High prevalences of HIV and other sexually transmitted infections (STIs) have been
reported in the current global monkeypox outbreak, which has affected primarily gay,
bisexual, and other men who have sex with men (MSM) (
1
–
5
). In previous monkeypox outbreaks in Nigeria, concurrent HIV infection was associated
with poor monkeypox clinical outcomes (
6
,
7
). Monkeypox, HIV, and STI surveillance data from eight U.S. jurisdictions* were matched
and analyzed to examine HIV and STI diagnoses among persons with monkeypox and assess
differences in monkeypox clinical features according to HIV infection status. Among
1,969 persons with monkeypox during May 17–July 22, 2022, HIV prevalence was 38%,
and 41% had received a diagnosis of one or more other reportable STIs in the preceding
year. Among persons with monkeypox and diagnosed HIV infection, 94% had received HIV
care in the preceding year, and 82% had an HIV viral load of <200 copies/mL, indicating
HIV viral suppression. Compared with persons without HIV infection, a higher proportion
of persons with HIV infection were hospitalized (8% versus 3%). Persons with HIV infection
or STIs are disproportionately represented among persons with monkeypox. It is important
that public health officials leverage systems for delivering HIV and STI care and
prevention to reduce monkeypox incidence in this population. Consideration should
be given to prioritizing persons with HIV infection and STIs for vaccination against
monkeypox. HIV and STI screening and other recommended preventive care should be routinely
offered to persons evaluated for monkeypox, with linkage to HIV care or HIV preexposure
prophylaxis (PrEP) as appropriate.
Eight health departments matched probable and confirmed cases of monkeypox
†
diagnosed through July 22, 2022, and occurring among persons aged ≥18 years, to local
HIV and STI surveillance data using individually established methods that included
various personal identifiers (e.g., name, soundex,
§
date of birth, address, and telephone number). Matched data were deidentified and
securely transmitted to CDC for analysis.
Among persons with monkeypox, prevalence of diagnosed HIV infection, determined through
local HIV surveillance matches,
¶
was calculated. HIV surveillance data were used to assess receipt of HIV care,** HIV
viral suppression (an indication of antiretroviral therapy use),
††
most recent CD4 count,
§§
and time since HIV diagnosis (
8
). STI surveillance data were used to assess chlamydia, gonorrhea, and syphilis diagnoses.
Monkeypox signs, symptoms, and outcomes were compared according to HIV infection status.
This activity was reviewed by CDC and was conducted consistent with applicable federal
law and CDC policy.
¶¶
Among 1,969 persons aged ≥18 years with monkeypox diagnosed during May 17–July 22,
2022, in eight participating jurisdictions, 755 (38%) had received an HIV diagnosis,
816 (41%) had another reportable STI diagnosed in the preceding year, and 363 (18%)
had both; 1,208 (61%) persons had either (Table 1) (Table 2).*** Since May 1, 2022,
19 (1%) persons with monkeypox had received an HIV diagnosis, and 297 (15%) had received
an STI diagnosis. Persons with monkeypox and HIV infection more commonly had received
an STI diagnosis in the preceding year (48%) than had those without HIV infection
(37%).
TABLE 1
Demographic characteristics of persons with monkeypox and HIV infection* — eight U.S.
jurisdictions,
†
May 17–July 22, 2022
Characteristic
No. of persons with monkeypox
No. of persons with monkeypox and diagnosed HIV infection
HIV prevalence among persons with monkeypox (row %)
Total
1,969
755
38
Age, median, yrs (IQR)
35 (30–42)
38 (32–45)
—
Age group, yrs
18–24
106
22
21
25–34
801
246
31
35–44
670
291
43
45–54
278
131
47
≥55
105
62
59
Missing
9
3
33
Sex assigned at birth
Male
1,466
548
37
Female
10
0
—
Missing or declined to answer
493
207
42
Gender identity
Man
1,888
730
39
Woman
7
1
14
Transgender man or woman
8
0
—
Another gender identity
14
2
14
Missing or declined to answer
52
22
42
Race and ethnicity
Asian, non-Hispanic
89
20
22
Black or African American, non-Hispanic
409
256
63
Hispanic or Latino§
158
64
41
Other¶
169
61
36
White, non-Hispanic
919
255
28
Missing
225
99
44
Monkeypox report date**
May 15–Jun 4
24
3
13
Jun 5–11
35
9
26
Jun 12–18
64
13
20
Jun 19–25
110
32
29
Jun 26–Jul 2
201
65
32
July 3–9
331
104
31
Jul 10–16
498
196
39
Jul 17–23
596
264
44
Missing
110
69
63
* Persons with self-reported HIV infection who did not match to local HIV surveillance
data (39) were excluded from the analysis.
† Eight state and city or county jurisdictions independently funded for HIV surveillance:
California (including Los Angeles County and San Francisco), District of Columbia,
Georgia, Illinois (including Chicago), and New York (excluding New York City).
§ Hispanic or Latino persons can be of any race.
¶ Other includes persons who identify as Native Hawaiian and other Pacific Islander,
American Indian or Alaska Native, or multiracial, and persons who declined to report.
** Report date includes either date of specimen collection, Orthopoxvirus test, monkeypox
diagnosis by clinician, illness onset, or rash onset. Report date shown by epidemiologic
week; the first 3 weeks of the outbreak are combined because of small numbers.
TABLE 2
Monkeypox hospitalization, sexually transmitted infections, and HIV prevention and
care characteristics, by HIV infection status* — eight U.S. jurisdictions,
†
May 17–July 22, 2022
Characteristic
No. (%) of persons with monkeypox§
No. (%) of persons without diagnosed HIV infection§
No. (%) of persons with diagnosed HIV infection§
Total
1,969
1,214
755
Hospitalization during monkeypox illness
Hospitalized for monkeypox¶
68 (5)
26 (3)
42 (8)
Duration of hospitalization, median, days (range)**
3 (0–10)
3 (0–10)
2 (0–7)
History of STIs
Reportable STI diagnosis during preceding yr
816 (41)
453 (37)
363 (48)
Gonorrhea
546 (28)
307 (25)
239 (32)
Chlamydia
489 (25)
278 (23)
211 (28)
Syphilis
165 (8)
69 (6)
96 (13)
STI diagnosis since May 1, 2022
297 (15)
166 (14)
131 (17)
No. of STIs diagnosed during preceding yr
1
396 (20)
220 (18)
176 (23)
2
222 (11)
117 (10)
105 (14)
≥3
198 (10)
116 (10)
82 (11)
HIV prevention and care characteristic
Received HIV care in preceding yr††
NA
NA
713 (94)
Suppressed HIV viral load§§
NA
NA
618 (82)
Recent CD4 count cells/μL, median (IQR)¶¶
NA
NA
639 (452–831)
CD4 count <350 cells/μL
NA
NA
91 (12)
CD4 count <200 cells/μL
NA
NA
25 (3)
Yrs since HIV diagnosis, median (IQR)
NA
NA
10 (6–15)
HIV diagnosis since May 1, 2022
NA
NA
19 (3)
Current HIV PrEP use***
NA
115 (67)
NA
Abbreviations: NA = not applicable; PrEP = preexposure prophylaxis; STI = sexually
transmitted infection.
* Persons with self-reported HIV infection who did not match to local HIV surveillance
data (39) were excluded from the analysis.
† Eight state and city or county jurisdictions independently funded for HIV surveillance:
California (including Los Angeles County and San Francisco), District of Columbia,
Georgia, Illinois (including Chicago), and New York (excluding New York City).
§ Row percentages calculated using nonmissing data.
¶ Overall, 1,308 persons had data available for hospitalization, including 798 persons
without diagnosed HIV infection and 510 persons with diagnosed HIV infection.
** Overall, 48 hospitalized persons had data available for hospitalization duration,
including 18 persons without diagnosed HIV infection and 30 persons with diagnosed
HIV infection.
†† Receipt of HIV care was defined as at least one HIV viral load or CD4 test since
May 1, 2021; tests conducted during evaluation for monkeypox might have been included.
§§ HIV viral suppression was defined as the most recent HIV viral load <200 copies/mL
since May 1, 2021.
¶¶ Recent CD4 count was defined as the most recent CD4 count since May 1, 2021.
*** Among persons without diagnosed HIV infection, 172 persons had data available
for current HIV PrEP use.
Among persons with monkeypox, the weekly percentage with concurrent HIV infection
increased over time (31%–44% by July). The percentage of persons with monkeypox who
had HIV infection was higher in older age groups: among persons aged 18–24 years,
HIV prevalence was 21%, and among those aged ≥55 years, was 59%. HIV prevalence among
persons with monkeypox also varied by race and ethnicity, ranging from a high of 63%
among non-Hispanic Black or African American (Black) persons, to 41% among Hispanic
or Latino (Hispanic) persons, 28% among non-Hispanic White persons, and 22% among
non-Hispanic Asian persons.
Among 755 persons with monkeypox and HIV infection, 713 (94%) received HIV care in
the preceding year, 618 (82%) were virally suppressed, and 586 (78%) had CD4 count
≥350/μL. The median interval since HIV diagnosis was 10 years (IQR = 6–15 years).
Data on HIV PrEP use were available for 172 (14%) persons without HIV infection, 115
(67%) of whom reported current PrEP use.
Compared with persons with monkeypox who did not have HIV infection, those with HIV
infection were more likely to report rectal pain (34% versus 26%), tenesmus (20% versus
12%), rectal bleeding (19% versus 12%), purulent or bloody stools (15% versus 8%),
and proctitis (13% versus 7%), but were less likely to report lymphadenopathy (48%
versus 53%) (Figure). The prevalence of other signs and symptoms was similar among
persons with monkeypox with and without HIV infection. Among 564 persons with monkeypox,
HIV, known HIV viral load values, and signs and symptoms data, the 51 persons with
unsuppressed HIV viral load were more likely than were the 513 with suppressed viral
load to have lymphadenopathy (59% versus 46%), generalized pruritis (59% versus 42%),
rectal bleeding (25% versus 18%), and purulent or bloody stools (22% versus 14%).
Compared with persons with CD4 counts ≥350/μL, those with CD4 counts <350/μL more
commonly experienced fever (69% versus 59%) and generalized pruritis (53% versus 42%).
FIGURE
Signs and symptoms of monkeypox,*
,
†
by HIV infection status
§
— eight U.S. jurisdictions,
¶
May 17–July 22, 2022
* Persons with self-reported HIV infection who did not match to local HIV surveillance
data (39) were excluded from the analysis.
† Signs and symptoms were not mutually exclusive.
§ Percentages calculated using nonmissing data. Overall, 1,707 persons had data available
for signs and symptoms except proctitis, including 1,082 persons without diagnosed
HIV infection and 625 persons with diagnosed HIV infection. For proctitis, data were
available for 393 persons without diagnosed HIV infection and 304 persons with diagnosed
HIV infection.
¶ Eight state and city or county jurisdictions independently funded for HIV surveillance:
California (including Los Angeles County and San Francisco), District of Columbia,
Georgia, Illinois (including Chicago), and New York (excluding New York City).
This figure is a horizontal bar chart indicating the prevalence of signs and symptoms
of monkeypox, by HIV infection status in eight U.S. jurisdictions during May 17–July
22, 2022.
Among 1,308 (66%) persons with information on hospitalization, the proportion of persons
hospitalized with monkeypox was lower among those without HIV infection (3%, 26 of
798) than among those with HIV infection (8%, 42 of 510). Among 45 persons with monkeypox
and HIV infection who were not virally suppressed, 12 (27%) were hospitalized, and
among 61 with a CD4 count <350 cells/μL, nine (15%) were hospitalized.
Discussion
Among persons with monkeypox in eight U.S. jurisdictions, prevalences of concurrent
HIV infection and reportable STI diagnoses within the preceding 12 months were high,
consistent with previous reports (
1
–
5
). To date, most U.S. monkeypox cases have occurred among MSM (
4
), who have higher prevalences of HIV infection and STIs than the general population.
However, in this analysis, the percentage of persons with monkeypox who had HIV infection
(38%) was higher than national HIV prevalence estimates for U.S. MSM (23%); this finding
was also true when comparing Monkeypox virus and HIV coinfection among Black persons
(63%), Hispanic persons (41%), and persons aged ≥55 years (59%) to overall HIV prevalences
among Black MSM (39%), Hispanic MSM (19%), and MSM aged 50–60 years (32%), respectively
(
9
). Increasing HIV prevalence among persons with monkeypox over time suggests that
monkeypox might be increasingly transmitted among networks of persons with HIV infection,
underscoring the importance of leveraging HIV and STI care and prevention delivery
systems for monkeypox vaccination and prevention efforts.
†††
Consideration should be given to prioritizing persons with HIV infection and STIs
for vaccination and other prevention efforts. HIV and STI screening and other recommended
preventive care
§§§
should be routinely offered to persons evaluated for monkeypox, with linkage to HIV
care or HIV PrEP, as appropriate.
The proportion of persons with Monkeypox virus and HIV coinfection who received HIV
care (94%) exceeded the overall percentage of persons with diagnosed HIV infection
who received care in 2020 (74%) (
8
). Approximately two thirds of persons with monkeypox without HIV infection for whom
data were available reported HIV PrEP use, whereas nationally, an estimated 25% of
eligible persons received an HIV PrEP prescription in 2020 (
8
). Moreover, 41% of persons with monkeypox had received a diagnosis of another reportable
STI in the preceding year. These findings suggest that reported monkeypox cases are
occurring among persons with recent access to HIV and sexual health services. Referral
bias might partially explain these findings, as persons with monkeypox signs and symptoms
who have established connections with HIV or sexual health providers might be more
likely to seek care (
2
), and these providers might be more likely to recognize and test for Monkeypox virus.
Monkeypox signs and symptoms might have led persons with HIV infection who have not
been in HIV care to reengage in care. Persons with monkeypox signs and symptoms who
are not engaged in routine HIV or sexual health care, or who experience milder signs
and symptoms, might be less likely to have their Monkeypox virus infection diagnosed.
To ensure appropriate diagnosis and treatment, it is important that health care providers
who do not specialize in HIV or sexual health become familiar with the clinical guidance
for monkeypox diagnosis and treatment.
¶¶¶
The higher prevalence of rectal signs and symptoms among persons with HIV infection
could be related to differences in site of exposure, increased biologic susceptibility,
or other factors. Rectal signs and symptoms did not vary by HIV immune status (CD4
count <350/μL versus ≥350 μL), supporting differences in site of exposure as a likely
explanation. In a prospective cohort in Spain, MSM with monkeypox who engaged in receptive
anal sex were more likely to report proctitis and systemic signs and symptoms preceding
rash (
3
). When evaluating patients with rectal signs and symptoms, care providers should
consider monkeypox and the possibility of concurrent rectal STIs. Understanding whether
rectal signs and symptoms can precede rash onset or occur when rash is absent or unrecognized
(because of anatomic site or small number of lesions) will help inform guidance for
Monkeypox virus testing and new diagnostic approaches.
Limited data suggest that persons with HIV infection, particularly those with low
CD4 counts or without HIV viral suppression, were more commonly hospitalized during
their monkeypox illness than were persons without HIV infection. However, because
data on reason for hospitalization are incomplete, it is not known whether this represents
more severe monkeypox illness. Ongoing monitoring of outcomes of monkeypox by HIV
infection status is important (
7
).
The findings in this report are subject to at least five limitations. First, this
analysis was limited to diagnosed and reported monkeypox cases in eight jurisdictions
and might not be generalizable to all U.S. monkeypox cases. Second, incomplete data
on clinical signs and symptoms and hospitalization might affect the associations observed
by HIV infection status. Third, some persons with undiagnosed HIV infection might
have been misclassified as not having HIV, which could reduce differences in outcomes
by HIV infection status. Fourth, local matching might have underestimated the prevalences
of HIV infection and STIs by not including diagnoses reported in other jurisdictions
or recent diagnoses. Finally, this analysis did not assess the relative contribution
of structural, social, behavioral, or biologic factors to higher HIV infection and
STI prevalences among persons with monkeypox. Further studies could improve understanding
of such factors, monkeypox outcomes, and the impact of vaccination and treatment.
Public health efforts should continue to ensure equitable access to monkeypox screening,
prevention, and treatment, particularly among MSM. It is important that systems for
delivering HIV and STI care and prevention be leveraged for monkeypox evaluation,
vaccination and other prevention interventions, and treatment (
10
). Data on diagnosis of HIV infections and STIs in close temporal association to monkeypox
diagnosis reinforce the importance of offering recommended testing, prevention, and
treatment services for HIV, STIs, and other syndemic conditions to MSM and other persons
evaluated for monkeypox.**** Routine matching of monkeypox, HIV, and STI surveillance
data to monitor trends and clinical characteristics of persons with coinfections can
further inform public health interventions.
Summary
What is already known about this topic?
In the current global monkeypox outbreak, HIV infection and sexually transmitted infections
(STIs) are highly prevalent among persons with monkeypox.
What is added by this report?
Among 1,969 persons with monkeypox in eight U.S. jurisdictions, 38% had HIV infection,
and 41% had an STI in the preceding year. Among persons with monkeypox, hospitalization
was more common among persons with HIV infection than persons without HIV infection.
What are the implications for public health practice?
It is important to leverage systems for delivering HIV and STI care and prevention
and prioritize persons with HIV infection and STIs for vaccination. Screening for
HIV and other STIs and other preventive care should be considered for persons evaluated
for monkeypox, with HIV care and HIV preexposure prophylaxis offered to eligible persons.