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      Discontinuity in the cancer slope factor as it passes from high to low exposure levels--arsenic in the BFD-endemic area.

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          Abstract

          The ingestion of inorganic arsenic causes bladder and lung cancers demonstrably at >400-500ug/L but questionably below 100-200ug/L. Using the standard 42-village cancer mortality dataset from the Blackfoot-disease (BFD) endemic area of southwest Taiwan (Wu et al., 1989), we examined the risk from low exposures by excluding the high exposures.

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          Author and article information

          Journal
          Toxicology
          Toxicology
          Elsevier BV
          1879-3185
          0300-483X
          Dec 04 2014
          : 326
          Affiliations
          [1 ] Center for Epidemiology and Global Health, CEOH, LLC., Washington, D.C., USA; Johns Hopkins University-Bloomberg School of Public Health, Baltimore, MD, USA; Georgetown University School of Medicine, Washington, D.C., USA. Electronic address: Steve@ceoh.com.
          [2 ] Center for Epidemiology and Global Health, CEOH, LLC., Washington, D.C., USA.
          [3 ] Georgetown University Graduate School, Washington, D.C., USA.
          [4 ] American University Department of Mathematics, Washington, D.C., USA.
          [5 ] Johns Hopkins University-Bloomberg School of Public Health, Baltimore, MD, USA.
          Article
          S0300-483X(14)00176-0
          10.1016/j.tox.2014.08.014
          25241138
          f1e90041-7642-44a9-ab87-b5424e8aa418
          History

          Arsenic,Bladder cancer,Dose-response,Low level exposure,Lung cancer,Southwest Taiwan

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