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      A new general equation for retention modeling from the organic modifier content of the mobile phase

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          Summary

          A general equation is presented for modeling retention, using the organic modifier content of the mobile phase. The equation is based on the Box-Cox transform of modifier concentration. Both the semilogarithmic relationship (Soczewiński-Wachtmeister equation) and logarithmic relationship (Snyder-Soczewiński equation) are special cases of the proposed equation. The equation can be fitted easily with free software and an additional coefficient can be interpreted as closeness to the previous models. Even with strong closeness to log-log dependence, the equation still enables extrapolation to zero modifier content. A case study on nine drug-like substances is also discussed, with comparison of 14 previously proposed retention equations found in the literature.

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          Author and article information

          Journal
          1326
          121093
          Acta Chromatographica
          A Sponsored Open Access Journal on Chromatography
          Acta Chromatographica
          Akadémiai Kiadó, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
          1233-2356
          2083-5736
          1 June 2010
          : 22
          : 2
          : 267-279
          Affiliations
          [ 1 ] Chair and Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090, Lublin, Poland
          Author notes
          Article
          9
          10.1556/AChrom.22.2010.2.9
          Categories
          Original Research Papers

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