Takamura (Japan), Crisis and Risk Communications in Fukushima Based on Experience Gained at Nagasaki and Chernobyl. Tatsuo Ichinohe (Japan), Recent Advancements in Stem Cell Transplantation for Casualties of Nuclear Disasters. Symposium: DoReMi—Low-dose Research towards Multidisciplinary Integration —ICRR Symposia Introduction to the European DoReMi Programme of Low-dose Risk Research from DoReMi to CONCERT: Next Steps in European Radiation Protection Research Chairpersons: Sisko Salomaa (Finland), Laure M. Sabatier (France) Sisko Salomaa (Finland), Introduction to the European DoReMi Programme of Low-dose Risk Research. Andrea Ottolenghi (Italy), Education and Training Actions. Laure M Sabatier (France), Infrastructures. Udo S Gaipl (Germany), Impact of Ionizing Radiation on Inflammation and Carcinogenesis. Dik C van Gent (Netherlands), Linear and Non-linear Dose–Effect Relationships of Low-dose Ionizing Radiation. Christophe M Badie (UK), Integrated Systems Level Analysis of Myeloid Leukemogenesis and Evaluation of the Molecular Alterations of Antigenic T-cell Receptor Repertoire Following X-irradiation. Siamak Haghdoost (Sweden), Mechanism Underlying Individual Radiosensitivity of Breast and Head and Neck Cancer Patients. Jean-Rene Jourdain (France), Non-cancer Effects Resulting from Low-dose Exposure to Ionizing Radiation: Main Achievements of the DoReMi European Network of Excellence. Symposium: New Perspectives in Epidemiological Studies of Low-dose Exposure and Cancer Risk Chairpersons: Kotaro Ozasa (Japan), Kiyohiko Mabuchi (Japan) Amy Berrington (USA), Diagnostic Radiation and Cancer Risks. Martha S Linet (USA), Cancer Risks in Medical Radiation Workers. Ausrele Z Kesminiene (France), Cancer Following The Chernobyl Nuclear Plant Accident. Steven L Simon (USA), Advances in Radiation Dosimetry for Health Risk Studies. Stephen J Chanock (USA), Genetic Susceptibility and Cancer. Symposium: Innovative Processes and Materials Produced by Radiation Chairpersons: Dipak P. Palit (India), Hideki Namba (Japan) Olgun Guven (Turkey), Controlling of Radiation-induced Free Radical Homo- and Block Copolymerization of N-Vinyl Pyrrolidone and t-Butyl Acrylate by the RAFT Technique. Dianne Poster (USA), Radiation Chemistry Activities at NIST to Support the Synthesis of Magnetic Nanocomposites. Masakazu Washio (Japan), Recent Progress in Quantum Beam Technology. Guozhong Wu (China), The Use of Radiation-degraded Chitosan as an Alternative to Antibiotics for Animal Feed Additive. Hakaru Mizoguchi (Japan), Performance of a 100 Watt HVM LPP-EUV Source for Microlithograpy Applications. Symposium: New Prospects for Radiation Science and Nanotechnology, Electron Collisions with Matter, and Positronium Chairpersons: Asokendu Mozumder (USA), Tetsuya Hirade (Japan) Tetsuya Hirade (Japan), Positronium in Room Temperature Ionic Liquids. Masayasu Takeda (Japan), Neutron Reflectometry as a Non-destructive Tool to Analyze Buried Interfaces in Layered Thin Films. Yasuyuki Nagashima (Japan), Studies on the Positronium Negative Ion. Asokendu Mozumder (USA), Time Scales and Processes for Electron Thermalization in Liquid Water at Room and Higher Temperatures. Masashi Kitajima (Japan), Ultra-low-energy Electron Collision Cross-sections of Atoms and Molecules. Symposium: Radiation Dose Management on CT Chairpersons: Yoshinori Funama (Japan), Katsuyuki Taguchi (USA) Satoshi Tashiro (Japan), Biological Estimation of the DNA Damage Induced by a CT Scan. Takeshi Nakaura (Japan), Clinical Impact of the Iterative Reconstruction (Hybrid-IR and Full-IR) for Low-dose CT of Head and Abdomen. Kakuya Kitagawa (Japan), Radiation Dose Management in Cardiac CT. Yutaka Tanami (Japan), Radiation Dose Management of CT in Pediatrics. Katsuyuki Taguchi (USA), Photon-counting Low-dose CT: Imaging Methods. Symposium: Functional Imaging Using CT Chairpersons: Yeon Hyeon Choe (Korea), Kazuo Awai (Japan) Hiroshi Moriya (Japan), Quantification of Regional Lung Parenchyma Movement Using Dynamic Respiratory CT. Yoshiharu Ohno (Japan), Basics and Clinical Applications for Body Functional CT. Yuko Nakamura (Japan), Hepatic Perfusion CT: Current Status and Future Perspectives. Yeon Hyeon Choe (Korea), Functional Imaging Using CT. Symposium: Dynamics of Chromatin and Nuclear Architecture in Radiation-damaged Cells Chairpersons: Gisela Taucher Scholz (Germany), Kanji Furuya (Japan) Kanji Furuya (Japan), Mitotic Kinase-dependent Phosphorylation of DNA Damage Checkpoint Proteins. Gisela Taucher Scholz (Germany), Spatiotemporal Protein Dynamics and Double-strand Break Repair: the Impact of Damage and Chromatin Complexity. Tsuyoshi Ikura (Japan), The Role of Histone H2AX Dynamics in the DNA Damage Response. Xuetong Shen (USA), Regulation of Key Checkpoint Kinases by ATP-dependent Chromatin Remodeling Complexes. Symposium: The radiation-induced DNA Damage Response and Cell Death Chairpersons: David J. Chen (USA), Hiroshi Tauchi (Japan) Penelope A Jeggo (UK), Radiation-induced DNA Damage and Cell Death in the Embryonic and Adult Brain. Mendonca Marc S (USA), Alteration of Warburg Metabolism and NF-kB Signaling to Enhance Pancreatic Cancer X-ray Sensitivity. Prakash M Hande (Singapore), Disruption of Telomere Equilibrium Sensitizes Human Cancer Cells to DNA Repair Inhibition and Radiation. David J. Chen (USA), Phosphorylation of Ku Results in Displacement from DNA Ends, Which Plays a Role in DNA Double-strand Break Repair Pathway Choice. Symposium: Processing of Oxidized DNA Damage Chairpersons: Samuel Wilson (USA), Akira Yasui (Japan) Susan S Wallace (USA), How Do DNA Glycosylases Locate Radiation-damaged DNA Bases? Li Lan (USA), A Novel Method for Site-specific Induction of Oxidative DNA Damage at Specific Genome Loci. Miral Dizdaroglu (USA), Inhibition of DNA Glycosylases via Small Molecule Compounds as Potential Therapeutic Drugs. Yusaku Nakabeppu (Japan), MUTYH-dependent Programmed Cell Death Triggered by 8-oxoguanine and its Implication in Tumor Suppression and Neurodegeneration. Thomas Helleday (Sweden), MTH1 Inhibition Eradicates Cancer by Preventing Sanitation of the dNTP Pool. Symposium: Combined Exposure of Ionizing Radiation and Chemicals Chairpersons: Shizuko Kakinuma (Japan), Michaela Kreuzer (Germany) Michaela Kreuzer (Germany), Mortality Associated with Exposure to Radon Progeny and Silica Dust—Results of the German Uranium Miner Cohort Stud. Kyoji Furukawa (Japan), Radiation-associated Cancer Risks by Smoking History: Epidemiological Findings in the Life Span Study. Yutaka Yamada (Japan), The Combined Effects of X-rays and N-nitrosobis (2-hydroxypropyl) Amine on Lung Carcinogenesis in Neonatal, Juvenile and Adult Wistar Rats. Shizuko Kakinuma (Japan), The Molecular Mechanisms Underlying The Induction of T-cell Lymphomas by Combined Exposure to Ionizing Radiation and a Chemical Carcinogen in B6C3F1 Mice. Symposium: (Prof. Withers’ Memorial Symposium) Dose Fractionation: From Hyperfractionation to Hypofractionation Chairpersons: Yuta Shibamoto (Japan), Soren M Bentzen (USA) Soren M Bentzen (USA), Prof. Withers’ Memorial Address. Koichi Ando (Japan), Prof. Withers’ Memorial Address. Michael C Joiner (USA), New Radiobiology for Hypofractionation: It's No Longer Just LQ. Soren M. Bentzen (USA), Evidence-base for Hypofractionation in Curative Radiotherapy: Lessons from the Randomized Controlled Trials. Yuta Shibamoto (Japan), Radiobiological Assessment of Hypofractionated Radiation Doses Employed in Stereotactic Radiotherapy: Recommendation on Optimal Fractionation Schedules. Katsumasa Nakamura (Japan), Hypofractionated Radiotherapy for Prostate Cancer. Leszek Miszczyk (Poland), Split-course Accelerated Hyperfractionation for Advanced Head and Neck Cancer —Results of Randomized Trial. Symposium: Radiation Oncology Update: Chemoradiotherapy Chairpersons: Hak Choy (USA), K. Nemoto (Japan) Hak Choy (USA), Radiation Oncology Update: Chemoradiotherapy for Lung Cancer. Rainer J. Fietkau (Germany), Chemoradiotherapy. Keiichi Jingu (Japan), Update of Chemoradiotherapy for Esophageal Cancer. Takafumi Toita (Japan), Chemoradiotherapy for Uterine Cervical Cancer. Yexiong Li (China), Risk-adapted Therapy for Early-stage NK/T-Cell Lymphoma. Symposium: Educational Seminar: Radiobiology Updates for Radiation Oncologists Chairpersons: Eric J. Bernhard (USA), Norio Mitsuhashi (Japan) Marie Catherine Vozenin (Switzerland), Role of HPV Status on Radiotherapy Outcome. Bradly G Wouters (Canada), The Importance of Hypoxia in Radiation Oncology—Past, Present and Future. Elizabeth L Travis (USA), Radiation Injuries to the Lung: What's New. Marc Vooijs (Netherlands), Targeting the Notch Pathway in Cancer. Ryuichi Okayasu (Japan), Radiobiology Updates for Radiation Oncologists. Eric J Bernhard (USA), Future Developments in Radiation Oncology and Biology: Promises and Issues from a Granting Agency Perspective. Symposium: Radiosensitization in Clinical Oncology Chairpersons: Martin J. Brown (USA), Keisuke Sasai (Japan) Keisuke Sasai (Japan), Radiosensitizers from the Viewpoint of a Radiation Oncologist. Martin Brown (USA), Tumor-associated Macrophages Govern the Response of Solid Tumors to Radiotherapy. Kazuhito Tanabe (Japan), Expression of Drug Potency Upon X-irradiation: Characteristics of a Drug-encapsulating Aggregate of Amphiphiles Possessing the Disulfide Bond. Masanori Someya (Japan), Radiosensitization with Gimeracil and Olaparib. Yasuhiro Ogawa (Japan), Safety and Effectiveness of a New Enzyme-targeting Radiosensitization Treatment (KORTUC II) for Intratumoral Injection for Low-LET Radioresistant Tumors. Thursday, May 28 Eye Opener Hiroshi Tanooka (Japan), Dose-rate Effects in Radiation Carcinogenesis: a Look from Hiroshima/Nagasaki to Fukushima. Takashi Nakano (Japan), Current Status of Carbon Ion Therapy for Cancers. Michael D Sevilla (USA), Free Radical Mechanisms of Radiation Damage to DNA. Junichi Hiratsuka (Japan), The Principle and History of Neutron Capture Therapy. Satoshi Tashiro (Japan), Nuclear Topography of Homologous Recombinational Repair. Takeo Ohnishi (Japan), Life Science Experiments Performed in Space in the ISS/Kibo Facility and Future Plans. Kathryn A Higley (USA), Impact of Ionizing Radiation on Environmental Biota. Dirk LJ Verellen (Belgium), Eye Opener: Progress of RT for Moving Targets. Chang W Song (USA), Tumor Microvasculature as a Target of Therapy. Congress Lecture Ryo Kominami (Japan), Cell of Origin in Radiation-induced Premalignant Thymocytes. Arnab Chakravarti (USA), Novel Personalized Care Strategies for Prostate Cancer and Glioma Patients. Mark H Whitnall (USA), Armed Forces Radiobiology Research Institute Program: Accomplishments, Opportunities and Policy Questions. Yosuke Katsumura (Japan), Radiation Chemistry in the Nuclear Accident after the Fukushima Accident. Koji Ono (Japan), The Current State and Future Prospects of BNCT. Alexander Spektor (USA), DNA Damage in Micronuclei Generates Chromothripsis and Other Complex Chromosomal Rearrangements. Francis A Cucinotta (USA), Track Structure Effects in Galactic Cosmic Ray–induced Cancer and Central Nervous System Risks. Deborah A Kuban (USA), Recent Advances in Radiation Therapy for Prostate Cancer. Michael R Horsman (Denmark), The Impact of Hypoxia and Its Modification on The Outcome of Radiotherapy. ICRR Special Lecture Masahiro Hiraoka (Japan), The Evolution of Radiation Therapy: from 3D to 4DRT. JRRS Special Session; JRRS President Lecture Manabu Fukumoto (Japan), Attracted to Radiation Biology: From Thorotrast to The Future. [Award Lecture]: The Weiss Medal (Weiss Medal) by ARR Ian J Stratford (UK), Hypoxia and Tumour Cell Radiosensitivity. Symposium: Molecular Mechanisms of Radiation Carcinogenesis in Animal Models Chairpersons: David G. Kirsch (USA), Yoshiya Shimada (Japan) Yoshiya Shimada (Japan), Modification of Radiation-related Molecular Signatures by Age at Exposure in Murine Tumors. Kazuhiro Daino (Japan), Aberrant DNA Methylation in Radiation-induced Rat Mammary Carcinogenesis. David G Kirsch (USA), An Extra Copy of p53 Suppresses Initiation of Kras-driven but Not Radiation-induced Tumors. Tomonori Hayashi (Japan), Radiation Effects Studies on Intracellular ROS Levels in Atomic-bomb Survivors and Mice. Symposium: Hiroshima University RIRBM Joint Usage/Research Center Symposium: Molecular Mechanisms of Radiation-induced Cancer Chairpersons: Masao Tomonaga (Japan), Toshiya Inaba (Japan) Jiri Bartek (Denmark), Cellular Response to DNA Double-strand Breaks: Mechanisms and Relevance to Cancer Development and Treatment. Grigory L Dianov (UK), DNA Damage Recognition, Signaling and Repair in Response to Ionizing Radiation. Masako Iwanaga (Japan), Epidemiology of Radiation-induced Hematopoietic Malignancies. Hirotaka Matsui (Japan), Hematological Malignancies Harboring Monosomy 7 as Secondary Diseases in Irradiated Patients. Vladimir A Saenko (Japan), Gene Rearrangements in Radiation-induced Thyroid Cancer. Symposium: Topics in Physics and Biology for Particle Therapy Chairpersons: Kathryn Held (USA), Tatsuaki Kanai (Japan) Kathryn D Held (USA), Biological Effectiveness of Charged Particles in Tumor Cells. Séverine Rossomme (Belgium), Reference Dosimetry for Carbon Ion Beams Based on Calorimetry. Koichi Ando (Japan), Relations between DNA Repair, Cellular Repair, Survival Parameters and RBE of High-LET Radiation. Toshiyuki Shirai (Japan), Treatment of Moving Targets with Scanned Ion Beams. Symposium: Clinical Research on Particle Therapy; Strategies for Advanced Particle Therapy Chairpersons: Tadashi Kamada (Japan), Thomas F DeLaney (USA) James D Cox (USA), Clinical Research on Particle Therapy; Example of Lung Cancer Proton Therapy Interacting with Chemotherapy for Locally Advanced Non–Small Cell Lung Cancer. Thomas F DeLaney (USA), Current Status of Clinical Proton Radiation Therapy. Hiroshi Tsuji (Japan), Progress of Carbon Ion Cancer Therapy in Japan. Hideyuki Sakurai (Japan), Proton Beam Therapy in Japan. Symposium: Current Situation and Issues of Dose Assessment for Natural Radiation Exposure: Special Expenditures Project of Ministry of Education, Culture, Sports, Science and Technology; Advanced Human Resources Development Project for Radiation Emergency Medicine Chairpersons: Shinji Tokonami (Japan), Ikuo Kashiwakura (Japan) Atsuyuki Sorimachi (Japan), Dosimetry and Dose Evaluation for Inhalation of Radon and Thoron in High Background Radiation Areas. Suminori Akiba (Japan), Epidemiological Studies in High Background Radiation Areas. Gerald M Kendall (UK), Childhood Cancer and Natural Ionizing Radiation: Published Results and Future Prospects. Saidou O (Cameroon), Natural Radiation Survey in the Uranium- and Thorium-bearing Regions of Cameroon. Dadong Iskandar (Indonesia), Environmental Radiation and Radioactivity Levels in Mamuju Regency as One of the High Natural Radiation Areas in Indonesia Dadong Iskandar, Bunawas, Syarbaini, Eko Pudjadi, Kusdiana and Wahyudi. Symposium: Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster Protection and Prospects in Radiation Disasters Chairpersons: Kenji Kamiya (Japan), Jacques Lochard (France) Jacques Jean Lochard (France), The Updating of ICRP Publication 111 in Light of the Fukushima Experience Feedback. Deborah H Oughton (Norway), Ethical Aspects of Radiation Protection. Michiaki Kai (Japan), New Insights into Radiological Protection with Recovery Management from the Fukushima Accident. Nobuhiko Ban (Japan), Challenges for the Science Community after Experiencing the Fukushima Nuclear Accident. Reiko Kanda (Japan), Risk Communication in the Event of a Radiation Disaster. Symposium: Progress in Radiation Chemistry and Dosimetry in Biological Materials Chairpersons: Michael D Sevilla (USA), Shin-ichiro Hayashi (Japan) Jean Cadet (Canada), Radiation-induced Damage to Cytosine and 5-methylcytosine in Cellular DNA: Final Oxidation Products and Mechanistic Insights. Tetsuro Majima (Japan), Excess Electron Transfer in DNA. Yves De Deene (Australia), Safeguarding Radiotherapy: Measuring Dose Distributions in Three Dimensions. Chengshie Wuu (USA), Clinical Applications of 3-D Dosimeters. Alessia Gasparini (Netherlands), Visualizing Radiation: 3D Dose Distributions from Radio-fluorogenic Gels. Symposium: Radiation and Radiochemistry in Nuclear Research and Nuclear Accidents Chairpersons: James F. Wishart (USA), Yosuke Katsumura (Japan) Simon M Pimblott (UK), Investigation into the Radiolysis of Purex Solvent Systems. Jing Peng (China), Radiation Chemistry of Ionic Liquid-based Extraction Systems Used for Advanced Nuclear-fuel Reprocessing. Mats Jonsson (Sweden), Radiation-induced Corrosion of Copper Canisters Used in Geological Repositories for Spent Nuclear Fuel. Noriaki Seko (Japan), Removal of Radioactive Cesium from the Contaminated Water by Radiation-grafted Fabrics. Atsushi Tanaka (Japan), Breeding and Evaluation of Radiocesium Uptake Ability in Higher Plants by Quantum Beam Technology. Symposium: Clinical Study of BNCT Chairpersons: Shin-ichi Miyatake (Japan), Leena MK Kankaanranta (Finland) Jun Hatazawa (Japan), Positron Emission Tomography in Boron Neutron Capture Therapy. Minoru Suzuki (Japan), Boron Neutron Capture Therapy (BNCT) for Malignant Thoracic Tumors. Leena MK Kankaanranta (Finland), Boron Neutron Capture Therapy in the Treatment of Cancer. Ling Wei Wang (Taiwan), BNCT for Locally Recurrent Head and Neck Cancer at THOR: Possible Ways of Improving Our Clinical Results. Shinji Kawabata (Japan), Boron Neutron Capture Therapy for Brain Tumors. Symposium: Boron Delivery to Tumors Chairpersons: Mandy Schwint (Argentina), Mitsunori Kirihata (Japan) Amanda E Schwint (Argentina), Research Oriented Towards Optimizing the Efficacy of BNCT: Radiobiological Studies in Models of Oral Cancer and Liver Metastases. Rolf F Barth (USA), Boron Compounds and Their Delivery for Neutron Capture Therapy of Brain Tumors and Head and Neck Cancer. Hiroyuki Nakamura (Japan), Development of Liposomes for Efficient Boron Neutron Capture Therapy. FongIn Chou (Taiwan), Boric Acid–mediated Boron Neutron Capture Therapy for Treating Hepatoma: Boron Delivery and Selective Retention in Tumor and Tumor Vessels. Hideki Matsui (Japan), Development of the New Boron Agent, BSH-peptide: Towards Clinical Applications. Symposium: Frontiers of Radiation Research Chairpersons: Xuetong Shen (USA), Kiyoshi Miyagawa (Japan) Insa S Schroeder (Germany), Differentiation of Human Embryonic Stem Cells—Assessing the Risk of Radiation during Early Embryo Development. Benjamin J Blyth (Japan), Discovering the Role of Pten in Protecting from Tumours Induced by Childhood Irradiation. Michael Hausmann (Germany), Changes of Nucleosomal Arrangements after Irradiation and during Repair as Detected by Super-resolution Localization Microscopy. Lihua Zeng (China), Aberrant IDH3a Expression Promotes Malignant Tumor Growth by Inducing HIF-1–mediated Metabolic Reprogramming and Angiogenesis. Roger F Martin (Australia), New DNA-binding Antioxidants as Topical Radioprotectors. George DD Jones (UK), Redox Modulation of ROS-mediated Mechanisms: a Radical Therapeutic Approach for the Selective Targeting of Cancer Cells. Symposium: Re-evaluation of Biological Targets of Radiation-induced Cell Killing Chairpersons: Yuichiro Yokota (Japan), Ryoichi Hirayama (Japan) Dudley T Goodhead (UK), Targeted and Non-targeted Effects of Radiation. Munetoshi Maeda (Japan), Modification of Cell Death by Irradiation to the Cytoplasm. Dietrich WM Walsh (Germany), Carbon Ion–induced Mitochondrial Depolarization. Narongchai Autsavapromporn (Thailand), Genetic Changes in Progeny of Bystander Human Fibroblasts After Microbeam Irradiation with X Rays, Protons or Carbon Ions: the Relevance to Cancer Risk. Kohei Sasaki (Japan), Stochastic Modeling of Intercellular Signaling for Estimating DNA Damage with Confluent Cell Monolayers. Symposium: Early and Late Biological Effects of Space Radiation Chairpersons: Amy Kronenberg (USA), Masao Suzuki (Japan) Amy Kronenberg (USA), Charged Particle-induced Autosomal Mutagenesis: Mechanistic Analyses and Their Use in Risk Assessment for Cancer. Peter O'Neill (UK), DNA Damage and Repair after High LET Radiation—Early Effects Contribute to Late Consequences? Megumi Hada (USA), Induction of Chromosome Aberrations in Human Fibroblasts and Lymphocytes Exposed to Very Low Doses of High-LET Radiation. Qing Ye Sun (China), Effects of Microgravity on the DNA Damage Response in Caenorhabditis elegans during Shenzhou-8 Spaceflight. Eleanor A Blakely (USA), Harderian Gland Tumorigenesis: Low-dose- and LET response. M Kerry O'Banion (USA), HZE Exacerbates Alzheimer's Disease Pathology in Transgenic Mouse Models. Symposium: Physical Dosimetry for Space Radiation Chairpersons: Marco Durante (Germany), Yukio Uchihori (Japan) Guenther F Reitz (Germany), Assessment of Doses in the Environment and the Human Body On Board the International Space Station. Vyacheslav A Shurshakov (Russian Federation), Dose Distributions in a Human Body On Board the ISS as Obtained with the Tissue-Equivalent Spherical Phantom. Aiko Nagamatsu (Japan), Space Radiation Dosimetry in the ISS: Spearheading the Following Steps on the Pathway to Human Space Exploration Beyond Low-earth Orbit. Livio Narici (Italy), Radiation Measurement in the International Space Station with the ALTEA Detector System. Cary J Zeitlin (USA), Results from the RAD Experiment on the Curiosity Mars Rover. Chiara La Tessa (USA), Fragmentation of 3He and 4He in Elemental and Composite Target Materials. Symposium: the Advanced IGRT System for Motion Control Chairpersons: Per Poulsen (Denmark), Hiroki Shirato (Japan) Yukinori Matsuo (Japan), Dynamic Tumor Tracking Radiotherapy Using the VERO System for Realtime Motion Adaptation. Hiroki Shirato (Japan), Real-time-image Gated Proton Beam Therapy (RGPT) for Large Target Volumes in Motion: Development and Early Clinical Experiences. Per R Poulsen (Denmark), Multi-leaf Collimator Tracking in Radiotherapy. Jan JW Lagendijk (Netherlands), MRI-guided Radiotherapy: On-line MRI for Treatment Guidance. Eric F Lartigau (France), The advanced IGRT System for Motion Control in Robotic Extracranial Stereotactic Radiotherapy. Symposium: Radiation Therapy in the Era of IMRT Chairpersons: Arno J Mundt (USA), Kazuo Hatano (Japan) Nuria Jornet (Spain), Quality Management in IMRT. Junlin YI (China), The Role of Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma in the Era of Intensity-modulated Radiotherapy. Takashi Mizowaki (Japan), Intensity-modulated Radiation Therapy for Prostate Cancer: Current Status and Perspectives in Japan. Arno J Mundt (USA), Intensity-modulated Radiation Therapy in the Treatment of Gynecologic Cancers. Takeshi Kodaira (Japan), Definitive IMRT for Head and Neck Cancer Patients: Current Japanese Status and Perspectives. Symposium: International Symposium of Tumor Control by Radiation: Biology of Stereotactic Irradiation Chairpersons: David Brenner (USA), Masatoshi Hasegawa (Japan) David J Carlson (USA), Are More than 5 Rs Involved in the Tumor Radiobiology of Stereotactic Radiotherapy? David J Brenner (USA), High-Dose and Fractionation Effects in Stereotactic Radiation Therapy. Richard N. Kolesnick (USA), The New Biology of Single-dose Radiotherapy. Yoshiyuki Suzuki (Japan), Radiation-induced Anti-tumor Immunity and its Role in Radiation Therapy. Symposium: International Symposium on Tumor Control by Radiation: Recent Progress in Targeting Hypoxic Tumor Cells: From Bench to Clinic Chairpersons: Bradly G Wouters (Canada), Osamu Inanami (Japan) Murali K Cherukuri (USA), Tumor pO2 and Glycolytic Activity in Pancreatic Cancer Xenografts as Biomarkers to Guide Treatment. Hiroshi Harada (Japan), Hypoxia-inducible Factor 1 (HIF-1): Lessons from Radiation and Tumor Biology. Bradly G Wouters (Canada), Novel Oxygen-sensitive Signaling Pathways Reveal New Therapeutic Targets in Hypoxic Cells. Kazuhiko Ogawa (Japan), Effect of Radiotherapy with Hyperbaric Oxygenation on Malignant Brain Tumors. Katsuyuki Karasawa (Japan), Novel Hypoxic Cell Radiosensitiser—Doranidazole. Friday, May 29 Eye Opener Munira A Kadhim (UK), Recent Studies on Bystander Effects: the Role of Exosomes Cargo in Intra- and Intercellular Communication. Ruth J Muschel (UK), Alterations of Tumour Vasculature: Effects on Tumour Proliferation, Hypoxia and Radiation Response. Marc Benderitter (France), Stem Cell Therapy for the Treatment of Severe Tissue Damage after Radiation Exposure. Marie Anne Herve du Penhoat (France), Dissociation of Ionized Biomolecules: Ab Initio Molecular Dynamics Studies. Yoshinori Sakurai (Japan), The History of the Development of the Neutron Source for Boron Neutron Capture Therapy. Tom K Hei (USA), The Role of Abscopal Effects in Radiation Carcinogenesis. Joachim C Schuz (France), Electromagnetic Fields and Cancer: the Current State of Knowledge and Challenges. Umberto Ricardi (Italy), Oligometastatic Disease and Stereotactic Body Radiotherapy (SBRT). KS Clifford Chao (USA), Imaging-based Adaptive Radiotherapy. [Award Lecture] Henry S Kaplan Distinguished Scientist Award (Kaplan Award) by IARR Ohtsura Niwa (Japan), Attempts to Connect Radiation Epidemiology of Cancer among the Atomic Bomb Survivors to Radiation Biology. Symposium: The Role of Reactive Oxygen Species in the Radiation Response Chairpersons: Kaushala Prasad Mishra (India), Hideyuki J Majima (Japan) Jian Jian Li (USA), Cell Cycle Elements Regulate Mitochondrial Bioenergetics in the Radiation Adaptive Response. Hiroko P Indo (Japan), Roles of Mitochondria-generated Reactive Oxygen Species on X-ray–induced Cell Death in a Human Hepatocellular Carcinoma Cell Line, HLE. Valerian E Kagan (USA), Deciphering Mitochondrial Redox Lipid Signaling in Radiation Damage Leads to Novel Radioprotectors. Kaushala P Mishra (India), Involvement of Reactive Oxygen Species in Herbal Drug–induced Radiosensitivity of Cancer Cells. Tohru Yamamori (Japan), The Relationship between Radiation-induced Cell Cycle Arrest and Reactive Oxygen Species Production from Mitochondria. Symposium: Cell Cycle Regulation in Radiotherapy Chairpersons: Koji Tsuboi (Japan), Woo-Yoon Park (Korea) Masahiko Miura (Japan), Visualizing Cell Cycle Kinetics in HeLa Cells in Vitro and in Vivo Following X-irradiation. Shinichiro Masunaga (Japan), Characteristics of the Response of Intratumor Quiescent (Q) Cells to Irradiation—Referring to Recruitment from Q to the Proliferating State. Woo Yoon Park (Korea), T0070907 Increases Radiosensitivity through G2/M Arrest by Mitotic Catastrophe. Klaus H Dittmann (Germany), Cell Cycle Progression Determines Radiosensitivity. How to Urge a Tumor Cell into a Favorable Cell Cycle phase. Symposium: Benefit–Risk Communication Chairpersons: Lawrence S Lau (Australia), Kazuo Sakai (Japan) Madan M Rehani (USA), Communicating Radiation Risks in Pediatric Imaging. Osamu Miyazaki (Japan), Risk Communication in Japanese Pediatric Radiology after the Fukushima Nuclear Disaster. Rosmini Omar (Malaysia), Perspectives of Patients on Radiology Risk–Benefit Communication. Symposium: The Physical Process of Radiation Damage to Biomolecules and its Cellular Consequences Chairpersons: Sandrine Lacombe (France), Masatoshi Ukai (Japan) Kirill Gokhberg (Germany), The role of Metal Ions in the X-ray Induced Photochemistry of Aqueous Solutions. Akinari Yokoya (Japan), Structure and Repairability of Clustered DNA Damage. Erika Porcel (France), Nanomedicine and Hadrontherapy. Masanori Tomita (Japan), The Effects of DNA Double-strand Break Induction and Repair and Cell Killing by K-shell Absorption of Phosphorus in Human Cell Lines. Symposium: Development of Neutron Source Measurement Chairpersons: Masayori Ishikawa (Japan), Iiro Auterinen (Finland) Hiroki Tanaka (Japan), Development of Real-time Neutron Monitors for BNCT. Hiroaki Kumada (Japan), Development of a New Monte Carlo–Based Treatment Planning System for BNCT. Saverio Altieri (Italy), Preliminary Results on the Spectroscopy Performance of a CdZnTe Detector for Boron Imaging by Single Photon Emission Computed Tomography. Iiro Auterinen (Finland), Characterization of Neutron Beams for Clinical Use in Boron Neutron Capture Therapy (BNCT). Symposium: Recent Progress in Microbeam Research—Non-targeted Effects on the Cells/Tissues Surrounding Irradiated Cells (Joint Session with the 12th International Workshop on Microbeam Probes of the Cellular Radiation Response (IWM2015) Chairpersons: Yasuhiko Kobayashi (Japan), Kevin M Prise (UK) Chunlin Shao (China), Macrophages, Co-cultured with Irradiated Lung Cancer Cells, Play a Role in Triggering Secondary Bystander Effects in Epithelial Cells. Edouard I Azzam (USA), Involvement of Intercellular Communication in Modulating Stressful Effects Propagated from Irradiated to Bystander Cells. Karen J Kirkby (UK), Microbeam Studies of Gold Nanoparticles. David J Brenner (USA), A Super-microbeam with Super-resolution Imaging, at the Radiological Research Accelerator Facility, Columbia University. Hideki Matsumoto (Japan), A Multitudinous Development of Microbeam Radiation Research in Japan. Symposium: The biological Effects of Electromagnetic Fields Chairpersons: Joachim C Schuz (France), Junji Miyakoshi (Japan) Shin Koyama (Japan), Cellular and Molecular Responses to Long-term Exposure to Radiofrequency Radiation (2.45-GHz Microwaves, Millimeter Waves and Terahertz Waves). Guozhen Guo (China), Bio-effects of Electromagnetic Radiation on the Male Reproductive System. Akira Ushiyama (Japan), An Analysis of Radiofrequency Electromagnetic Fields Above and Below Guideline Levels on Gene Expression in Rat Brains. Sachiko Yamaguchi (Japan), Bio-effects of the Static Magnetic Field and Assessment of Occupational Magnetic Field Exposure Among MR Workers. Naoki Shinohara (Japan), Characteristics of Electromagnetic Waves and Novel Applications for Wireless Power Transfer. Symposium: Most Updated Clinical Evidence for SBRT Chairpersons: Hiroshi Onishi (Japan), Laura Dawson (Canada) Yasushi Nagata (Japan), Current Status of Stereotactic Body Radiation Therapy (SBRT) in Japan. Carlo Greco (Portugal), Single-Dose IGRT for Oligometastases. Robert D Timmerman (USA), Stereotactic Ablative Radiotherapy (SABR): a Local Therapy Poised to Fight Both Early and Metastatic Lung Cancer. Joe Y Chang (USA), Stereotactic Ablative Radiotherapy: Can Local Plus Systemic Control Lead to a Cancer Cure? Laura A Dawson (Canada), Hepatobiliary Carcinoma SBRT: Ready for Prime Time? Symposium: Adaptive Radiation Therapy Chairpersons: Shuichi Ozawa (Japan), Clifford Chao (USA) Di Yan (USA), Adaptive Radiotherapy: Current Status and Challenge. Laurence E Court (USA), The Use of Quantitative Image Features to Guide Adaptive Radiation Therapy. David Schwartz (USA), TBA. Mischa S Hoogeman (The Netherlands), Clinical Implementation of an Online Adaptive Plan-of-the-day Protocol for Non-rigid Motion Management in Locally Advanced Cervical Cancer IMRT. Yasumasa Nishimura (Japan), The Necessity of Adaptive Radiation Therapy (ART) for Head and Neck Cancer. 2. Message 2.1 Message from the President of ICRR2015 (Masahiro Hiraoka) It is our great honor and pleasure to have the 15th International Congress of Radiation Research (ICRR2015) here in Kyoto in Japan. Radiation science is an important and comprehensive research area that covers many branches, including radiation-related physics, chemistry, biology and medicine, each of which has progressed remarkably in recent years. Furthermore, radiation science is nowadays an advanced science that is tightly linked to human societies and the planet earth. We have to consider how our daily research can contribute to the development of human society and the preservation of the global environment. The application of radiation technology to mankind has also greatly expanded, especially in medical fields such as radiology, nuclear medicine and radiation oncology. Recognizing these things, we selected as the theme of ICRR 2015 ‘Radiation Science—Shaping the Future of the Earth and Mankind’. Two plenary lectures (delivered by Emeritus Professor Arima and by Professor Yamanaka), 2 special lectures, 28 congress lectures, 33 eye openers, and 63 symposia have been coordinated, in which the latest achievements in radiation science will be presented and discussed. We appreciate the contribution of the 463 invited speakers who have come to Kyoto from all over the world for those special sessions. Presumably, the more important issues to be assessed in an International Congress are the number of proffered papers and the number of participants. I am pleased to announce that the total number of registered attendants is nearly 1800 (from 53 countries) and that 1122 papers have been submitted to this congress. Each of these three statistics is the largest in the history of ICRR. This accomplishment was possible with the support of IARR, JARR (Japanese Association of Radiation Research), ERRS, RRS, ARRS, ESTRO, ASTRO, FARO and more than 10 societies, institutes and organizations that hold sponsored symposia. We should give special thanks to JRRS, ERRS, the Japan Society of Radiation Chemistry, the International Association for the Sensitization of Cancer Treatment, and the radiation biology group of JASTRO, which jointly organize the annual meeting in this Congress. To encourage young scientists, the Young Investigator's Travel Award was provided to 142 participants. It is with great pleasure that I would like to inform you of an exciting event organized by young investigators in Japan—a ‘Get Together for Young Investigators’ will be held during this congress, where international friendship and scientific communication beyond countries and research fields is expected to be facilitated and to flourish. Kyoto is a home town of Japanese cultures and a rich social program has been prepared for ICRR, including a Japanese Art performance, Sake (Rice wine) tasting, and a gala dinner held at the Toei Kyoto Studio Park, the first theme park in Japan. I do hope your stay in Kyoto will be fruitful and enjoyable in terms of both scientific achievements and cultural experiences. Finally, I should like to thank Dr Marco Durante (President of IARR), Dr Takeo Onishi (President of JARR), Dr Kenji Kamiya (Secretary General of ICRR2015), Dr Kiyoshi Miyagawa and Koji Ono (Vice-president), Dr Fumio Suzuki (Deputy Secretary General), all of the Committee members, and various sponsors, without whom this congress would not have been realized. I now declare the opening of the 15th ICRR. Thank you very much. 2.2 Message from the President of JARR (Takeo Ohnishi) Welcome to Kyoto Japan. The last time the International Congress of Radiation Research was held in Japan was the 6th Congress in Tokyo in 1979. The members of the Japanese Association for Radiation Research, the JARR, represent researchers in many fields of Radiation Biology, Radiation Chemistry, Radiation Physics, Environmental Radiation and Radiation Medicine. The JARR proposed to hold this congress in Japan several times, and we have been hoping to host this meeting for a very long time. Today, we are honored to have finally succeeded, and are once again hosting this ICRR. We are very enthusiastic at being able to host this Congress for the second time this year, the 15th ICRR in Kyoto, Japan. As president of the JARR, I appreciate the generous contributions made by the president, Dr Masahiro Hiraoka, and all of the members of the organizing committee, and I would like to congratulate them for the successful outcome of their efforts at the opening of the 15th ICRR. More than 100 years ago, Wilhelm Conrad RÖntgen recognized the phenomenon of radiation, and Maria Skłodowska-Curie identified radioisotopes; they each received a Nobel prize for their work. Since that time, many scientists have studied radiation and have applied their observations and insights to many areas, including human health. This is reflected in recent progress in studies of radiation and radioisotopes, which have been very useful in medical fields and in improving human lives. We would like to note that there has been remarkable progress in the understanding of radiation, and also in applying these new insights in radiation and radioisotopes to the studies of biological systems at the molecular level. However, in contrast to these hopes, the huge earthquake and Tsunami in Eastern Japan on March 11, 2011 led to the subsequent Fukushima nuclear power plant accident. This disaster resulted in the release of a substantial quantity of radioisotopes into the atmosphere. Since the Fukushima accident happened, Japan has intensively studied the effects of radiation and radioisotopes in efforts to protect human health. In addition, efforts to educate the general population about radiation and its effects have become more important. Therefore, the opening of this congress is very significant for Japan. I hope that elevated levels of scientific presentations and discussions on the benefits and risks of radiation and radioisotopes during this congress will further advance all of our fields. I also hope that the scientific presentations and discussions during the ICRR will result in benefits to people all around the world. Welcome to Japan and to Kyoto. We hope you will enjoy the scientific presentations at the ICRR and the Japanese culture in Kyoto. Thank you very much. 2.3 Message from the IARR president (Marco Durante) Professor Hiraoka, dear Colleagues, I'd like to personally welcome each of you to the 15th International Congress of Radiation Research. Thank you for coming. That many of you travel long distances—including myself!—serves to remind us all just how important our work is. Radiation research is an exciting area in which to work and study, and we will continue to meet and bring inspired people and young students together in forums like this to ensure that our organization remains at the cutting edge. Let me give you a brief update on where we are today. The last ICRR meeting was in Warsaw and started only a few months after the Fukushima accident. After four years we meet here, in Japan, and our first thought must go to the thousands of victims who were killed in the devastating earthquake and tsunami on March 11, 2011. “It's a terrible thing when a person dies, whatever the circumstances. A hole opens up in the world, and we need to pay the proper respects. If we don't, the hole will never be filled in again.” I will borrow the words from Haruki Murakami, a famous writer from Kyoto: In the past four years, the Japanese radiation research community, and along with them radiation researchers from all over the world, have paid the proper respect to those victims. Radiation protection studies have greatly enhanced our knowledge and understanding of the effects of low doses of ionizing radiation, and in this meeting (and in the satellite workshop on dose reconstruction in Fukushima following the ICRR) we will learn about the most recent studies on radioprotection and radioecology in the aftermath of the Fukushima tragedy. It is an exciting time for radiation therapy, too. In the past four years, we have seen a rapid growth in stereotactic body treatments, with hypofractionation now becoming a standard in clinical practice. Charged particle therapy is rapidly growing all over the world, and Japan has pioneered this technique. The National Institute for Radiological Sciences in Chiba, the first institute to treat patients with high-energy carbon ions, celebrated 20 years of clinical treatments last year, and its example is being followed by several other centers outside Japan: in China, in Europe and, in the next four years, also in the USA. In the next few days, you will have the opportunity to hear about all the recent advances in radiation research. With 33 conference lectures, 33 eye openers, 63 symposia, 27 oral sessions, 18 luncheon seminars and hundreds of posters, you will all find something interesting and new. Prepare yourself to be challenged, excited and inspired. This is my last week as President of the International Association for Radiation Research. The new President will close this meeting and announce the next ICRR in 2019. There are many people I would like to thank for giving me this honor and helping me in this office. “I want to thank everyone I ever met in my whole life!” said Maureen Stapelton winning her Academy Award—that's how I feel as well, but there is not much time! Certainly I want to thank the Treasurer–Secretary of the Society, Prof. Gianfranco Grossi, who is also stepping down, and the past President, Prof. Ohtsura Niwa. He is the well-deserved recipient of the Kaplan award, and you will have the opportunity to listen to his seminar on Friday. Before I close, I'd like to thank again each of you for attending our conference and bringing your expertise to our gathering. You have the vision, the knowledge, the wherewithal and the experience to pave our way into the future. Throughout this conference, I ask you to stay engaged, keep us proactive and help us shape the future of radiation research. My personal respect and thanks goes out to all of you. Domo arigato gozaimashita. 2.4 Message from the President of the Radiation Research Society (Gayle E Woloschak) The Radiation Research Society expresses its sincere appreciation to the organizing committee of the 15th International Congress of Radiation Research held in Kyoto Japan on May 25–29, 2015 for presenting to the world an exemplary Congress, rich in outstanding scientific research, and yet also affording participants a small experience in Japanese culture. This meeting focused on the theme ‘Radiation Science—Shaping the Future of the Earth and Mankind’ and included cutting-edge presentations that covered the whole range of the radiation sciences from clinical research to physics to radiation protection. The accident at the Tokyo Electric Power Company's Fukushima Dai-ichi nuclear power plant after the Great East Japan Earthquake and Tsunami affected the world, mainly because of concerns about radiation leakage and exposure. ICRR2015 provided an ideal platform for summarizing information about the accident itself, and presenting the subsequent radiation and societal findings that have resulted from studies that were a follow-up to the accident. Radiation medicine is an interdisciplinary field, with significant contributions coming from the disciplines of physics, chemistry, biology and medicine, all of which are recognized as essential by the Radiation Research Society. The ICRR 2015 emphasized this multidimensional character of the field, and highlighted the many new discoveries that have contributed to progress in cancer treatment, including heavy-ion therapy, proton therapy and many other techniques. Innovations in Japan and around the world were discussed extensively at the Congress, and are likely to have an impact on the world radiation community for years to come. Kyoto also proved to be an ideal location for the Congress. The academic treasures of the city were on display throughout the Congress, and at several of the related satellite meetings, and the cultural environment and history of the city added an important and exciting contribution to the positive experiences of the participants in the Congress. Japan has once again set a very high standard as international hosts. It is with great pleasure and admiration that the Radiation Research Society extends its congratulations and thanks to Dr Masahiro Hiraoka (President), Dr Kenji Kamiya (Secretary-General) and the entire planning committee of the 15th International Congress of Radiation Research for organizing an outstanding Congress. 2.5 Message from the European Society for Radiation Research The 15th International Congress of Radiation Research (ICRR 2015), held in Kyoto, Japan, in May 2015, was organized under the general theme of ‘Radiation Science—Shaping the Future of the Earth and Mankind’. This theme is completely in line with the mission and aims of our society, i.e. ‘To promote radiation research and distribution of scientific knowledge in all aspects of radiation science’. ERRS greatly appreciated the invitation to participate in the scientific organization of this congress, and welcomed the opportunity to integrate the annual, society-specific events, such as the Young Investigator Award presentations and the ‘Bacq and Alexander’ award lecture, into the scientific programme of the congress. The organization of the meeting, with regard to both scientific and social aspects, was excellent. Kyoto International Conference Center provided an optimal environment for the scientific sessions as well as the social events such as the Welcome Reception and the Young Investigators Get-together. The Gala Dinner turned out to be a rather exciting tour through the exotic atmosphere of the Japanese Ninja and Samurai culture of the Edo historical period. Kyoto, the City of Ten Thousand Shrines, was a wonderful and exquisite place to experience. Fully in line with the general theme of the congress, the scientific topics were highly interdisciplinary and covered all aspects of radiation science. Some specific topics, related to the location of ICRR 2015, were highlighted in particular sessions and lectures, such as the consequences and conclusions from the Fukushima accident, and recent results concerning induced stem cells. A deeper appreciation of the most recent scientific results and progress, plus the widespread sharing of data among members of the various scientific societies like ours will undoubtedly promote a better understanding of the mechanisms of action of radiation. This will certainly contribute to the safe and optimized use of radiation in all relevant disciplines, including medicine, which will in turn lead to better protection of the environment, as well as to a significant benefit for human health. With this message, ERRS congratulates the President of ICRR 2015, Prof. Masahiro Hiraoka, the Secretary-General, Prof. Kenji Kamiya, the entire scientific committee and all the staff involved on the excellent practical organization and the great success of this Congress. 2.6 Message from the European Society for Radiotherapy & Oncology (ESTRO) In the framework of our long tradition of friendship and collaboration with JASTRO, ESTRO was pleased to support the 15th edition of the ICRR. In agreement with Prof. Masahiro Hiraoka (President) and Prof. Kenji Kamiya (Secretary-General of the meeting), ESTRO appointed three members to the scientific committee of the meeting: Núria Jornet, Brad Wouters and Philip Poortmans, who helped to shape the excellent scientific profile of the congress, in close collaboration with all the members of the scientific committee chaired by Prof. Kazuo Sakai and Prof. Yasumasa Nishimura. International collaboration in the field of radiation research includes research into the radiation used to treat malignant diseases. The progress made in the clinical, physical and biological aspects of research into the special field of radiation oncology over the last few decades is overwhelming. From what was often a mere additive treatment after surgery or an approach to relieve symptoms due to local or metastatic incurable tumors, radiation therapy has evolved into a highly effective curative treatment modality, often used in combination with surgical or systemic treatments. Palliation can be delivered in a very effective way, often with only one or a small number of fractions. Organ-sparing treatment—avoiding the functional, social and emotional consequences of total removal of an organ or structure—is now available for many patients, especially for those with breast, head and neck, prostate, anal and some gynecological cancers. With highly directed treatments, small primary and metastatic tumors in organs such as lungs or liver can be treated with radiotherapy as effectively as surgical removal. The future lies in individualization of the optimal (most effective and least toxic) combination of local and systemic treatments for each specific patient and tumor, taking into account the patient's specific circumstances. The synergy between the parallel development of intensity-modulated treatment delivery and on-board image-guidance, paved the way for more efficient treatments and indeed the exploration of challenging dose fractionations. An even more promising challenge is the clinical implementation of adaptive radiation therapy, where the combination of highly conformal dose distributions (using different dose levels to anticipate tumor heterogeneity) and real-time imaging allows us to adapt the original treatment plan to variations in anatomy (both gradual changes that occur during the course of treatment as well as managing for example respiratory-induced motion during actual dose delivery) and/or tumor response. Equally important is the challenge of combining radiation therapy with chemotherapy, targeted therapy, or immune therapy in a patient-individualized manner that maximizes tumor control while minimizing normal tissue toxicity. As such, state-of-the-art radiation therapy has become a truly individualized and targeted treatment. Today, thanks to these advances in treatment delivery and the progress made in the field of dose calculation, we can make an accurate estimation of the dose received by the different organs and tissues. This, together with the advances in quantitative imaging for toxicity and tumor control monitoring, puts us in a privileged position to model and better understand dose–volume effects in tumors as well as in healthy tissue. This illustrates the continuously progressive bridging between physics, clinical oncology and radiobiology. Multidisciplinary and international collaboration is key in these developments that require open fora and a fertile soil for integrated large-scale clinical implementation of these new concepts. Concluding, we very much support the inclusion of all aspects of radiation oncology as an integral part of the International Congress of Radiation Research, together with all other scientific, clinical, physical, environmental and social aspects related to the use of radiation for peaceful goals. ESTRO also looks forward to further building on the scientific and educational collaboration with JASTRO and the broader radiation oncology community as well as with the radiation research community. Platforms such as MELODI, in which ESTRO is a partner, show the importance of joining efforts from clinical and basic research to better understand the effect of low doses of radiation on human beings. Kind regards from Núria Jornet, Dirk Verellen, Brad Wouters, Daniel Zips, Philip Poortmans and the ESTRO Office in Brussels, Europe, 11 August 2015.