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      Diurnal Fluctuations in Methionine-Enkephalin Levels in the Hypothalamus and Preoptic Area of the Male Rat: Effects of Pinealectomy

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          Abstract

          Methionine-enkephalin (met-enk) levels were measured at 09.30–10.30, 16.30–17.30 and 23.30–00.30 h in the anterior hypothalamus-preoptic area (AHPOA), medial basal hypothalamus (MBH), anterior, intermediate and posterior lobe of the pituitary gland of male rats. Met-enk levels in the AHPOA and MBH fluctuated significantly through a 24-hour period; from low levels at 09.30–10.30 h, met-enk in the AHPOA and MBH rose slowly in the afternoon to reach peak concentrations at 23.30–00.30 h. Pinealectomy appears to depress or shift the normally occurring increments in met-enk levels at 23.30–00.30 h in the AHPOA only. Serum testosterone (T) levels displayed an inverse relationship with the met-enk rhythm; high concentrations during the day were associated with low met-enk levels and as T levels decreased to a nadir at 23.30–00.30 h, the met-enk in the MBH and AHPOA attained peak concentrations. Daily changes in serum T levels were not affected by pinealectomy.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1982
          1982
          26 March 2008
          : 35
          : 1
          : 28-31
          Affiliations
          aDepartments of Metabolism and Reproduction, College of Veterinary Medicine, bDepartment of Animal Sciences, cDepartment of Obstetrics and Gynecology, College of Medicine, University of Florida, Gainesville, Fla., USA
          Article
          123350 Neuroendocrinology 1982;35:28–31
          10.1159/000123350
          7202129
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 4
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          Original Paper

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