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      Mefenamic acid-induced bilateral transient myopia, secondary angle closure glaucoma and choroidal detachment

      case-report

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          Abstract

          Drug-induced secondary angle closure is quite common and in the majority of cases simply stopping the medication leads to rapid reversal of the condition and resolution of glaucoma. We describe here a patient who presented with secondary angle closure glaucoma and myopia following mefenamic acid ingestion which was managed successfully by stopping the medication, symptomatic treatment and reassurance.

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          Topiramate-associated acute, bilateral, secondary angle-closure glaucoma.

          F T Fraunfelder, Edwin U Keates (2003)
          To evaluate spontaneous reports of ocular side effects associated with topiramate use. Retrospective case series. One hundred fifteen case reports, primarily of a specific ocular syndrome (acute secondary angle-closure glaucoma), were collected from spontaneous reporting systems: the Drug Safety section of Ortho-McNeil Pharmaceuticals, Inc. (Raritan, NJ), the Food and Drug Administration (Rockville, MD), the World Health Organization (Uppsala, Sweden), the National Registry of Drug-Induced Side Effects (Casey Eye Institute, Oregon Health & Science University, Portland, Oregon), and the world literature. The data were evaluated using the World Health Organization Causality Assessment Guide to the certainty of a suspected adverse drug reaction. Eighty-six cases of acute-onset glaucoma (83 bilateral and 3 unilateral), 17 cases of acute bilateral myopia (up to 8.75 diopters), 9 cases of suprachoroidal effusions, 3 cases of periorbital edema, and 4 cases of scleritis were reported. In those cases for which management was reported, 38% had laser or surgical peripheral iridectomy (21 cases). In the "certain" category of the World Health Organization classification system, the following are caused by topiramate therapy: abnormal vision, acute secondary angle-closure glaucoma, acute myopia, and suprachoroidal effusions. All findings are reversible if recognized early and if the drug is discontinued. The first presenting symptom of acute secondary angle-closure glaucoma in many patients was blurring of vision. Peripheral iridectomy is ineffective for this type of angle-closure glaucoma.
          Article 0 comments Cited 53 times – based on 0 reviews     Review now
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            Drug-induced ciliary body oedema: a new theory.

            Marguerite Schipper, P. Krieg (1995)
            Drug-induced oedema of the ciliary body is rare, and occurs predominantly following exposure to sulphonamides. In a 31-year-old patient in her 37th week of pregnancy, we observed reversible myopia of -4.75 dioptres following the ingestion of chlorthalidone. In a second case report we describe, in a 61-year-old patient suffering from aspirin-sensitive asthma, recurrent ciliary body oedema with a marked spastic component which was triggered by the medications acetazolamide, dipivefrine and pilocarpine. We explain oedema of the ciliary body on the basis of the eicosanoids. We believe that the oedema is caused mainly by prostaglandins and that leucotrienes are predominantly responsible for the spastic component. We postulate a drug-induced elevation in eicosanoid concentrations, as well as certain interrelationships between ciliary body oedema and aspirin-sensitive asthma.
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              Ciliochoroidal effusion syndrome induced by sulfa derivatives.

              Naohiro Ikeda, Tomohiro Ikeda, Jason Nagata … (2002)
              Article 0 comments Cited 14 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Indian J Ophthalmol
                Journal ID (publisher-id): IJO
                Title: Indian Journal of Ophthalmology
                Publisher: Medknow Publications (India )
                ISSN (Print): 0301-4738
                ISSN (Electronic): 1998-3689
                Publication date (Print): Sep-Oct 2009
                Volume: 57
                Issue: 5
                Pages: 398-400
                Affiliations
                Glaucoma Services, Aravind Eye Hospital, Avinashi Road, Coimbatore-641014, India
                Author notes
                Correspondence to: Ganesh V. Raman, Glaucoma Services, Aravind Eye Hospital, Avinashi Road, Coimbatore - 641 014, India. E-mail: ganeshvr75@ 123456gmail.com
                Article
                Publisher ID: IJO-57-398
                DOI: 10.4103/0301-4738.55066
                PMC ID: 2804134
                PubMed ID: 19700884
                SO-VID: facdd08d-ce62-4245-8841-86cf8d41a7e4
                Copyright © © Indian Journal of Ophthalmology
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 20 December 2007
                Date accepted : 09 October 2008
                Categories
                Subject: Brief Communications

                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: mefenamic acid,secondary angle closure glaucoma
                Data availability:
                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: mefenamic acid, secondary angle closure glaucoma

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