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      The CSMD1 genome-wide associated schizophrenia risk variant rs10503253 affects general cognitive ability and executive function in healthy males.

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          Abstract

          The single-nucleotide polymorphism (SNP) rs10503253, located within the CUB and Sushi multiple domains-1 (CSMD1) gene on 8p23.2, has reached genome-wide support as a risk factor for schizophrenia. There is initial but inconclusive evidence for a role of this variant in aspects of cognition.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Schizophr. Res.
          Title: Schizophrenia research
          ISSN (Electronic): 1573-2509
          ISSN (Print): 0920-9964
          Publication date (Electronic): Apr 2014
          Volume: 154
          Issue: 1-3
          Affiliations
          [1 ] Department of Psychiatry, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
          [2 ] Department of Psychiatry, Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Science, Institute for Multiscale Biology, Mount Sinai, New York, NY, USA; Mental Illness Research, Education, and Clinical Center (VISN 3), James J. Peters VA Medical Center, Bronx, NY, USA.
          [3 ] Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA; Feinstein Institute for Medical Research, Manhasset, NY, USA.
          [4 ] Department of Psychiatry, Mount Sinai, New York, NY, USA; Mental Illness Research, Education, and Clinical Center (VISN 3), James J. Peters VA Medical Center, Bronx, NY, USA.
          [5 ] Department of Psychology, University of Crete, Rethymno, Crete, Greece.
          [6 ] Department of Psychiatry, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece. Electronic address: pbitsios@med.uoc.gr.
          Article
          Publisher Item ID: S0920-9964(14)00083-8
          DOI: 10.1016/j.schres.2014.02.017
          PubMed ID: 24630139
          SO-VID: fdc6f0ca-cd85-43e7-93c0-0719405a75db
          Copyright © Copyright © 2014 Elsevier B.V. All rights reserved.
          History

          Keywords: CSMD1 gene,Cognition,Endophenotypes,Executive function,Schizophrenia
          Data availability:
          Keywords: CSMD1 gene, Cognition, Endophenotypes, Executive function, Schizophrenia

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