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      Black soybean tempeh and purple sweet potato improve sperm quality in streptozotocin-induced diabetic rats

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          Abstract

          Background and Aim:

          Hyperglycemia increases advanced glycation end-product (AGE) production, and the activity of receptor for AGE (RAGE) in testis, which leads to testicular histopathological damage and infertility. This research investigated the effect of black soybean tempeh (BST), purple sweet potato (PSP), and its combination on AGE and RAGE expression and spermatozoa quality in streptozotocin (STZ)-induced diabetic rats.

          Materials and Methods:

          The rats were given high-fat diets for 5 weeks, then were injected intraperitoneally with multiple low doses of STZ (30 mg/kg body weight). Diabetes mellitus (DM) rats were divided into seven groups: DM, DM+glibenclamide, DM+BST, DM+PSP, and DM+combination of BST and PSP in ratio 1:3, 2:2, and 3:1 as C1, C2, and C3, respectively. The rats were treated for 30 days. Testicular AGE and RAGE expression and spermatozoa quality were measured.

          Results:

          The combination of BST and PSP significantly decreased AGE and RAGE expression in testicular organs and improved spermatozoa quality compared to the normal group.

          Conclusion:

          The combination of BST and PSP can be used as future alternatives to improve spermatozoa quality in DM patients.

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          Most cited references41

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          Anthocyanins: natural colorants with health-promoting properties.

          Jian-Qing He, M Giusti (2009)
          Anthocyanins are flavonoids in fruits and vegetables that render them vivid red to blue. To date, there have been more than 635 anthocyanins identified in nature, featuring six common aglycones and various types of glycosylations and acylations. Dietary consumption of anthocyanins is high compared to other flavonoids, owing to their wide distribution in plant materials. Based upon many cell-line studies, animal models, and human clinical trials, it has been suggested that anthocyanins possess anti-inflammatory and anti-carcinogenic activity, cardiovascular disease prevention, obesity control, and diabetes alleviation properties, all of which are more or less associated with their potent antioxidant property. Evidence suggests that absorption of anthocyanins occurs in the stomach and small intestine. Epithelial tissue uptake seems to be highly efficient, yet transportation into circulation, tissue distribution, and urine excretion are very limited. The bioactivity of bioavailable anthocyanins should be a focus of future research regarding their putative health-promoting effects.
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            Modeling type 2 diabetes in rats using high fat diet and streptozotocin

            Søs Skovsø (2014)
            Abstract The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the disease etiology are known, many critical questions remain to be answered before next‐generation therapeutics can be developed. In order to further elucidate the pathobiology of this disease, animal models mimicking the pathology of human type 2 diabetes are of great value. One example of a type 2 diabetes animal model is the high‐fat diet‐fed, streptozotocin (HFD/STZ)‐treated rat model. The present review first summarizes the current understanding of the metabolic profile and pathology involved in the different stages of the type 2 diabetes disease progression in humans. Second, the known characteristics of the HFD/STZ rat model are reviewed and compared with the pathophysiology of human type 2 diabetes. Next, the suitability of the HFD/STZ model as a model of type 2 diabetes with a focus on identifying critical caveats and unanswered questions about the model is discussed. The improved understanding of refined animal models will hopefully lead to more relevant preclinical studies and development of improved therapeutics for diabetes. Depending on the amount of residual functional β‐cells mass, the HFD/STZ rat model might be a suitable animal model of the final stage of type 2 diabetes.
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              The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis

              Guo-Lian Ding, Ye Liu, Miao-E Liu … (2015)
              The effects of diabetes mellitus include long-term damages, dysfunctions, and failures of various organs. An important complication of diabetes is the disturbance in the male reproductive system. Glucose metabolism is an important event in spermatogenesis. Moreover, glucose metabolism is also important for maintaining basic cell activity, as well as specific functions, such as motility and fertilization ability in mature sperm. Diabetic disease and experimentally induced diabetes both demonstrated that either type 1 diabetes or type 2 diabetes could have detrimental effects on male fertility, especially on sperm quality, such as sperm motility, sperm DNA integrity, and ingredients of seminal plasma. Epigenetic modifications are essential during spermatogenesis. The epigenetic regulation represents chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and the higher-order chromatin reorganization and noncoding RNAs. If spermatogenesis is affected during the critical developmental window, embryonic gonadal development, and germline differentiation, environmentally-induced epigenetic modifications may become permanent in the germ line epigenome and have a potential impact on subsequent generations through epigenetic transgenerational inheritance. Diabetes may influence the epigenetic modification during sperm spermatogenesis and that these epigenetic dysregulation may be inherited through the male germ line and passed onto more than one generation, which in turn may increase the risk of diabetes in offspring.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Vet World
                Journal ID (iso-abbrev): Vet World
                Title: Veterinary World
                Publisher: Veterinary World (India )
                ISSN (Print): 0972-8988
                ISSN (Electronic): 2231-0916
                Publication date (Print): November 2020
                Publication date (Electronic): 27 November 2020
                Volume: 13
                Issue: 11
                Pages: 2534-2540
                Affiliations
                [1 ]Department of Biology, Faculty of Mathematics and Science, Universitas Negeri Malang, Jalan Semarang no. 5, 65145, Malang, East Java, Indonesia
                [2 ]Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia
                Author notes
                Article
                Publisher ID: Vetworld-13-2534
                DOI: 10.14202/vetworld.2020.2534-2540
                PMC ID: 7750209
                SO-VID: f9945a52-a260-4938-9cf7-13ca395c44ae
                Copyright © Copyright: © Gofur, et al.
                License:

                Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 19 June 2020
                Date accepted : 19 October 2020
                Categories
                Subject: Research Article

                Keywords: antioxidant,black soybean tempeh,purple sweet potato,spermatozoa
                Data availability:
                Keywords: antioxidant, black soybean tempeh, purple sweet potato, spermatozoa

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