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      From bark to weed: The history of artemisinin Translated title: De l’écorce à l’herbe : Histoire de l’artémisinine

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          Abstract

          In the 1970’s, in China, some brilliant and courageous scientists carried out a research programme, which lead to the discovery of artemisinin derivatives and new quinoleines that are used today, in combination, as first line treatment of malaria.

          Translated abstract

          Dans les années 1970, de remarquables et courageux scientifiques chinois réalisèrent un programme de recherche qui conduisit à la découverte de dérivés de l’artémisinine et de nouvelles quinoléines qui sont maintenant, en association, des traitements de première ligne du paludisme.

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          Most cited references 4

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          Averting a malaria disaster.

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            An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb.

             Ying Li,  Fe-Lin Wu (2003)
            This article reviews the discovery and the further studies on qinghaosu and its derivatives or analogs over the last decades in the fields of medicinal chemistry and some pharmacology research, with an emphasis on the progress achieved in China.
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              An overview of the clinical use of artemisinin and its derivatives in the treatment of falciparum malaria in Viet Nam.

               T T Hien (1994)
              In order to combat increasing problems with drug resistance in Plasmodium falciparum, Viet Nam has turned increasingly to the artemisinin derivatives. Oral and suppository formulations of artemisinin are produced from locally grown plants. These compounds have been rapidly effective in a large number of studies and have proved of particular value in severe malaria. Artemisinin suppositories are as effective as the parenteral drugs and offer the prospect of a simple, safe and inexpensive method of treating severe malaria in rural areas.
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                Author and article information

                Journal
                Parasite
                Parasite
                parasite
                Parasite : journal de la Société Française de Parasitologie
                EDP Sciences
                1252-607X
                1776-1042
                August 2011
                15 August 2011
                : 18
                : 3 ( publisher-idID: parasite/2011/03 )
                : 215-218
                Affiliations
                Consultant, East West Pharmaceuticals 189, rue Grande 77300 Fontainebleau France
                Author notes
                [* ]Correspondence: Claude Faurant. E-mail: claude.faurant@ 123456east-west-pharmaceuticals.com
                Article
                parasite2011183p215 10.1051/parasite/2011183215
                10.1051/parasite/2011183215
                3671478
                21894261
                © PRINCEPS Editions, Paris, 2011

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Page count
                Figures: 1, Tables: 1, Equations: 0, References: 17, Pages: 4
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