A novel method for ABO-incompatible heart transplantation.

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Abstract

Since 1996, ABO-incompatible heart transplantation has been undertaken by performing whole-body plasma exchange to remove isohemagglutinins using the cardiopulmonary bypass (CPB) circuit at the time of transplantation. This requires large volumes of donated blood and blood products, causes hemodynamic instability during the exchange transfusion, and limits practical use to small children. We sought to determine the efficacy of anti-A/B immunoadsorption within the CPB circuit on removal of isohemagglutinins in an ex vivo setting before its use clinically.

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Journal

Journal ID (iso-abbrev): J Heart Lung Transplant

Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publisher: Elsevier BV

ISSN (Electronic): 1557-3117

ISSN (Print): 1053-2498

Publication date (Electronic): April 2018

Volume: 37

Issue: 4

Affiliations

[1 ] Department of Perfusion, Great Ormond Street Hospital, London.

[2 ] Department of Perfusion, Great Ormond Street Hospital, London. Electronic address: Richard.issitt@gosh.nhs.uk.

[3 ] Department of Molecular Immunology, Institute of Cardiovascular Science, University College London, London.

[4 ] Department of Flow Cytometry, Institute of Cardiovascular Science, University College London, London.

[5 ] Department of Cardiothoracic Surgery, Great Ormond Street Hospital, London; Institute of Cardiovascular Science, University College London, London.

[6 ] Department of Transplantation, Great Ormond Street Hospital, London; Department of Paediatric Cardiology, Institute of Child Health, University College London, London, United Kingdom.

Article

Publisher Item ID: S1053-2498(17)31782-5

DOI: 10.1016/j.healun.2017.05.006

PubMed ID: 28554587

SO-VID: fe9b75a7-8da5-44ee-9663-626c40aefe21

History

Keywords: heart transplantation,paediatric,immunoadsorption,isohemagglutinin,ABO mismatch transplantation,cardiopulmonary bypass

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Keywords: heart transplantation, paediatric, immunoadsorption, isohemagglutinin, ABO mismatch transplantation, cardiopulmonary bypass

A novel method for ABO-incompatible heart transplantation.

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