Brucellar reproductive system injury: A retrospective study of 22
cases and review of the literature

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Abstract

Objective

We aimed to describe the clinical characteristics and prognosis of 22 patients with Brucella-induced reproductive system injury.

Methods

We assessed 22 patients with reproductive system injury between 2010 and 2018 at The First Affiliated Hospital of Xinjiang Medical University.

Results

The disease is predominant in men. Male patients had orchitis, erectile dysfunction, prostatitis, and urethral stricture, while female patients had vaginitis and cervicitis. Some patients had laboratory abnormalities and liver injury. Patients received combination therapy of rifampicin and doxycycline. Doxycycline combined with levofloxacin or moxifloxacin was administered to patients with rifampicin intolerance. All patients had received antibiotic therapy for at least 6 weeks. One patient was lost to follow-up, one patient relapsed because of osteoarthropathy, and one patient had dysuria resulting from chronic prostatitis. The clinical symptoms resolved in the other patients, and the overall patient prognosis was good.

Conclusion

Clinicians should pay attention to brucellosis-induced reproductive system damage. The two-drug regimen of rifampicin+doxycycline is recommended for these patients. Doxycycline combined with levofloxacin or moxifloxacin should be used in patients with brucellosis-induced reproductive system damage who have rifampicin intolerance. The treatment course should be at least 6 weeks.

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Most cited references 12

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Human brucellosis.

Maria Franco, Maximilian Mulder, Robert Gilman … (2007)

Human brucellosis still presents scientists and clinicians with several challenges, such as the understanding of pathogenic mechanisms of Brucella spp, the identification of markers for disease severity, progression, and treatment response, and the development of improved treatment regimens. Molecular studies have shed new light on the pathogenesis of Brucella spp, and new technologies have permitted the development of diagnostic tools that will be useful in developing countries, where brucellosis is still a very common but often neglected disease. However, further studies are needed to establish optimum treatment regimens and local and international control programmes. This Review summarises current knowledge of the pathogenic mechanisms, new diagnostic advances, therapeutic options, and the situation of developing countries in regard to human brucellosis.

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An overview of human brucellosis.

Susan Young (1995)

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Human brucellosis in Macedonia - 10 years of clinical experience in endemic region.

Zaklina Sopova, Katerina Spasovska, Marija Dimzova … (2010)

To present our 10-year clinical experience with brucellosis patients at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia. A total of 550 patients with brucellosis treated between 1998 and 2007 were retrospectively assessed for their demographic, epidemiological, and clinical characteristics and outcomes. Of the 550 patients, 395 (72%) were male. The median age was 34.5 years (range, 1-82). Direct contact with infected animals was recorded in 333 (61%) patients and positive family history in 310 (56%). The most frequently seen symptoms were arthralgia (438, 80%), fever (419, 76%), and sweating (394, 72%). The most common signs were fever and hepatomegaly, which were verified in 357 (65%) and 273 (50%) patients, respectively. Focal brucellosis was found in 362 patients (66%) and osteoarticular in 299 (54%). Therapeutic failures were registered in 37 (6.7%) patients. Of the 453 (82%) patients who completed a follow-up period of at least 6 months, relapses occurred in 60 (13%). Due to non-specific clinical manifestation and laboratory parameters, brucellosis should be considered one of the differential diagnoses of any patient suffering from obscure involvement of various organs in a brucellosis-endemic region. High percentage of relapses and therapeutic failures in spite of the use of currently recommended therapeutic regimens indicates the seriousness of this zoonosis and the need to control it.

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Author and article information

Journal

Journal ID (nlm-ta): J Int Med Res

Journal ID (iso-abbrev): J. Int. Med. Res

Journal ID (publisher-id): IMR

Journal ID (hwp): spimr

Title: The Journal of International Medical Research

Publisher: SAGE Publications (Sage UK: London, England )

ISSN (Print): 0300-0605

ISSN (Electronic): 1473-2300

Publication date (Electronic): 18 June 2020

Publication date Collection: June 2020

Volume: 48

Issue: 6

Electronic Location Identifier: 0300060520924548

Affiliations

[1 ]Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

[2 ]The First Hospital of Shihezi University, Shihezi, Xinjiang, China

[3 ]Department of Immunology, Basic Medical College, Xinjiang Medical University, Urumqi, China

Author notes

[*]Yuexin Zhang, Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. Email: zhangyx3103@ 123456163.com

Author information

Yan Zhou https://orcid.org/0000-0002-8908-7688

Songsong Xie https://orcid.org/0000-0003-0307-6425

Article

Publisher ID: 10.1177_0300060520924548

DOI: 10.1177/0300060520924548

PMC ID: 7303501

PubMed ID: 32552113

SO-VID: f2ef7db4-cddd-4e28-93cb-ad54515210e9

License:

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

History

Date received : 29 September 2019

Date accepted : 16 April 2020

Funding

Funded by: Key Research and Development Projects of the Xinjiang Uygur Autonomous Region;

Award ID: No. 2016B03047-1

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Keywords: brucellosis,reproductive system,clinical features,rifampicin intolerance,doxycycline,levofloxacin,moxifloxacin

Data availability:

Keywords: brucellosis, reproductive system, clinical features, rifampicin intolerance, doxycycline, levofloxacin, moxifloxacin

Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature

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Abstract

Objective

Methods

Results

Conclusion

Related collections

International Journal of Medicine and Medical Research

Most cited references 12

Human brucellosis.

An overview of human brucellosis.

Human brucellosis in Macedonia - 10 years of clinical experience in endemic region.

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