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      Integrating depression management into HIV primary care in central Malawi: the implementation of a pilot capacity building program

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          Abstract

          Background

          In Malawi, early retention in HIV care remains challenging. Depression is strongly associated with reduced anti-retroviral therapy (ART) adherence and viral suppression. Appropriate depression care for people initiating ART is likely to be supportive of early and continued engagement in the HIV care continuum. This paper aims to provide an overview of a task-shifting program that integrates depression screening and treatment into HIV care and the strategy used to evaluate this program, describes the implementation process, and discusses key challenges and lessons learned in the first phase of program implementation.

          Methods

          We are implementing a program integrating depression screening and treatment into HIV care initiation at two clinics in Lilongwe District, Malawi. The program’s effect on patients’ depression and HIV outcomes will be evaluated using a multiple baseline pre-post study. In this manuscript, we draw from our experiences as program implementers and some of the quantitative data to describe the process of implementation and key lessons learned.

          Results

          We successfully implemented the screening phase of this program at both clinics; 88.3 and 93.2% of newly diagnosed patients have been screened for depression at each clinic respectively. 25% of enrolled patients reported symptoms of mild-to-severe depression and only 6% reported symptoms of moderate-to-severe depression. Key lessons learned from the process show the importance of utilizing existing processes and infrastructure and focusing on iterative and collaborative learning. We continued to face challenges around establishing a sense of program ownership among providers, developing capacity to diagnose and manage depression, and ensuring the availability of appropriate medication. Our efforts to address these challenges provide insight into the technical and managerial support needed to prepare for, roll out, and sustain integrated models of mental health and HIV care.

          Conclusions

          This activity demonstrates how a depression screening program can successfully be integrated into HIV care within the public health system in Malawi. While this program focuses on integrating depression management into HIV care, most of the lessons learned could apply to integration of mental health into any non-psychiatric specialist setting.

          Trial registration

          ClinicalTrials.gov ID [ NCT03555669]. Retrospectively registered on 13 June 2018.

          Electronic supplementary material

          The online version of this article (10.1186/s12913-018-3388-z) contains supplementary material, which is available to authorized users.

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          Most cited references26

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          Validity of the Patient Health Questionnaire-9 for depression screening and diagnosis in East Africa.

          Depression is often underdiagnosed and undertreated in primary care settings, particularly in developing countries. This is, in part, due to challenges resulting from lack of skilled mental health workers, stigma associated with mental illness, and lack of cross-culturally validated screening instruments. We conducted this study to evaluate the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) as a screen for diagnosing major depressive disorder among adults in Ethiopia, the second most populous country in sub-Saharan Africa. A total of 926 adults attending outpatient departments in a major referral hospital in Ethiopia participated in this study. We assessed criterion validity and performance characteristics against an independent, blinded, and psychiatrist administered semi-structured Schedules for Clinical Assessment in Neuropsychiatry (SCAN) interview. Overall, the PHQ-9 items showed good internal (Cronbach's alpha=0.81) and test re-test reliability (intraclass correlation coefficient=0.92). A factor analysis confirmed a one-factor structure. Receiver Operating Characteristics (ROC) analysis showed that a PHQ-9 threshold score of 10 offered optimal discriminatory power with respect to diagnosis of major depressive disorder via the clinical interview (sensitivity=86% and specificity=67%). The PHQ-9 appears to be a reliable and valid instrument that may be used to diagnose major depressive disorders among Ethiopian adults.
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            Role of depression, stress, and trauma in HIV disease progression.

            Despite advances in HIV treatment, there continues to be great variability in the progression of this disease. This paper reviews the evidence that depression, stressful life events, and trauma account for some of the variation in HIV disease course. Longitudinal studies both before and after the advent of highly active antiretroviral therapies (HAART) are reviewed. To ensure a complete review, PubMed was searched for all English language articles from January 1990 to July 2007. We found substantial and consistent evidence that chronic depression, stressful events, and trauma may negatively affect HIV disease progression in terms of decreases in CD4 T lymphocytes, increases in viral load, and greater risk for clinical decline and mortality. More research is warranted to investigate biological and behavioral mediators of these psychoimmune relationships, and the types of interventions that might mitigate the negative health impact of chronic depression and trauma. Given the high rates of depression and past trauma in persons living with HIV/AIDS, it is important for healthcare providers to address these problems as part of standard HIV care.
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              Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study.

              The impact of depression on morbidity and mortality among women with human immunodeficiency virus (HIV) has not been examined despite the fact that women with HIV have substantially higher rates of depression than their male counterparts. To determine the association of depressive symptoms with HIV-related mortality and decline in CD4 lymphocyte counts among women with HIV. The HIV Epidemiologic Research Study, a prospective, longitudinal cohort study conducted from April 1993 through January 1995, with follow-up through March 2000. Four academic medical centers in Baltimore, Md; Bronx, NY; Providence, RI; and Detroit, Mich. A total of 765 HIV-seropositive women aged 16 to 55 years. HIV-related mortality and CD4 cell count slope decline over a maximum of 7 years, compared among women with limited or no depressive symptoms, intermittent depressive symptoms, or chronic depressive symptoms, as measured using the self-report Center for Epidemiologic Studies Depression Scale. In multivariate analyses controlling for clinical, treatment, and other factors, women with chronic depressive symptoms were 2 times more likely to die than women with limited or no depressive symptoms (relative risk [RR], 2.0; 95% confidence interval [CI], 1.0-3.8). Among women with CD4 cell counts of less than 200 x 10(6)/L, HIV-related mortality rates were 54% for those with chronic depressive symptoms (RR, 4.3; 95% CI, 1.6-11.6) and 48% for those with intermittent depressive symptoms (RR, 3.5; 95% CI, 1.1-10.5) compared with 21% for those with limited or no depressive symptoms. Chronic depressive symptoms were also associated with significantly greater decline in CD4 cell counts after controlling for other variables in the model, especially among women with baseline CD4 cell counts of less than 500 x 10(6)/L and baseline viral load greater than 10 000 copies/microL. Our results indicate that depressive symptoms among women with HIV are associated with HIV disease progression, controlling for clinical, substance use, and sociodemographic characteristics. These results highlight the importance of adequate diagnosis and treatment of depression among women with HIV. Further research is needed to determine if treatment of depression can not only enhance the mental health of women with HIV but also impede disease progression and mortality.
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                Author and article information

                Contributors
                mphatsoudedi@yahoo.co.uk
                stocktonmelissa@gmail.com
                kkulisewa@yahoo.com
                mina_hosseinipour@med.unc.edu
                bradley_gaynes@med.unc.edu
                smphonda@unclilongwe.org
                b_mwagomba@lighthouse.org.mw
                amazenga@tingathe.org
                bpence@unc.edu
                Journal
                BMC Health Serv Res
                BMC Health Serv Res
                BMC Health Services Research
                BioMed Central (London )
                1472-6963
                31 July 2018
                31 July 2018
                2018
                : 18
                : 593
                Affiliations
                [1 ]GRID grid.415722.7, NCDs & Mental Health Unit, Ministry of Health, , Ministry of Health, ; P. O. Box 30377 Capital City, Lilongwe 3, Malawi
                [2 ]ISNI 0000000122483208, GRID grid.10698.36, Epidemiology Department, , University of North Carolina at Chapel Hill Gillings School of Global Public Health, ; 135 Dauer Dr, Chapel Hill, NC 27599 USA
                [3 ]ISNI 0000 0004 0521 7778, GRID grid.414941.d, Ministry of Health, , Kamuzu Central Hospital and Bwaila Psychiatric Hospital, ; Private Bag, 149 Lilongwe, Malawi
                [4 ]University of North Carolina Project-Malawi, Tidziwe Centre, Private Bag, A-104 Lilongwe, Malawi
                [5 ]ISNI 0000000122483208, GRID grid.10698.36, Department of Psychiatry, , University of North Carolina at Chapel Hill School of Medicine, ; 333 S Columbia St, Chapel Hill, NC 27516 USA
                [6 ]ISNI 0000 0004 0521 7778, GRID grid.414941.d, Lighthouse Trust, , Kamuzu Central Hospital, ; P.O. Box 106, Lilongwe, Malawi
                [7 ]ISNI 0000 0004 0521 7778, GRID grid.414941.d, Baylor College of Medicine Abbott Fund Children’s Clinical Centre of Excellence, , Kamuzu Central Hospital, ; Private Bag, B-397 Lilongwe, Malawi
                Author information
                http://orcid.org/0000-0002-0737-7180
                Article
                3388
                10.1186/s12913-018-3388-z
                6069990
                30064418
                f86316d4-61c7-4205-a89b-9c61e6852d81
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 7 May 2018
                : 12 July 2018
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100000200, United States Agency for International Development;
                Award ID: AID-OAA-A-14-00060
                Award Recipient :
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2018

                Health & Social care
                hiv/aids,mental health,depression,sub-saharan africa,malawi,integration,service delivery,implementation science

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