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      • Record: found
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      Effects of Danchai formula on regulation of immunologic function

      research-article
      Author(s): 1 , *
      Editor(s):
      Publication date (Electronic):
      Journal: Traditional Medicine Research
      Publisher: TMR Editorial Board
      Keywords: Danchai formula, Excessive immune response, Immune rejection

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          Abstract

          Highlights

          Danchai formula can be used to treat excessive immune response-related diseases, including immune rejection after organ transplantation, autoimmune diseases, and hypersensitivity.

          Editor’s Summary

          Danchai formula was obtained from Danzhixiaoyao powder, which was first recorded in Neikezhaiyao in the Ming Dynasty of China (1368 A.D. - 1644 A.D.) and used to disperse stagnated liver Qi and clear heat, as well as invigorate the spleen and nourish the blood.

          Abstract

          The traditional formula of Danchai was provided by associate professor Dan Chen of Tianjin Medical University, which consisted of Chaihu ( Radix Bupleuri) 9 g, Baishao ( Radix Paeoniae Alba) 9 g, Yujin ( Radix Curcumae) 30 g, Mudanpi ( Cortex moutan Radicis) 9 g, and Gancao ( Radix glycyrrhizae) 6 g. After soaking in water for 20 min, the herbs were decocted with medium heat to boiling and for 15 min with low heat. The liquid was poured out and decocted again by adding water. The decoction is mixed and consumed orally 30 min after meals, twice per day. Danchai formula can be used to treat excessive immune response-related diseases, including immune rejection after organ transplantation, autoimmune diseases, and hypersensitivity.

          Most cited references15

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          Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice.

          Long-Long Xu, Wenwei Yin, Rui Sun … (2014)
          The liver is considered as a unique lymphoid organ favoring the induction of immune tolerance, rather than immunity. Biologists and clinicians alike have a long-standing interest in how the liver induces systemic immune tolerance, but the mechanism has not yet been well elucidated. Here, we employed hepatitis B virus (HBV)-carrier mice generated by hydrodynamically injecting phosphor-adeno-associated virus/HBV1.2 plasmid as a model for adult chronic HBV infection, which we found were unable to respond to hepatitis B surface antigen vaccination. Humoral tolerance induced in HBV-carrier mice could be transferred into Rag1(-/-) mice, because anti-HBV immunity in immunologically reconstituted Rag1(-/-) mice was inhibited by adoptive transfer of splenocytes from HBV-carrier mice. Humoral tolerance needed at least 7 days for induction and persisted to 3 months after a single HBV plasmid injection. Kupffer cell (KC) depletion or interleukin (IL-10) deficiency broke this humoral tolerance, and exogenous injection of IL-10 could effectively induce this tolerance.
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            Immunoregulatory effects of glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4(+)CD25(+)Foxp3+ regulatory T cells in ovalbumin-sensitized mice.

            Zhanqiang Ma, Lin Liao, C. Ma … (2013)
            Glycyrrhizic acid (GA) is the main bioactive ingredient of licorice (Glycyrrhiza glabra), and has been found to be associated with multiple therapeutic properties. In this study, we investigated immunoregulatory effects of glycyrrhizic acid on anti-asthmatic effects and underlying mechanisms. Asthma model was established by ovalbumin-induced. A total of 60 mice were randomly assigned to six experimental groups: control, model, dexamethasone (2 mg/kg) and GA (10 mg/kg, 20 mg/kg, 40 mg/kg). Airway resistance (Raw) were measured by the forced oscillation technique, histological studies were evaluated by The hematoxylin and eosin (HE) staining, Th1/Th2 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay (ELISA), and CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) was evaluated by Flow Cytometry (FCM), the forkhead/winged helix transcription factor (Foxp3) was evaluated by western blotting. Our study demonstrated that, compared with model group, GA inhibited OVA-induced increases in Raw and eosinophil count; interleukin (IL)-4, IL-5, IL-13 levels were recovered in bronchoalveolar lavage fluid compared; increased IFN-γ level in bronchoalveolar lavage fluid; histological studies demonstrated that GA substantially inhibited OVA-induced eosinophilia in lung tissue and airway tissue compared with model group. Flow cytometry studies demonstrated that GA substantially enhanced Tregs compared with model group. These findings suggest that GA may effectively ameliorate the progression of asthma and could be used as a therapy for patients with allergic asthma. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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              Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis.

              Yang Sun, Tian-Tian Cai, Xiao-Bin Zhou … (2009)
              In the present study, we aimed at examining the immunosuppressive activity of saikosaponin a, a triterpene saponin derived from Bupleurum falcatum L. (Umbelliferae), and the underlying mechanisms. Saikosaponin a significantly inhibited the proliferation and activation of T cells activated by concanavalin A (Con A) in a concentration-dependent manner. Additionally, it potently suppressed Con A-stimulated IL-2, IFN-gamma and TNF-alpha production in mouse T cells. Saikosaponin a also caused G0/G1 arrest of activated T cells through down-regulating the protein levels of CDK6 and Cyclin D3 and up-regulating the protein level of p27(kip). Furthermore, the compound dose-dependently induced apoptosis of Con A-activated T cells rather than those non-activated, as determined by Annexin V/PI staining. Besides, it induced a remarkable collapse of mitochondrial membrane potential and caused significant release of cytochrome c from mitochondria to cytosol. In summary, these results suggest that the G0/G1 arrest as well as the induction of apoptosis via mitochondrial pathway are involved in the immunosuppressive activity of saikosaponin a against activated T cells. This may herald a novel approach for further studies of saikosaponin a as a candidate for the treatment of inflammatory and autoimmune diseases.
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                Author and article information

                Contributors
                Chen Dan
                Journal
                Journal ID (nlm-ta): TMR Editorial Board
                Title: Traditional Medicine Research
                Publisher: TMR Editorial Board (Jintang road, 99, Hedong district Tianjin,China, 300170 )
                ISSN (Electronic): 2413-3973
                Publication date Collection: October 2017
                Publication date (Electronic): 5 October 2017
                Volume: 2
                Issue: 4
                Pages: 198-201
                Affiliations
                [1-2413-3973-2-4-198] 1Department of Pharmacology, Basic Medical College, Tianjin Medical University, Tianjin, China.
                Author notes
                *Correspondence to: Dan Chen, Department of Pharmacology, Basic Medical College, Tianjin Medical University, Tianjin, China. E-mail: ilvcd@ 123456163.com .
                Article
                Publisher ID: 2413-3973-2-4-198
                DOI: 10.12032/TMR201708058
                SO-VID: f8e1e928-d1b1-441a-8e06-b3c8194f1d25
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

                History
                Date accepted : 20 June 2017
                Categories
                Subject: Empirical Formula Research

                ScienceOpen disciplines: Medicine,Pharmacology & Pharmaceutical medicine,Health & Social care,Complementary & Alternative medicine
                Keywords: Danchai formula,Immune rejection,Excessive immune response
                Data availability:
                ScienceOpen disciplines: Medicine, Pharmacology & Pharmaceutical medicine, Health & Social care, Complementary & Alternative medicine
                Keywords: Danchai formula, Immune rejection, Excessive immune response

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