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      Is Open Access

      The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis

      research-article
      Author(s): 1 , 2 , 3 , 3 , 3 , 3 ,
      Publication date (Electronic):
      Journal: Disease Markers
      Publisher: Hindawi

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          Abstract

          Objective

          Increasing evidence has demonstrated the essential role of lncRNAs in tumorigenesis. LINC00514, a novel lncRNA, was reported to be a promoter of malignant behaviors in cancer, but in pituitary adenoma (PA), its biological functions remain unclear.

          Methods

          Herein, we measured LINC00514 expression by RT-qPCR analysis which indicated a significant elevation of LINC00514 expression in human PA tissues. Moreover, the effect of LINC00514 silencing on PA cell proliferation and invasion was, respectively, examined by CCK-8 and transwell assays.

          Results

          The results showed that LINC00514 deletion markedly inhibited PA cell proliferation and invasion. Besides, investigation on the molecular mechanisms showed that LINC00514 might function as an endogenous RNA (ceRNA) to sponge miR-28-5p and TRIM44 was mediated by LINC00514-derived miR-28-5p in PA cells. Furthermore, the AKT/mTOR signaling pathway was mediated through the LINC00514/miR-28-5p/TRIM44 axis.

          Conclusion

          To sum up, we suggested LINC00514 as a novel therapeutic target for PA treatment.

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          Most cited references35

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          Earth BioGenome Project: Sequencing life for the future of life

          Erich D. Jarvis, Gene Robinson, Warren E Johnson … (2018)
          Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort.
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            Long non-coding RNAs: Mechanism of action and functional utility

            Shakil Ahmad Bhat, Syed Ahmad, Peerzada Tajamul Mumtaz … (2016)
            Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs) are non-coding transcripts longer than 200 nucleotides. Members of the non-coding genome include microRNA (miRNA), small regulatory RNAs and other short RNAs. Most of long non-coding RNA (lncRNAs) are poorly annotated. Recent recognition about lncRNAs highlights their effects in many biological and pathological processes. LncRNAs are dysfunctional in a variety of human diseases varying from cancerous to non-cancerous diseases. Characterization of these lncRNA genes and their modes of action may allow their use for diagnosis, monitoring of progression and targeted therapies in various diseases. In this review, we summarize the functional perspectives as well as the mechanism of action of lncRNAs.
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              LncRNA CCAT1 Promotes Prostate Cancer Cell Proliferation by Interacting with DDX5 and MIR-28-5P

              Zonghao You, Chunhui Liu, Can Wang … (2019)
              Article 0 comments Cited 44 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Zhiguo Zhang:
                ORCID: https://orcid.org/0000-0002-1583-0547
                Journal
                Journal ID (nlm-ta): Dis Markers
                Journal ID (iso-abbrev): Dis Markers
                Journal ID (publisher-id): DM
                Title: Disease Markers
                Publisher: Hindawi
                ISSN (Print): 0278-0240
                ISSN (Electronic): 1875-8630
                Publication date Collection: 2022
                Publication date (Electronic): 23 September 2022
                Volume: 2022
                Electronic Location Identifier: 1889467
                Affiliations
                1Department of the Central Laboratory, The Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, China
                2Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang 712046, China
                3Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710039, China
                Author notes

                Academic Editor: Tian jiao Wang

                Author information
                https://orcid.org/0000-0002-1583-0547
                Article
                DOI: 10.1155/2022/1889467
                PMC ID: 9525750
                PubMed ID: 36193506
                SO-VID: fb6fa0a6-6687-4236-b39f-fbcbaf2c0ac3
                Copyright © Copyright © 2022 Lin Wu et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 27 July 2022
                Date revision received : 23 August 2022
                Date accepted : 24 August 2022
                Funding
                Funded by: National Natural Science Foundation of China
                Award ID: 81870892
                Categories
                Subject: Research Article

                Data availability:

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