Outcome measures in the clinical evaluation of ambulatory Charcot-Marie-Tooth 1A subjects.

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Abstract

The outcome measures (OMs) in clinical trials for Charcot-Marie-Tooth disease (CMT) still represent an issue. A recent study highlighted that three additional clinical OMs, the 10-Meter Walk Test (10MWT), the 9-Hole Peg Test, and foot dorsal flexion dynamometry, further improve discrimination between severely and mildly affected patients. Another study has recently assessed the validity and reliability of the 6-Minute Walk Test (6MWT).

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Journal

Journal ID (iso-abbrev): Eur J Phys Rehabil Med

Title: European journal of physical and rehabilitation medicine

Publisher: Edizioni Minerva Medica

ISSN (Electronic): 1973-9095

ISSN (Print): 1973-9087

Publication date (Electronic): Feb 2019

Volume: 55

Issue: 1

Affiliations

[1 ] Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy - laura.mori@unige.it.

[2 ] San Martino University Hospital and Institute for Cancer Research and Care, Genoa, Italy - laura.mori@unige.it.

[3 ] Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.

[4 ] San Martino University Hospital and Institute for Cancer Research and Care, Genoa, Italy.

[5 ] Division of Biostatistics, Department of Health Science (DISSAL), University of Genoa, Genoa, Italy.

[6 ] Carlo Besta Neurological Institute for Research and Care, Milan, Italy.

[7 ] Functional Neuromotor Rehabilitation Unit, Maugeri Scientific Institutes, Telese Terme, Benevento, Italy.

[8 ] Department of Geriatrics, Neurosciences, and Orthopedics, Sacred Heart Catholic University, Rome, Italy.

[9 ] Don Carlo Gnocchi Nonprofit Organization, Milan, Italy.

[10 ] Section of Neurology, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.

[11 ] Neuromotor and Cognitive Rehabilitation Research Center, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Article

Publisher Item ID: S1973-9087.18.05111-0

DOI: 10.23736/S1973-9087.18.05111-0

PubMed ID: 29898585

SO-VID: f7a06282-b47f-4a6d-9bcb-6d3bb3b4a7ae

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