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      Carbazole alkaloids isolated from the branch and leaf extracts of Clausena lansium

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          Abstract

          The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1–9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2–6 exhibited varying degrees of cytotoxicity to cancer cells, with IC 50 values ranging from 8.67 to 98.89 µmol·L −1.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 July 2018
          : 16
          : 7
          : 509-512
          Affiliations
          1College of Agriculture, Jiangxi Agricultural University, Nanchang 330045, China
          2Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China
          3Jiangxi Yichun University, Yichun 336000, China
          Author notes
          *Corresponding author: PENG Wen-Wen, Tel: 86-791-83813185, E-mail: peng-wenwen123@ 123456sina.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30087-6
          10.1016/S1875-5364(18)30087-6
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 31660094
          This work was supported by the National Natural Science Foundation of China (No. 31660094)

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