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      Disparity in Adiposity among Adults with Normal Body Mass Index and Waist-to-Height Ratio

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      1 , 1 , 1 , 2 ,
      iScience
      Elsevier
      Public Health, Nutrition, Obesity Medicine

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          Summary

          Body mass index (BMI) is commonly used to define obesity. However, concerns about its accuracy in predicting adiposity have been raised. The feasibility of using BMI as well as waist-height ratio (WHtR) in assessing adiposity was examined in relation to a more direct measurement of percent body fat (%BF). We analyzed the relation between dual-energy X-ray absorptiometry (DXA)-measured fat mass and BMI and WHtR using the US 1999–2004 National Health and Nutrition Examination Survey (NHANES) data. A considerable proportion of subjects in the healthy BMI range 20–25 were found to have excess adiposity, including 33.1% of males and 51.9% of females. The use of WHtR also supports the notion of normal-weight central obesity (NWCO), which increases with age. These findings have important implications not only for clinical practice but also for many comparative studies where control subjects are usually selected based on age, sex, and BMI.

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          Highlights

          • BMI > 30 reliably defines obesity regardless of age and sex

          • People with BMI of 20–25 and WHtR < 0.5 showed age-dependent hidden obesity

          • Subjects with excess body fat and BMI range of 20–25 showed increased WHtR with increased age

          • The present study supports the new notion of normal-weight central obesity

          Abstract

          Public Health; Nutrition; Obesity Medicine

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          Most cited references18

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          Prevalence of Obesity Among Adults and Youth: United States, 2015-2016.

          Obesity is associated with serious health risks. Monitoring obesity prevalence is relevant for public health programs that focus on reducing or preventing obesity. Between 2003–2004 and 2013–2014, there were no significant changes in childhood obesity prevalence, but adults showed an increasing trend. This report provides the most recent national estimates from 2015–2016 on obesity prevalence by sex, age, and race and Hispanic origin, and overall estimates from 1999–2000 through 2015–2016.
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            The concept of normal weight obesity.

            Individuals with normal body weight by body mass index (BMI) and high body fat percentage show a high degree of metabolic dysregulation. This phenomenon, defined as normal weight obesity, is associated with a significantly higher risk of developing metabolic syndrome, cardiometabolic dysfunction and with higher mortality. Recently, we have also shown that coronary artery disease patients with normal BMI and central obesity have the highest mortality risk as compared to other adiposity patterns. Therefore, it is important to recognize these high-risk groups for better adiposity-based risk stratification. There is a need for an updated definition of obesity based on adiposity, not on body weight. © 2014.
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              Indices of relative weight and obesity.

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                Author and article information

                Contributors
                Journal
                iScience
                iScience
                iScience
                Elsevier
                2589-0042
                31 October 2019
                22 November 2019
                31 October 2019
                : 21
                : 612-623
                Affiliations
                [1 ]Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC1027, Chicago, IL 60637, USA
                Author notes
                []Corresponding author mhara@ 123456uchicago.edu
                [2]

                Lead Contact

                Article
                S2589-0042(19)30443-2
                10.1016/j.isci.2019.10.062
                6889773
                31731199
                fc7bc332-2da0-485d-a2f4-02395a76bddd
                © 2019 The Author(s)

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 8 March 2019
                : 10 June 2019
                : 28 October 2019
                Categories
                Article

                public health,nutrition,obesity medicine
                public health, nutrition, obesity medicine

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