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Abstract
<p class="first" id="d1132932e123">Nano- and microparticles have increasingly widespread
applications in nanomedicine,
ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles
are the most widely-applied type of particles due to their biocompatibility and biodegradability.
Here, we discuss the preparation of PLGA particles, and various modifications to tailor
particles for applications in biological systems. We highlight new preparation approaches,
including microfluidics and PRINT method, and modifications of PLGA particles resulting
in novel or responsive properties, such as Janus or upconversion particles. Finally,
we describe how the preparation methods can- and should-be adapted to tailor the properties
of particles for the desired biomedical application. Our aim is to enable researchers
who work with PLGA particles to better appreciate the effects of the selected preparation
procedure on the final properties of the particles and its biological implications.
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