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      Comparative Hepatology: A journal for all hepatologists with immediate Open Access to quality peer-reviewed research

      editorial
      1 , , 2 , 3
      Comparative Hepatology
      BioMed Central

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          Abstract

          What is Comparative Hepatology? Comparative Hepatology is an Open Access, peer-reviewed online journal for liver-oriented research, publishing basic and applied studies, in biology, veterinary and human medicine. The journal is published by BioMed Central. The journal is a valuable reference forum for publication of quality original research on the normal or disrupted anatomy and physiology of the liver, including any of its supracellular, cellular or subcellular components. It considers articles that deal descriptively or experimentally with the liver. It also welcomes pathobiology studies. Translational research reports are encouraged and purely clinical hepatology is considered especially when it bears new insights on the structure and function of the liver. Multidisciplinary approaches (involving diverse expertise or organs) are welcomed, and articles are acceptable, subject to peer review, as long as the liver is a major focus of the study. Comparative Hepatology is a unique journal in its field, allowing and encouraging publication of data from liver research spanning a wide range of scientific interests and species, as long as the results and conclusions are original and scientifically justified. The journal naturally brings together hepatologists with different views, expertise and particular interests. Peer review policy Publication of articles is dependent only on scientific validity, as judged by Editors and peer reviewers. At least two experts will review submitted manuscripts. Key issues for peer reviewers are the methodological rigour, whether the work has flaws that should preclude publication, and whether the results are original and adequate to support the conclusions drawn. Authors are requested to suggest peer reviewers; however, the Editors can choose referees other than, or in addition to, those suggested. What Open Access really means for hepatologists? Open Access normally applies only to research articles. Comparative Hepatology however, has taken this further, by making all of its articles Open Access. Open Access changes the way in which articles are published. First, all accepted articles immediately become freely and universally accessible online, and so an author's work can be read by anyone at no cost. Second, the authors hold copyright for their work and grant anyone the right to reproduce and disseminate the article, provided that it is correctly cited and no errors are introduced [1]. Third, a copy of the full text of each article is permanently archived in an online repository separate from the journal. Comparative Hepatology articles are archived in PubMed Central [2], the US National Library of Medicine's full-text repository of life science literature, and also in repositories at the University of Potsdam [3] in Germany, at INIST [4] in France and in e-Depot [5], the National Library of the Netherlands' digital archive of all electronic publications. Article-processing charges and waivers Article-processing charges (APCs) are needed to allow continued Open Access to Comparative Hepatology articles. Authors are asked to pay the equivalent to US$525 if their article is accepted for publication. No charge is made for articles that are rejected after peer review. The Editor-in-Chief will consider waiver requests on a case-by-case basis. Discounts equivalent to US$50 are available if authors submit their manuscript with references handled and formatted with recommended bibliographic software (Endnote 5/6 or Reference Manager 10). Authors can circumvent the charge by getting their institution to become a 'member' of BioMed Central, whereby the annual membership fee covers the APCs for all authors at that institution for that year. This programme has been a success, and the number of members continues to increase, and include to this date more than 395 members in 32 countries. Current members include, for example, the NHS England, the World Health Organization, the US National Institutes of Health, Harvard, Princeton and Yale universities, and all UK universities [6]. Funding agencies have also realized the importance of Open Access publishing and have specified that their grants may be used directly to pay APCs [7]. A glance at our first year of publication Launched in late August 2002, the journal has received submissions from Africa, Asia, Europe, and United States of America. From this pool, several manuscripts were found acceptable and were published. The articles fulfilled the journal's "comparative" aim, covering a wide range of species within a broad scope. Reviewers were chosen with utmost care. Our rejection rate was 29%. At least six indexed articles cited Comparative Hepatology articles, as currently seen in ISI Web of KnowledgeSM. The Proceedings of the 11th International Symposium on the Cells of the Hepatic Sinusoids and their Relation to Other Cells, comprising 58 articles, were published as a supplement (January 14th). There was a delay in having them published because the manuscripts (including images) were not initially prepared for online publishing; a key aspect in electronic publishing. A relevant aspect was revealed by the fact that many errors in references would most likely pass unnoticed in a printed version – online linking of the majority of references to their PubMed citations avoided such errors appearing. Speeding up publication, with a little help from the authors From submission to publication in provisional but fully peer reviewed form, the shortest publication schedule for an original research article published in this journal was 2 months and 9 days [8]. Such a fast schedule, or shorter, is what authors might expect when strictly adhering to our simple submission instructions, and providing fast feedback to the Editorial requests. As pointed out by Wheatley and Grynszpan [9], for exceptionally good articles the mechanism is in place to achieve remarkable times from submission to publication; being technically possible to publish within a day. Why choose Comparative Hepatology to publish your research? To put it simply, there are good reasons for publishing in Comparative Hepatology, namely: • electronic publishing with immediate free access for everybody • unlimited space, with the possibility to publish additional material • color illustrations at no extra cost • fast and through peer review • articles published immediately upon acceptance and soon after listed in PubMed • authors and their peers are free to print out copies of their article, email it to colleagues, and post it on the web because of the BioMed Central copyright and license agreement. In the coming years, we expect a steady increase in the number of submissions and publications. Authors and their Institutions have been increasingly supportive of the Open Access model as a viable and quite efficient way to disseminate the results of quality scientific research. The Institute of Scientific Information has already given impact factors for several BioMed Central journals. Comparative Hepatology will surely follow this way, supporting at the same time all BioMed Central efforts in the development and implementation of electronic tools that may allow authors to track and know the dissemination and impact of their particular Open Access article. Why not submit your next liver-oriented research article to Comparative Hepatology? This option will simply assure that, if published, your work would be disseminated to the widest possible audience, given that there are no barriers to access. It has been shown that free online articles are more highly cited because of their easier availability [10], thus promoting their real individual impact among peers and society. To speed up the process, manuscripts are submitted electronically, using the online submission system. Full details of how to submit a manuscript are given in our instructions for authors. Join or keep supporting the new era of electronic publishing and Open Access in hepatology.

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          Most cited references3

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          Free online availability substantially increases a paper's impact.

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            Liver sinusoidal endothelial cells represents an important blood clearance system in pigs

            Background Numerous studies in rats and a few other mammalian species, including man, have shown that the sinusoidal cells constitute an important part of liver function. In the pig, however, which is frequently used in studies on liver transplantation and liver failure models, our knowledge about the function of hepatic sinusoidal cells is scarce. We have explored the scavenger function of pig liver sinusoidal endothelial cells (LSEC), a cell type that in other mammals performs vital elimination of an array of waste macromolecules from the circulation. Results 125I-macromolecules known to be cleared in the rat via the scavenger and mannose receptors were rapidly removed from the pig circulation, 50% of the injected dose being removed within the first 2–5 min following injection. Fluorescently labeled microbeads (2 μm in diameter) used to probe phagocytosis accumulated in Kupffer cells only, whereas fluorescently labeled soluble macromolecular ligands for the mannose and scavenger receptors were sequestered only by LSEC. Desmin-positive stellate cells accumulated no probes. Isolation of liver cells using collagenase perfusion through the portal vein, followed by various centrifugation protocols to separate the different liver cell populations yielded 280 × 107 (range 50–890 × 107) sinusoidal cells per liver (weight of liver 237.1 g (sd 43.6)). Use of specific anti-Kupffer cell- and anti-desmin antibodies, combined with endocytosis of fluorescently labeled macromolecular soluble ligands indicated that the LSEC fraction contained 62 × 107 (sd 12 × 107) purified LSEC. Cultured LSEC avidly endocytosed ligands for the mannose and scavenger receptors. Conclusions We show here for the first time that pig LSEC, similar to what has been found earlier in rat LSEC, represent an effective scavenger system for removal of macromolecular waste products from the circulation.
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              Can we speed up the online publishing process? And who will pay for it, anyway?

              Some current bottlenecks CCI is now getting some excellent papers. Part of Biomed Central's policy - to which we fully subscribe - is that papers accepted following peer reviewing and revision to ensure the highest quality shall be published on our website as quickly as possible, with free access worldwide. A turnaround time of 50 days should now be well within the norm, and may well fall to nearer 30-35 days. For exceptionally good papers, this time delay may be very much shorter (technically it is possible to publish within a day), and the mechanism is in place to achieve these remarkable times. However, to date, CCI simply cannot boast an improved turnaround time. Apart from some gremlins that had to be sorted out in the publishing process for niche journals, delay between submission and publication of good papers sadly remains much as for "conventional" journals. The two main sticking points are (a) peer reviewing and (b) author resubmission. Taking the first, the rapid way in which a submitted paper goes straight to a private website means that we direct referees attention to it almost instantly by emailing them the private URL details. This is still a novelty for some reviewers, who no longer have a hardcopy of the manuscript on their desk as a constant reminder of the request made upon them. We hope that, as everyone becomes more accustomed to handling email, reviewers will oblige us by acknowledging receipt of the URL message and sending in reports within 7 to 10 days. On the other matter, it is not always clear to authors where their responsibility lies in on-line publishing. The most important thing is for an author to realise that he or she is fully responsible for loading the manuscript in its entirety, in complete conformity with the requirements laid down by BMC, especially in file formats and style. Not only once, but at times when the article is altered for any reason, it is the author's responsibility to resubmit the new version without delay. We have no mechanism at present for reminding authors that we await a new figure, table, or revised text file. We simply believe that most changes that need to be made to a manuscript can be done very quickly, and that authors in their own interest will update their files at the earliest opportunity; procrastination simply delays progress. It is of little concern how many times this exercise is done because we always follow the latest version, although we rather it was done just prior to final acceptance than at every occasion when a comma is added or an excess space deleted. Submission charges The Varmus Principle is that primary research papers should be published online so that they become immediately and freely accessible to readers. Publication has its costs, especially where extensive reviewing, editing and revision has to be done to ensure that quality is not compromised. But who pays? This issue has not been satisfactorily resolved. No firm decision could have been taken, because the ways in which readers, writers, institutions, libraries and funding agencies would react to either the public or the private sector carrying out on-line publishing were unknowns until we got the process firmly established. An income stream is clearly necessary to sustain the operation, which we now see as unlikely to be adequately generated by advertising on our pages, or similar ploys. It is recognised in all quarters, however, that the "product" of research is a valid, creditable publication. The final step, after all the research and writing up has been done, is for the product to become readily available (the prime function of any scientific or medical journal) to the scientific and medical fraternities. Thus its production should be seen as legitimate expenditure that comes from the source of funding of the research that supported the research in the first instance. Indeed, costing ought to be automatically included in any grant application, although a few agencies are still clearly unhappy that about this. An alternative is that access to online websites is made readily available from Institutions of Higher Learning to their employees and students. Many institutions have therefore become affiliated to the online publishing house, paying a subscription that allows any associate working under their institutional umbrella to publish his or her work without any further fee. For those remaining outside these institutions, there will be a flat submission fee of 500 US dollars. Where authors clearly find this difficult for economic reasons (as in third world countries)*, the fee can be referred, reduced or waived, but where people can pay, we hope that this once-only fee per manuscript will be seen as an assured way of having the privilege of publishing so that all your colleagues can get free and immediate access to their work on their side, and that we might be sufficiently well reimbursed to continue in the future to provide this service to science. Sponsorship might lighten this load off CCI, but we have to wait to see whether philanthropy enters the online publishing scene in the way it has supported libraries and other facilities of higher learning in the past. To read more about this, please go to Cancer Cell International's FAQ's pages where the introduction and reasons for submission charges are discussed . * Please take careful note that there are ways in which less privileged countries (a total of about 67) can gain subsidies to assist in publication costs, provided the Varmus principle is upheld. The Open Society Institute (OSI) in Budapest controls funds made available through the generosity of the Soros Foundation, which allows authors from countries such as Nigeria, Vietnam, Bulgaria, and 64 others to apply for help in getting manuscripts published. We ask you to direct your attention to the controller of this funding agency in Budapest, Ms Melissa Hagemann at the following email address: mhagemann@sorosny.org We ourselves are in negotiation with OSI, and through them the process may be simplified by their providing direct cover to us for the submission fees of manuscripts emanating from countries on their list.
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                Author and article information

                Journal
                Comp Hepatol
                Comparative Hepatology
                BioMed Central (London )
                1476-5926
                2004
                12 February 2004
                : 3
                : 1
                Affiliations
                [1 ]Laboratory of Histology and Embryology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar – ICBAS, University of Porto, Lg. Prof. Abel Salazar n° 2, 4099-003 Porto, Portugal
                [2 ]Duke University, Nicholas School of the Environment and Earth Sciences, Division of Environmental Sciences and Policy, A-333 LSRC, Science Drive, Box 90328 Durham, North Carolina 27708-0328, United States
                [3 ]Irisweg 16, 3140 Keerbergen, Belgium
                Article
                1476-5926-3-1
                10.1186/1476-5926-3-1
                375541
                14962350
                fa64ada0-09f6-4b05-879b-5e790b1f3785
                Copyright © 2004 Rocha et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
                History
                : 20 January 2004
                : 12 February 2004
                Categories
                Editorial

                Gastroenterology & Hepatology
                Gastroenterology & Hepatology

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