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      An endometrial receptivity scoring system basing on the endometrial thickness, volume, echo, peristalsis, and blood flow evaluated by ultrasonography

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          Abstract

          Background

          Establishing a successful pregnancy depends on the endometrium and the embryo. It is estimated that suboptimal endometrial receptivity account for one-third of implantation failures. Despite the indepth understanding of the processes associated with embryo-endometrial cross-talk, little progress has been achieved for diagnosis and treatments for suboptimal endometrial receptivity.

          Methods

          This retrospective study included women undergoing their first frozen-thawed embryo transfer (FET) cycles at our reproductive medicine center from March 2021 to August 2021. Transvaginal three-dimensional (3D) ultrasound was performed in the morning on the day of embryo transfer for all the thawed embryo transfer patients, to evaluate endometrial receptivity, including endometrial thickness, echogenicity, volume, movement and blood flow.

          Results

          A total number of 562 patients of FET with 315 pregnancies (56.0%) was analyzed. It was found that only the echo of the endometrial central line was different between the pregnant group and non-pregnant group. Other parameters, such as endometrial thickness, volume, endometrial peristalsis, or the endometrial blood flow were not statistically different between the two groups. Then, according to the relationship between the different groups and the clinical pregnancy rate, a score of 0 to 2 was respectively scored. The sum of the scores for the six items was the patient’s endometrial receptivity score. It showed that the clinical pregnancy rate increased as the endometrial receptivity score increased, and when the receptivity score reaches at least 5, the clinical pregnancy rate is significantly improved (63.7% versus 49.5%, P=0.001).

          Conclusion

          We developed an endometrial receptivity scoring system and demonstrated its validity. It may aid clinicians in choosing the useful marker in clinical practice and for informing further research.

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          Most cited references37

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          The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting.

          Many variations in oocyte and embryo grading make inter-laboratory comparisons extremely difficult. This paper reports the proceedings of an international consensus meeting on oocyte and embryo morphology assessment. Background presentations about current practice were given. The expert panel developed a set of consensus points to define the minimum criteria for oocyte and embryo morphology assessment. It is expected that the definition of common terminology and standardization of laboratory practice related to embryo morphology assessment will result in more effective comparisons of treatment outcomes. This document is intended to be referenced as a global consensus to allow standardized reporting of the minimum data set required for the accurate description of embryo development.
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            The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.

            To demonstrate the clinical value of the endometrial receptivity array (ERA) in patients with repeated implantation failure (RIF), for guiding their personalized embryo transfer (pET) as a novel therapeutic strategy.
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              • Record: found
              • Abstract: not found
              • Article: not found

              Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis

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                Author and article information

                Contributors
                Journal
                Front Endocrinol (Lausanne)
                Front Endocrinol (Lausanne)
                Front. Endocrinol.
                Frontiers in Endocrinology
                Frontiers Media S.A.
                1664-2392
                09 August 2022
                2022
                : 13
                : 907874
                Affiliations
                [1] 1 Center for Reproductive Medicine, Peking University Shenzhen Hospital , Shenzhen, China
                [2] 2 Department of Ultrasonography, Peking University Shenzhen Hospital , Shenzhen, China
                Author notes

                Edited by: Julius Hreinsson, Sahlgrenska University Hospital, Sweden

                Reviewed by: Ahmad Mustafa Metwalley, Women’s Health Fertility Clinic, Saudi Arabia; Maryam Farid Mojtahedi, Tehran University of Medical Sciences, Iran

                *Correspondence: Wei-ping Qian, qianweipingsz@ 123456126.com

                †These authors have contributed equally to this work and share first authorship

                This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology

                Article
                10.3389/fendo.2022.907874
                9395662
                36017318
                fb43a0cd-7b09-4ebf-bd4a-0b7eda4d49e1
                Copyright © 2022 Zhang, Chen, Wang, Wang, Wen, Cao and Qian

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 30 March 2022
                : 25 July 2022
                Page count
                Figures: 3, Tables: 3, Equations: 0, References: 37, Pages: 11, Words: 5738
                Categories
                Endocrinology
                Original Research

                Endocrinology & Diabetes
                endometrial receptivity,three-dimensional ultrasound,endometrial thickness,endometrial volume,echo,endometrial peristalsis,blood flow

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