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      Comparison of Spontaneous Growth Hormone Secretion during Daytime and Sleep in Children with Short Stature


      Hormone Research in Paediatrics

      S. Karger AG

      Growth hormone secretion, circadian, Pharmacological tests

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          The authors compared diurnal growth hormone (GH) secretion with GH secretion during sleep in 24 children with delayed growth. In group I (children with normal response to provocative tests), the level of daytime secretion was lower than that of nocturnal secretion. In 3 of 9 cases, daytime secretion was abnormal, whereas nocturnal secretion was normal. In 2 cases, both diurnal and nocturnal secretion were abnormal, but response to provocative stimuli was normal. In group II (children with a false partial GH deficiency, i.e. with inadequate response to provocative tests, GH peak < 11 ng/ml and normal nocturnal secretion), the results were comparable with those of group I, with extremely low diurnal secretion in 6 of 9 cases. In group III (children presenting true partial GH deficiency, i.e. GH < 11 ng/ml in response to provocative tests together with abnormal nocturnal secretion), both diurnal and nocturnal GH secretion were insufficient, with nonexistent diurnal secretion in 5 of 6 cases. Diurnal secretion does not seem to be a reliable indicator of 24-hour spontaneous secretion.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 22
          : 1-2
          : 17-23
          Service de Pédiatrie, Unité d’Endocrinologie, CHU Rangueil, Toulouse, France
          180067 Horm Res 1985;22:17–23
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 7
          Pediatric Endocrinology


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