Prognostic Value of 18F-FLT PET in Patients with Neuroendocrine Neoplasms: A Prospective Head-to-Head Comparison with 18F-FDG PET and Ki-67 in 100 Patients.

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Abstract

Neuroendocrine neoplasms (NENs) constitute a heterogeneous group of tumors arising in various organs and with a large span of aggressiveness and survival rates. The Ki-67 proliferation index is presently used as the key marker of prognosis, and treatment guidelines are largely based on this index. 3'-deoxy-3'-18F-fluorothymidine (18F-FLT) is a proliferation tracer for PET imaging valuable in the monitoring of disease progression and treatment response in various types of cancer. However, until now only data from 10 patients with NEN were available in the literature. The aim of the present study was to investigate 18F-FLT PET as a prognostic marker for NENs in comparison with 18F-FDG PET and Ki-67 index.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Nucl. Med.

Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Publisher: Society of Nuclear Medicine

ISSN (Electronic): 1535-5667

ISSN (Print): 0161-5505

Publication date (Electronic): Dec 2016

Volume: 57

Issue: 12

Affiliations

[1 ] Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Cophenhagen, Denmark.

[2 ] ENETS Neuroendocrine Tumor Center of Excellence, Rigshospitalet, Copenhagen, Denmark.

[3 ] Department of Surgical Gastroenterology and Department of Clinical Endocrinology, Rigshospitalet, Copenhagen, Denmark.

[4 ] Department of Oncology, Rigshospitalet, Copenhagen, Denmark; and.

[5 ] Department of Pathology, Rigshospitalet, Copenhagen, Denmark.

[6 ] Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Cophenhagen, Denmark akjaer@sund.ku.dk.

Article

Publisher Item ID: jnumed.116.174714

DOI: 10.2967/jnumed.116.174714

PubMed ID: 27469355

SO-VID: fc07a9d0-a6e7-4a23-a5eb-f415ee4f6285

History

Keywords: 18F-FDG PET,18F-FLT PET,Ki67,neuroendocrine neoplasms,prognosis

Data availability:

Keywords: 18F-FDG PET, 18F-FLT PET, Ki67, neuroendocrine neoplasms, prognosis

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